Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
Nature Communications, 2020 Lysosomes are intracellular organelles containing degradative enzymes, and leakage of lysosomal contents into the cell is thought to trigger cell death.
Saara Hämälistö +11 more
doaj +1 more source
RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]
, 2017 Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P. +9 more
core +1 more source
Ubiquitination in the regulation of inflammatory cell death and cancer
Cell Death and Differentiation, 2021 The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast number of cellular processes. Ubiquitination is tightly regulated at different levels by a range of enzymes including E1s, E2s, and E3s, and an array of DUBs.
Peter E Cockram +5 more
semanticscholar +1 more source
Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death [PDF]
, 2006 Histolysis refers to a widespread disintegration of tissues that is morphologically distinct from apoptosis and often associated with the stimulation of autophagy. Here, we establish that a component of the apoptosome, and pivotal regulator of apoptosis,
Abrams, John M. +11 more
core +1 more source
Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat
Oxidative Medicine and Cellular Longevity, 2021 Reactive oxygen species (ROS) are essential for cellular signaling and response to stress. The level of ROS and the type of ROS determine the ability of cells to undergo cell death.
Gloria E Villalpando-Rodriguez +1 more
semanticscholar +1 more source
PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
Nature Communications, 2016 Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is ...
Swapnil Rohidas Shinde +1 more
doaj +1 more source
The Drosophila Caspase DRONC Cleaves following Glutamate or Aspartate and Is Regulated by DIAP1, HID, and GRIM [PDF]
, 2000 The caspase family of cysteine proteases plays important roles in bringing about apoptotic cell death. All caspases studied to date cleave substrates COOH-terminal to an aspartate.
Hawkins, Christine J. +5 more
core
Caspase-independent cell death? [PDF]
Oncogene, 2002 Many cells die with apoptotic morphology and with documented activation of an effector caspase, but there are also many exceptions. Cells frequently display activation of other proteases, including granzymes, lysosomal cathepsins, matrix metalloproteinases, and proteasomal proteases, and others display morphologies that are not fully consistent with ...
Richard A, Lockshin, Zahra, Zakeri
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine +14 more
wiley +1 more source
Effector Caspase Dcp-1 and IAP Protein Bruce Regulate Starvation-Induced Autophagy during Drosophila Melanogaster Oogenesis [PDF]
, 2008 A complex relationship exists between autophagy and apoptosis, but the regulatory mechanisms underlying their interactions are largely unknown. We conducted a systematic study of Drosophila melanogaster cell death–related genes to determine their ...
Barbosa, Sharon González +4 more
core +4 more sources