Results 1 to 10 of about 902,846 (308)

Mitochondria and Cancer

Cell, 2016
Mitochondria are bioenergetic, biosynthetic and signaling organelles that are integral in stress sensing to allow for cellular adaptation to the environment.
Sejal Vyas, Elma Zaganjor, M. Haigis
semanticscholar   +1 more source

Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells

Molecules, 2023
Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration. Selenium nanoparticles (SeNPs) have received growing attention in various fields, but their unstable property ...
Haiyu Ji, Xiaowei Lou, Jianshuang Jiao, Yang Li, Keyao Dai, Xiaoyu Jia   +5 more
doaj   +1 more source

Repurposing mitochondria from ATP production to ROS generation drives a pro-inflammatory phenotype in macrophages that depends on succinate oxidation by complex II

Cell, 2016
Activated macrophages undergo metabolic reprogramming which drives their pro-inflammatory phenotype, but the mechanistic basis for this remains obscure.
E. Mills, B. Kelly, A. Logan, Ana S. H. Costa, M. Varma, C. Bryant, Panagiotis Tourlomousis, J. H. M. Däbritz, E. Gottlieb, I. Latorre, S. Corr, G. McManus, D. Ryan, H. Jacobs, M. Szibor, R. Xavier, T. Braun, C. Frezza, M. Murphy, L. O'Neill   +19 more
semanticscholar   +1 more source

The Multifaceted Contributions of Mitochondria to Cellular Metabolism

Nature Cell Biology, 2018
Although classically appreciated for their role as the powerhouse of the cell, the metabolic functions of mitochondria reach far beyond bioenergetics.
J. Spinelli, M. Haigis
semanticscholar   +1 more source

MSpectraAI: a powerful platform for deciphering proteome profiling of multi-tumor mass spectrometry data by using deep neural networks

BMC Bioinformatics, 2020
Background Mass spectrometry (MS) has become a promising analytical technique to acquire proteomics information for the characterization of biological samples.
Shisheng Wang, Hongwen Zhu, Hu Zhou, Jingqiu Cheng, Hao Yang   +4 more
doaj   +1 more source

Hydroxysafflor yellow A ameliorates depression-like behavior in Parkinson's disease mice

Pakistan Journal of Pharmaceutical Sciences
Depression is a common non-motor symptom of Parkinson’s disease. Previous studies demonstrated that hydroxysafflor yellow A had properties of improving motor symptoms of Parkinson’s disease.
Huilin Zhang, Xiaohan Zhang, Xue Jia, Wei Zheng, Jie He, Zhenhua Wang, Tian Wang, Bing Han   +7 more
doaj   +1 more source

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output.

Cell, 2020
Mitochondria, which play central roles in immunometabolic diseases, have their own genome. However, the functions of mitochondria-located noncoding RNAs are largely unknown due to the absence of a specific delivery system.
Qiyi Zhao, Jiayu Liu, H. Deng, Ruiying Ma, Jian-You Liao, Hui Liang, Jing-Xiong Hu, Jia-Qian Li, Zhiyong Guo, Junchao Cai, Xiaoding Xu, Zhi-Liang Gao, Shicheng Su   +12 more
semanticscholar   +1 more source

Evolution of Physical Status From Diagnosis to the End of First-Line Treatment in Breast, Lung, and Colorectal Cancer Patients: The PROTECT-01 Cohort Study Protocol

Frontiers in Oncology, 2020
Background: Cancer cachexia and exacerbated fatigue represent two hallmarks in cancer patients, negatively impacting their exercise tolerance and ultimately their quality of life.
Joris Mallard, Joris Mallard, Elyse Hucteau, Elyse Hucteau, Roland Schott, Thierry Petit, Martin Demarchi, Christine Belletier, Meher Ben Abdelghani, Hélène Carinato, Pascale Chiappa, Cathie Fischbach, Michal Kalish-Weindling, Audren Bousinière, Stéphane Dufour, Fabrice Favret, Xavier Pivot, Thomas J. Hureau, Allan F. Pagano   +18 more
doaj   +1 more source

Phosphodiesterase 4 (PDE 4) Inhibition Reduces Ischemia–Reperfusion-Induced Leucocyte Infiltration, Apoptosis and Mitochondrial Fission Markers in Mice Skeletal Muscles Four Hours After Ischemia Onset

Muscles
Peripheral arterial disease is a leading cause of amputation and/or death worldwide. Phosphodiesterase 4 (PDE 4) inhibitors demonstrated beneficial effects in ischemia–reperfusion (IR) settings, but whether PDE 4 inhibition protects skeletal muscle ...
Anne-Laure Charles, Liliane Tetsi, Giulia Quiring, Cindy Barnig, Margherita Giannini, Alain Meyer, Anne Lejay, Claire Lugnier, Bernard Geny   +8 more
doaj   +1 more source

Tafazzin Mutation Affecting Cardiolipin Leads to Increased Mitochondrial Superoxide Anions and Mitophagy Inhibition in Barth Syndrome

Cells, 2020
Tafazzin is a phospholipid transacylase that catalyzes the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation.
Patrice X. Petit, Hector Ardilla-Osorio, Lucile Penalvia, Nathan E. Rainey   +3 more
doaj   +1 more source