Results 41 to 50 of about 2,113,177 (314)
Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death [PDF]
, 2017 Death-associated protein kinase 1 (DAPK1) has been shown to have important roles in neuronal cell death in several model systems and has been implicated in multiple diseases, including Alzheimer's disease (AD).
김병모
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PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
Nature Communications, 2016 Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is ...
Swapnil Rohidas Shinde +1 more
doaj +1 more source
Autophagy and cell death [PDF]
Essays in Biochemistry, 2013 Autophagy is intimately associated with eukaryotic cell death and apoptosis. Indeed, in some cases the same proteins control both autophagy and apoptosis. Apoptotic signalling can regulate autophagy and conversely autophagy can regulate apoptosis (and most likely other cell death mechanisms).
Tohru, Yonekawa, Andrew, Thorburn
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman +7 more
wiley +1 more source
Reversal of an immunity associated plant cell death program by the growth regulator auxin
, 2007 One form of plant immunity against pathogens involves a rapid host programmed cell death at the site of infection accompanied by resistance, termed the hypersensitive response (HR).
Suresh Gopalan +2 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm +11 more
wiley +1 more source
Neuronal death mechanisms in cerebellar Purkinje cells [PDF]
, 2008 Neuropathologies often involve apoptosis and autophagy, two mechanisms of programmed cell death which require activation of specific signaling pathways.
HEITZ, Stéphane Alphonse +1 more
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Cell Death and Fibrogenesis [PDF]
Seminars in Liver Disease, 2010 Fibrosis is a common feature of chronic liver injury and is initiated by cell death inside the liver. Hepatocyte death results in apoptotic bodies and other cellular debris, which are phagocytosed by hepatic stellate cells (HSCs), resulting in their activation, proliferation, differentiation, and matrix deposition.
Wajahat, Mehal, Avlin, Imaeda
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The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death
, 2006 Histolysis refers to a widespread disintegration of tissues that is morphologically distinct from apoptosis and often associated with the stimulation of autophagy. Here, we establish that a component of the apoptosome, and pivotal regulator of apoptosis,
Xiaodong Wang +27 more
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