Results 71 to 80 of about 2,113,177 (314)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

DCD – a novel plant specific domain in proteins involved in development and programmed cell death [PDF]

, 2005
Background: Recognition of microbial pathogens by plants triggers the hypersensitive reaction, a common form of programmed cell death in plants. These dying cells generate signals that activate the plant immune system and alarm the neighboring cells as ...
Bork Peer, Raimund Tenhaken, Tenhaken, Raimund, Tenhaken Raimund, Doerks, T., Bork, Peer, Tenhaken, R., Doerks Tobias, Bork, P., Doerks, Tobias, Peer Bork, Tobias Doerks   +11 more
core   +1 more source

Need for standardization of Influenza A virus-induced cell death in vivo to improve consistency of inter-laboratory research findings

Cell Death Discovery
The involvement of necroptosis in the control of influenza A virus (IAV) infection has been reported in multiple studies. Downstream of the nucleic acid sensor ZBP1, RIPK3 kinase activity is critically involved in the induction of necroptotic cell death ...
Teodora Oltean, Jonathan Maelfait, Xavier Saelens, Peter Vandenabeele   +3 more
doaj   +1 more source

Cell Death Signaling [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
In multicellular organisms, cell death is a critical and active process that maintains tissue homeostasis and eliminates potentially harmful cells. There are three major types of morphologically distinct cell death: apoptosis (type I cell death), autophagic cell death (type II), and necrosis (type III).
Douglas R, Green, Fabien, Llambi
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gene trapping identifies transiently induced survival genes during programmed cell death

, 2001
Background: The existence of a constitutively expressed machinery for death in individual cells has led to the notion that survival factors repress this machinery and, if such factors are unavailable, cells die by default.
Yang, Ji-Yeon, Hammann, Joanna, Wempe, Frank, Melchner, Harald von (Prof. Dr.)   +3 more
core   +1 more source

DNA methylation and differential gene regulation in photoreceptor cell death. [PDF]

, 2014
Retinitis pigmentosa (RP) defines a group of inherited degenerative retinal diseases causing progressive loss of photoreceptors. To this day, RP is still untreatable and rational treatment development will require a thorough understanding of the ...
Biel, M, Zrenner, E., Trifunovic, D, Ekström, P. A. R., Ekström, Per, Ekström, Per,, Biel, M., Zrenner, E, Farinelli, Pietro,, Paquet-Durand, Francois,, Arango-Gonzalez, B., Michalakis, S., Carell, T., Wagner, M., Paquet-Durand, F., Carell, T, Farinelli, P., Wagner, M, Michalakis, S, Perera, A, Perera, A., Trifunovic, D., Paquet-Durand, Francois, Lund University., Arango-Gonzalez, B, Farinelli, Pietro   +25 more
core   +1 more source

Role of Mitochondrial Iron Uptake in Acetaminophen Hepatotoxicity

Livers
Overdose of acetaminophen (APAP) produces fulminant hepatic necrosis. The underlying mechanism of APAP hepatotoxicity involves mitochondrial dysfunction, including mitochondrial oxidant stress and the onset of mitochondrial permeability transition (MPT).
Jiangting Hu, Anna-Liisa Nieminen, Zhi Zhong, John J. Lemasters   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Diversification of Cell Death and Immunity: Memento Mori.

, 2019
Why do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell death pathways have adapted and
Legrand, AJ, Konstantinou, M, Goode, EF, Meier, P   +3 more
core   +1 more source