Results 51 to 60 of about 90,413 (210)

Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP

Molecular & Cellular Oncology, 2018
ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis).
Dana Mamriev, Sarit Larisch
doaj   +1 more source

Blocking of Caspases Exerts Anti-Inflammatory Effects on Periodontal Cells [PDF]

, 2022
Periodontitis is an inflammatory process that is associated with caspase activity. Caspases could thus become molecular targets for the modulation of the inflammatory response to harmful factors, such as lipopolysaccharides (LPS) and TNFα.
Panahipour, Layla, Cervantes, Lara Cristina Cunha, Sordi, Mariane Beatriz, Lara Cervantes, Layla Panahipour, Mariane Beatriz Sordi, Abbasabadi, Azarakhsh Oladzad, Gruber, Reinhard, Azarakhsh Oladzad Abbasabadi, Oladzad Abbasabadi, Azarakhsh, Reinhard Gruber, Zahra Kargarpour, Cervantes, Lara Cristina Cunha [UNESP], Lara Cristina Cunha Cervantes, Kargarpour, Zahra, Mariane Sordi   +15 more
core   +1 more source

Antioxidant and Cell Proliferation Properties of the Vietnamese Traditional Medicinal Plant Peltophorum pterocarpum

Molecules, 2020
Peltophorum pterocarpum is regarded as one of the most important medicinal plants in the traditional medicine system of Vietnam. However, scientific evidence for the antioxidant effects against lipid peroxidation and the potential effects in cancer of ...
Seon-Rye Kim, Dao Cuong To, Phi Hung Nguyen, Yen Nhi Nguyen, Byung-Jun Cho, Manh Hung Tran   +5 more
doaj   +1 more source

Pyroptosis and Its Role in Autoimmune Disease: A Potential Therapeutic Target

Frontiers in Immunology, 2022
Autoimmune diseases are a group of heterogeneous diseases with diverse clinical manifestations that can be divided into systemic and organ-specific. The common etiology of autoimmune diseases is the destruction of immune tolerance and the production of ...
Ruixuan You, Ruixuan You, Xinglan He, Xinglan He, Zhuotong Zeng, Zhuotong Zeng, Yi Zhan, Yi Zhan, Yangfan Xiao, Yangfan Xiao, Rong Xiao, Rong Xiao   +11 more
doaj   +1 more source

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death [PDF]

, 2003
Caspase-directed apoptosis usually fragments cells, releasing nonfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macrophages.
Jones, David B., Simon B. Brown, Brown, Simon B, Murray C.H. Clarke, David B. Jones, Savill, John, Brendon S. Noble, Clarke, Murray C H, Noble, Brendon S, John Savill   +9 more
core   +1 more source

Metacaspases versus caspases in development and cell fate regulation [PDF]

, 2017
Initially found to be critically involved in inflammation and apoptosis, caspases have since then been implicated in the regulation of various signaling pathways in animals. How caspases and caspase-mediated processes evolved is a topic of great interest
Minina, Alyona,, Sveriges lantbruksuniversitet., Bozhkov, Peter,   +2 more
core   +3 more sources

Caspases: structural and molecular mechanisms and functions in cell death, innate immunity, and disease

Cell Discovery
Caspases are critical regulators of cell death, development, innate immunity, host defense, and disease. Upon detection of pathogens, damage-associated molecular patterns, cytokines, or other homeostatic disruptions, innate immune sensors, such as NLRs ...
Eswar Kumar Nadendla, Rebecca E. Tweedell, Gary Kasof, Thirumala-Devi Kanneganti   +3 more
doaj   +1 more source

Are metacaspases caspases? [PDF]

, 2007
The identification of caspases as major regulators of apoptotic cell death in animals initiated a quest for homologous peptidases in other kingdoms. With the discovery of metacaspases in plants, fungi, and protozoa, this search had apparently reached its
Van Breusegem, Frank, Vercammen, Dominique, Dominique Vercammen, Vandenabeele, Peter, Frank Van Breusegem, Wim Declercq, Declercq, Wim, Peter Vandenabeele   +7 more
core   +1 more source

Rubus Capped Zinc Oxide Nanoparticles Induce Apoptosis in MCF-7 Breast Cancer Cells

Molecules, 2022
Rubus fairholmianus (RF) has widely been used to treat various ailments, including pain, diabetes, and cancer. Zinc oxide nanoparticles (ZnO NPs) have drawn attention in modern healthcare applications.
Blassan P. George, Naresh K. Rajendran, Nicolette N. Houreld, Heidi Abrahamse   +3 more
doaj   +1 more source

Inactivation of Effector Caspases through Nondegradative Polyubiquitylation [PDF]

, 2008
Ubiquitin-mediated inactivation of caspases has long been postulated to contribute to the regulation of apoptosis. However, detailed mechanisms and functional consequences of caspase ubiquitylation have not been demonstrated.
Bolduc, Clare, Blagoev, Blagoy; id_orcid, Bergmann, Andreas, Blagoev, Blagoy, Meier, Pascal, Ditzel, Mark, Zvelebil, Marketa, Rigbolt, Kristoffer T G, Tenev, Tencho, Lee, Tom V, Broemer, Meike, Elliott, Richard   +11 more
core   +1 more source