Results 51 to 60 of about 902,846 (308)

FEN1-generated oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Immunity, 2022
Summary Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via cGAS-STING pathway activation and when oxidized (Ox-mtDNA), it binds cytosolic NLRP3, thereby triggering inflammasome activation. However, it is unknown how and in
Hong-Xu Xian, Kosuke Watari, E. Sanchez-Lopez, J. Offenberger, Janset Onyuru, H. Sampath, Wei Ying, H. Hoffman, G. Shadel, Michael Karin   +9 more
semanticscholar   +1 more source

Mitochondria in Health and Diseases

, 2020
Mitochondria are subcellular organelles evolved by endosymbiosis of bacteria with eukaryotic cells characteristics. They are the main source of ATP in the cell and play a pivotal role in cell life and cell death.
Andrey V. Kozlov, Amadou K. S. Camara, Sabzali Javadov   +2 more
core   +1 more source

Mitochondria and cell death-associated inflammation

Cell Death and Differentiation, 2022
Mitochondria have recently emerged as key drivers of inflammation associated with cell death. Many of the pro-inflammatory pathways activated during cell death occur upon mitochondrial outer membrane permeabilization (MOMP), the pivotal commitment point ...
Esmee Vringer, S. Tait
semanticscholar   +1 more source

Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes

Stem Cells International, 2017
Human pluripotent stem cells derived cardiomyocytes (PSC-CMs) have been widely used for disease modeling, drug safety screening, and preclinical cell therapy to regenerate myocardium.
Dao-Fu Dai, Maria Elena Danoviz, Brian Wiczer, Michael A. Laflamme, Rong Tian   +4 more
doaj   +1 more source

Preparation and Antioxidant Activities of Phenylethanoids from Dracocephalum heterophyllum

Separations, 2022
The health benefits of Dracocephalum heterophyllum are widely reported in traditional Tibetan medicines, but the reported chemical composition is limited, probably due to difficulties in separating and purifying compounds.
Yue Lv, Ze Wang, Qian Wu, Yan Fang, Qilan Wang, Gang Li, Jun Dang   +6 more
doaj   +1 more source

Lipid-droplet associated mitochondria promote fatty-acid oxidation through a distinct bioenergetic pattern in male Wistar rats

Nature Communications, 2023
Mitochondria empower the liver to regulate lipid homeostasis by enabling fatty acid oxidation during starvation and lipogenesis during nutrient-rich conditions.
Noble Kumar Talari, U. Mattam, Niroj Kumar Meher, A. Paripati, K. Mahadev, T. Krishnamoorthy, N. B. Sepuri   +6 more
semanticscholar   +1 more source

Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances

Signal Transduction and Targeted Therapy
Mitochondria are the energy production centers in cells and have unique genetic information. Due to the irreplaceable function of mitochondria, mitochondrial dysfunction often leads to pathological changes.
Xie-Yang Xu, Yan Pang, Xian-Qun Fan
semanticscholar   +1 more source

Respiratory chain complexes in dynamic mitochondria display a patchy distribution in life cells [PDF]

, 2010
Background: Mitochondria, the main suppliers of cellular energy, are dynamic organelles that fuse and divide frequently. Constraining these processes impairs mitochondrial is closely linked to certain neurodegenerative diseases.
Strecker, V., Busch, K., Winfried Haase, Wittig, I., Bereiter-Hahn, Jürgen, Haase, W., Karin Busch, Joos, Friederike, Ilka Wittig, Britta Muster, Jürgen Bereiter-Hahn, Wittig, Ilka, Wladislaw Kohl, Valentina Strecker, Busch, Karin, Haase, Winfried, Joos, F., Muster, Britta, Kohl, W., Strecker, Valentina, Friederike Joos, Muster, B., Bereiter-Hahn, J., Kohl, Wladislaw   +23 more
core   +2 more sources

Studies on ferrous ion-induced lipid peroxidation of rat liver mitochondria. I. Effect of inorganic phosphate [PDF]

, 1974
Effect of inorganic phosphate on ferrous ion- and ascorbate-induced lipid. peroxidations of isolated rat liver mitochondria was investigated. As a result it has been shown that phosphate accelerates the ferrous ion.induced lipid peroxidation; namely ...
Yamamoto, Goki, Yamamoto, Michio, Hashimoto, Gonosuke, Wakabayashi, Hiroshi, Tanabe, Masatada   +4 more
core   +1 more source

Enzymolysis-Driven Development of a Gut-Targeted Aronia melanocarpa Meal Replacement Powder with Glycemic Control and Microbial Homeostasis Benefits

Foods
In this study, the effects of enzymolysis on physicochemical properties, digestive characteristics, and flora regulation of the meal replacement powder (MRP) were investigated on the basis of the previously obtained compound MRP.
Yongxing Li, Zhihui Hu, Haiyu Ji, Shuang Yang, Ruihan Guo, Jinfang Zhang, Hongjun He, Bo Xu, Mei Li   +8 more
doaj   +1 more source