Results 41 to 50 of about 902,846 (308)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Journal of Cell Biology, 2008 Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a significant cause of early onset Parkinson's disease.
Derek P. Narendra +3 more
semanticscholar +1 more source
Glucose promotes cell growth by suppressing branched-chain amino acid degradation
Nature Communications, 2018 Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids,
Dan Shao +11 more
doaj +1 more source
An Epigenetic Role of Mitochondria in Cancer
, 2022 Mitochondria are not only the main energy supplier but are also the cell metabolic center regulating multiple key metaborates that play pivotal roles in epigenetics regulation.
Sun, Yihong +13 more
core +1 more source
Antioxidants, 2022 Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress.
Cindy Barnig +6 more
doaj +1 more source
BCL-2 family members and the mitochondria in apoptosis.
Genes & Development, 1999 A variety of physiological death signals, as well as pathological cellular insults, trigger the genetically programmed pathway of apoptosis (Vaux and Korsmeyer 1999). Apoptosis manifests in two major execution programs downstream of the death signal: the
A. Gross, J. McDonnell, S. Korsmeyer
semanticscholar +1 more source
Sarcopenia and cardiovascular diseases: A systematic review and meta‐analysis
Journal of Cachexia, Sarcopenia and Muscle, 2023 Sarcopenia is an age‐related disease and is often accompanied by other diseases. Now, many studies have shown that cardiovascular diseases (CVDs) may raise the incidence rate of sarcopenia. Therefore, the purpose of this study was to conduct a systematic
Xinrong Zuo +6 more
doaj +1 more source
Mitochondria ROS and mitophagy in acute kidney injury
Autophagy, 2022 Mitophagy is an essential mitochondrial quality control mechanism that eliminates damaged mitochondria and the production of reactive oxygen species (ROS).
L. Su +4 more
semanticscholar +1 more source
Protein phosphorylation in yeast mitochondria [PDF]
, 1987 We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Günter Müller +3 more
core +1 more source
Import of ADP/ATP carrier into mitochondria [PDF]
, 1990 We have identified the yeast homologue of Neurospora crassa MOM72, the mitochondrial import receptor for the ADP/ATP carrier (AAC), by functional studies and by cDNA sequencing.
Dietmeier, Klaus A. +8 more
core +1 more source
A new limit for blood metabolite analysis using 1H NMR spectroscopy
Journal of Magnetic Resonance Open, 2022 Human blood is the most widely used biospecimen in the clinic and the metabolomics field. While both mass spectrometry and NMR spectroscopy are the two premier analytical platforms in the metabolomics field, NMR exhibits several unsurpassed ...
G.A. Nagana Gowda +2 more
doaj +1 more source