Results 31 to 40 of about 589,060 (317)
Protein phosphorylation in yeast mitochondria [PDF]
, 1987 We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Günter Müller +3 more
core +1 more source
Mitochondria and Neurodegeneration
Bioscience Reports, 2007 Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question “is mitochondrial dysfunction a necessary step in ...
PETROZZI, LUCIA +4 more
openaire +3 more sources
Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria [PDF]
, 1993 Nuclear-encoded proteins destined for mitochondria must cross the outer or both outer and inner membranes to reach their final sub- mitochondrial locations. While the inner membrane can translocate preproteins by itself, it is not known whether the outer
W Neupert +5 more
core +1 more source
Mitochondria Revisited. Alternative Functions of Mitochondria
Bioscience Reports, 1997 This review explores the alternative functions of mitochondria inside the cell. In a general picture of mitochondrial functioning, the importance and uniqueness of these intrinsic functions make them irreplaceable by other intracellular compartments.
D B, Zorov +4 more
openaire +2 more sources
Oncogene, 2006 Prominent features of cancer cells include metabolic imbalances and enhanced resistance to mitochondrial apoptosis. The fact that tumors rely heavily on glycolysis to meet their metabolic demands has been recognized since the beginning of the twentieth century, yet a complete elucidation of the so-called Warburg effect has not been achieved.
openaire +2 more sources
Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes
Stem Cells International, 2017 Human pluripotent stem cells derived cardiomyocytes (PSC-CMs) have been widely used for disease modeling, drug safety screening, and preclinical cell therapy to regenerate myocardium.
Dao-Fu Dai +4 more
doaj +1 more source
Preparation and Antioxidant Activities of Phenylethanoids from Dracocephalum heterophyllum
Separations, 2022 The health benefits of Dracocephalum heterophyllum are widely reported in traditional Tibetan medicines, but the reported chemical composition is limited, probably due to difficulties in separating and purifying compounds.
Yue Lv +6 more
doaj +1 more source
Targeting mitochondria by mitochondrial fusion, mitochondria-specific peptides and nanotechnology
, 2013 This thesis was focused on mitochondria as an intracellular target for drug delivery by the reason that mitochondria are becoming of increasing interest in pharmaceutical and medical research due to their contribution to several diseases (Chapter 1).
Heller, Anne Sabine
core +1 more source
Molecular Cell, 2016 Decades ago, Otto Warburg observed that cancers ferment glucose in the presence of oxygen, suggesting that defects in mitochondrial respiration may be the underlying cause of cancer. We now know that the genetic events that drive aberrant cancer cell proliferation also alter biochemical metabolism, including promoting aerobic glycolysis, but do not ...
Zong, Wei-Xing +2 more
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Mitochondria in Neurodegeneration [PDF]
, 2011 Many neurodegenerative diseases demonstrate abnormal mitochondrial morphology and biochemical dysfunction. Alterations are often systemic rather than brain-limited. Mitochondrial dysfunction may arise as a consequence of abnormal mitochondrial DNA, mutated nuclear proteins that interact directly or indirectly with mitochondria, or through unknown ...
E, Lezi, Russell H, Swerdlow
openaire +2 more sources