Results 41 to 50 of about 628,785 (360)
AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC
Nature, 2009 The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like receptor members TLR3, TLR7 and TLR8, or by the RNA helicases RIG-I (also known as DDX58) and MDA-5 (IFIH1). Little is known about
V. Hornung +7 more
semanticscholar +1 more source
Nature Communications, 2017 Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Corey Rogers +5 more
semanticscholar +1 more source
Caspase-Dependent and Caspase-Independent Pathways Are Involved in Cadmium-Induced Apoptosis in Primary Rat Proximal Tubular Cell Culture. [PDF]
, 2016 We designed this study to investigate whether cadmium induces caspase-independent apoptosis and to investigate the relationship between the caspase-dependent and caspase-independent apoptotic pathways.
Xuezhong Liu +23 more
core +1 more source
Caspase-3 content in SNU-1 cells. [PDF]
, 2021 Increase in intracellular Caspase-3 compared to blank (untreated) SNU-1 cells upon treatment with 50–5000 nm sized aminated, carboxylated and NF particles for 4 h. Data compared with respect to surface functionalization (A) or particle size (B). All data
Amrita Banerjee (382658) +2 more
core +1 more source
Frontiers in MicrobiologyPyroptosis, also known as inflammatory necrosis, is a form of programmed cell death characterized by the activation of gasdermin proteins, leading to the formation of pores in the cell membrane, continuous cell swelling, and eventual membrane rupture ...
Pan Shang +29 more
doaj +1 more source
Anti-Tumor Activity of Atractylenolide I in Human Colon Adenocarcinoma In Vitro
Molecules, 2020 Atractylodes macrocephala is known to exhibit multi-arrays of biologic activity in vitro. However, detail of its anti-tumor activity is lacking. In this study, the effects of atractylenolide I (AT-I), a bio-active compound present in Atractylodes ...
Ka Woon Karen Chan +2 more
doaj +1 more source
Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8 [PDF]
Journal of Molecular Biology, 2018 Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical ...
Sagulenko, Vitaliya +4 more
openaire +5 more sources
Caspase-4 and -5 expression in HIOs and inhibition. [PDF]
, 2022 A. Western blot measuring Caspase-4 levels in HIO lysates microinjected with PBS or STM. Blot was probed for Actin as a loading control. B. Western blot measuring Caspase-5 levels in HIO lysates that were microinjected with PBS or STM. Lysates from human
David R. Hill (2330602) +13 more
core +1 more source
Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity
eLifeTissue necrosis is a devastating complication for many human diseases and injuries. Unfortunately, our understanding of necrosis and how it impacts surrounding healthy tissue – an essential consideration when developing effective methods to treat such ...
Jacob W Klemm +2 more
doaj +1 more source
Molecules, 2016 Koumine is a kind of alkaloid extracted from Gelsemium elegans (G. elegans). Benth, which has shown promise as an anti-tumor, anxiolytic, and analgesic agent. In our present study, the effect of koumine on lipopolysaccharide (LPS)-mediated RAW 264.7 cell
Zhi-Hang Yuan +5 more
doaj +1 more source