Results 81 to 90 of about 90,413 (210)
Cellular stress management by caspases [PDF]
Cellular stress plays a pivotal role in the onset of numerous human diseases. Consequently, the removal of dysfunctional cells, which undergo excessive stress-induced damage via various cell death pathways, including apoptosis, is essential for ...
Wendler, Franz +2 more
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Inflammatory caspases and inflammasomes: master switches of inflammation [PDF]
, 2007 Fifteen years have passed since the cloning and characterization of the interleukin-1beta-converting enzyme (ICE/caspase-1), the first identified member of a family of proteases currently known as caspases.
F Martinon +3 more
core +1 more source
Fonctionnalité, activation, régulation allostérique des caspases, les effecteurs de l'apoptose (création de nouveaux inhibiteurs de caspases) [PDF]
, 2003 Depuis sa découverte, l'apoptose, ou mort cellulaire programmée, a suscité un intérêt croissant de la part de la communauté scientifique internationale.
ROMETTE, Jean-Louis, CHEREAU, David
core
Frontiers in Oncology, 2019 The chemotherapeutic drug cisplatin, which targets DNA, serves as one of the main staples in cancer treatment. Yet, the therapeutic application of cisplatin is limited by two major challenges: the occurrence of reversible and irreversible side effects ...
Lihan Xie +9 more
doaj +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2010 Apoptose e seus mecanismos reguladores são eventos fisiológicos cruciais para a manutenção da homeostase placentária, e o desequilíbrio desses processos pode comprometer a função placentária e, consequentemente, o sucesso da gravidez.
K.K.O.L. Meça +3 more
doaj +1 more source
What happened to plant caspases? [PDF]
, 2008 The extent of conservation in the programmed cell death pathways that are activated in species belonging to different kingdoms is not clear. Caspases are key components of animal apoptosis; caspase activities are detected in both animal and plant cells ...
Ge, Yuan +4 more
core +1 more source
Inflammatory caspases in innate immunity and inflammation. [PDF]
, 2010 Caspases are best known for their role in apoptosis. More recently, they have gained prominence as critical mediators of innate immune responses. The so-called 'inflammatory caspases' include human caspase-1, -4, -5 and -12 and murine caspase-1, -11 and -
Drexler, S.K. +3 more
core +1 more source
Understanding Developmental Cell Death Using Drosophila as a Model System
CellsCell death plays an essential function in organismal development, wellbeing, and ageing. Many types of cell deaths have been described in the past 30 years.
Ruchi Umargamwala +4 more
doaj +1 more source
Specific targeting of human caspases using designed ankyrin repeat proteins [PDF]
, 2014 Caspases play important roles in cell death, differentiation, and proliferation. Due to their high homology, especially of the active site, specific targeting of a particular caspase using substrate analogues is very difficult.
Grütter, Markus G +5 more
core +1 more source
Non-specific effects of methyl ketone peptide inhibitors of caspases. [PDF]
, 1999 Caspases are a family of cysteine proteases which play a crucial role in apoptosis and inflammation. The involvement of caspases in these processes can be demonstrated by their irreversible inhibition with fluoromethyl ketone and chloromethyl ketone ...
Van Huffel, Sofie +9 more
core +1 more source