Results 1 to 10 of about 2,113,177 (314)

Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice

Biology of Sex Differences, 2023
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metabolic dysfunction-associated steatohepatitis (MASH) with a sexual dimorphism. Fertile women exhibit lower MASLD risk than men,
Carlos Cuño-Gómiz, Estefanía de Gregorio, Anna Tutusaus, Patricia Rider, Nuria Andrés-Sánchez, Anna Colell, Albert Morales, Montserrat Marí   +7 more
doaj   +1 more source

Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore

Cell Death and Disease, 2021
The tumor suppressor prostate apoptosis response-4 (Par-4) has recently turned ‘twenty-five’. Beyond its indisputable role as an apoptosis inducer, an increasing and sometimes bewildering, new roles for Par-4 are being reported.
Anees Rahman Cheratta, Faisal Thayyullathil, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Sehamuddin Galadari   +5 more
doaj   +1 more source

Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma

Scientific Reports, 2021
In cancer cells only, TLR3 acquires death receptor properties by efficiently triggering the extrinsic pathway of apoptosis with Caspase-8 as apical protease.
Marie-Anaïs Locquet, Gabriel Ichim, Joseph Bisaccia, Aurelie Dutour, Serge Lebecque, Marie Castets, Kathrin Weber   +6 more
doaj   +1 more source

In Vitro Veritas: From 2D Cultures to Organ-on-a-Chip Models to Study Immunogenic Cell Death in the Tumor Microenvironment

Cells, 2022
Immunogenic cell death (ICD) is a functionally unique form of cell death that promotes a T-cell-dependent anti-tumor immune response specific to antigens originating from dying cancer cells.
Dmitri V. Krysko, Robin Demuynck, Iuliia Efimova, Faye Naessens, Olga Krysko, Elena Catanzaro   +5 more
doaj   +1 more source

Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y

Biology Direct, 2022
Background Rodents, such as mice, are vulnerable targets, and potential intermediate hosts, of SARS-CoV-2 variants of concern, including Alpha, Beta, Gamma, and Omicron.
Yichao Zhu, Wenzhao Zhou, Zubiao Niu, Jiayi Sun, Zhengrong Zhang, Qinqin Li, You Zheng, Chenxi Wang, Lihua Gao, Qiang Sun   +9 more
doaj   +1 more source

Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species

Antioxidants, 2021
Sorafenib and regorafenib, multikinase inhibitors (MKIs) used as standard chemotherapeutic agents for hepatocellular carcinoma (HCC), generate reactive oxygen species (ROS) during cancer treatment.
Blanca Cucarull, Anna Tutusaus, Tania Hernáez-Alsina, Pablo García de Frutos, María Reig, Anna Colell, Montserrat Marí, Albert Morales   +7 more
doaj   +1 more source

Role of Oxidative Stress in Liver Disorders

Livers, 2022
Oxygen is vital for life as it is required for many different enzymatic reactions involved in intermediate metabolism and xenobiotic biotransformation.
Laura Conde de la Rosa, Leire Goicoechea, Sandra Torres, Carmen Garcia-Ruiz, José C. Fernandez-Checa   +4 more
doaj   +1 more source

Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death

Cell Death and Disease, 2020
Radiotherapy is commonly used as a cytotoxic treatment of a wide variety of tumors. Interestingly, few case reports underlined its potential to induce immune-mediated abscopal effects, resulting in regression of metastases, distant from the irradiated ...
Sandy Adjemian, Teodora Oltean, Sofie Martens, Bartosz Wiernicki, Vera Goossens, Tom Vanden Berghe, Benjamin Cappe, Maria Ladik, Franck B. Riquet, Liesbeth Heyndrickx, Jolien Bridelance, Marnik Vuylsteke, Katrien Vandecasteele, Peter Vandenabeele   +13 more
doaj   +1 more source

PTEN-lipid Binding Assay

Bio-Protocol, 2013
The lipid and protein interactions are an integral and important part of many cellular signaling pathways. The understanding of the selective and specific interaction of the given lipid molecule with the target protein is required for studying cellular ...
Sridhar Kavela, Swapnil Shinde, Subbareddy Maddika   +2 more
doaj   +1 more source

Entosis: The emerging face of non-cell-autonomous type IV programmed death

Biomedical Journal, 2017
The present review summarizes recent experimental evidences about the existence of the non-cell-autonomous death entosis in physiological and pathophysiological contexts, discusses some aspects of this form of cell death, including morphological ...
Isabelle Martins, Syed Qasim Raza, Laurent Voisin, Haithem Dakhli, Frédéric Law, Dorine De Jong, Awatef Allouch, Maxime Thoreau, Catherine Brenner, Eric Deutsch, Jean-Luc Perfettini   +10 more
doaj   +1 more source