Antioxidants, 2023 The aim of this study is to investigate the therapeutic potential of higher doses of PU-91, quercetin, or in combination on transmitochondrial cybrid cell lines with various mtDNA haplogroups derived from patients with age-related macular degeneration ...
Nasim Salimiaghdam +8 more
doaj +1 more source
How mitochondria produce reactive oxygen species
Biochemical Journal, 2008 The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the cytosol and nucleus. Superoxide (O2•−
M. Murphy
semanticscholar +1 more source
An Overview: The Diversified Role of Mitochondria in Cancer Metabolism
International Journal on Biological Sciences, 2023 Mitochondria are intracellular organelles involved in energy production, cell metabolism and cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism and nucleic acid metabolism, but also in tumor development and ...
Yue-Ting Liu +10 more
semanticscholar +1 more source
Nucleic acids and protein synthesis in cancer cell mitochondria. I. Nucleic acids in rat hepatoma mitochondria [PDF]
, 1967 The contents of nucleic acids in rat liver and hepatoma mitochondria and the physico-chemical properties on DNA's isolated from these mitochondria were comparatively investigated. The results are briefly summarized as follows. 1.
Inaba, Kozo
core +1 more source
Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria [PDF]
, 1993 Nuclear-encoded proteins destined for mitochondria must cross the outer or both outer and inner membranes to reach their final sub- mitochondrial locations. While the inner membrane can translocate preproteins by itself, it is not known whether the outer
W Neupert +5 more
core +2 more sources
Isolation and analysis of fractions enriched in WrappER-associated mitochondria from mouse liver
STAR Protocols, 2021 Summary: The endoplasmic reticulum (ER) plays a central role in lipid homeostasis, but the role of individual ER subdomains in lipid biology has not been elucidated.
Nicolò Ilacqua +2 more
doaj +1 more source
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity
Nature Cancer, 2023 The transfer of intact mitochondria between heterogeneous cell types has been confirmed in various settings, including cancer. However, the functional implications of mitochondria transfer on tumor biology are poorly understood.
Dionysios C. Watson +41 more
semanticscholar +1 more source
Localization of TCA cycle dehydrogenases in the mitochondria [PDF]
, 1967 The site of localization of TCA cycle dehydrogenases in mitochondria has been investigated by observing the dehydrogenase activities and fine structure of the fractionated samples after freezing and thawing or sonication of beef heart and rat liver ...
Oda, Takuzo +2 more
core +1 more source
CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
Nature Communications, 2016 β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xuet al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of ...
Shangcheng Xu +8 more
doaj +1 more source
Increased susceptibility of striatal mitochondria to calcium-induced permeability transition [PDF]
, 2003 Mitochondria were simultaneously isolated from striatum and cortex of adult rats and compared in functional assays for their sensitivity to calcium activation of the permeability transition.
Brustovetsky, T +11 more
core +1 more source