Results 71 to 80 of about 90,413 (210)
Caspases in cell death, inflammation, and disease [PDF]
, 2019 Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent
Van Opdenbosch, Nina, Lamkanfi, Mohamed
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Transcriptional Regulation of Caspases in Experimental Pneumococcal Meningitis [PDF]
, 2001 Apoptosis and necrosis in brain account for neurological sequelae in survivors of bacterial meningitis. In meningitis, several mechanisms may trigger death pathways leading to activation of transcription factors regulating caspases mRNA synthesis ...
Tłustochowska, Anna +7 more
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Developmental expression patterns of zebrafish caspases. [PDF]
, 2018 Developmental expression patterns of zebrafish caspases.
Cory J. Donelson (5264564) +3 more
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Nomenclature and accession numbers of zebrafish caspases. [PDF]
, 2018 Nomenclature and accession numbers of zebrafish caspases.
Cory J. Donelson (5264564) +3 more
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Caspase Activation by Anticancer Drugs: The Caspase Storm
Molecular Pharmaceutics, 2007 This study measures the time-dependence of cellular caspase activation by anticancer drugs and compares it with that of cellular respiration. Intracellular caspase activation and cellular respiration were measured during continuous exposure of Jurkat, HL-60, and HL-60/MX2 (deficient in topoisomerase-II) cells to dactinomycin, doxorubicin, and the ...
Tao, Zhimin +3 more
openaire +2 more sources
Aspasing Out Metacaspases and Caspases: Proteases of Many Trades [PDF]
, 2010 Execution of programmed cell death (PCD) in nonmetazoan organisms is morphologically different from apoptotic PCD in animals and lacks a number of key molecular components of apoptotic machinery, including caspases. Yet protozoan, fungal, and plant cells
Boris Zhivotovsky +8 more
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Parthanatos and apoptosis: unraveling their roles in cancer cell death and therapy resistance
EXCLI Journal : Experimental and Clinical SciencesCell death is a fundamental process that needs to be maintained to balance cellular functions and prevent disease. There are several cell death pathways; however, apoptosis and parthanatos are the most prominent and have important roles in cancer biology.
Gaurav Gupta +11 more
doaj +1 more source
Obesity Science & Practice, 2023 Mechanisms underlying the negative effects of obesity on the brain are still unknown. Obesity is associated with oxidative stress in the brain and neuroinflammation that promotes neurodegenerative diseases.
Erick Gómez‐Apo +4 more
doaj +1 more source
Are membranes non-apoptotic compartments for apoptotic caspases [PDF]
, 2018 Critical mediators of apoptotic cell death are caspases, a highly specialized class of Cys-proteases that cleave substrates after Asp residues. Under normal conditions, caspases are cytosolic proteins.
Bergmann, Andreas
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mBioHerpes simplex virus-1 (HSV-1) is a neurotropic virus that can infect the brain, and an uncontrolled infection can lead to a range of diseases, including chronic nerve pain, encephalitis, and neurobehavioral abnormalities. These outcomes are often severe
Hemant Borase +3 more
doaj +1 more source