Results 91 to 100 of about 8,637,589 (310)

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

Cell Reports, 2015
Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various immune receptors.
Peter Draber, Sebastian Kupka, Matthias Reichert, Helena Draberova, Elodie Lafont, Diego de Miguel, Lisanne Spilgies, Silvia Surinova, Lucia Taraborrelli, Torsten Hartwig, Eva Rieser, Luigi Martino, Katrin Rittinger, Henning Walczak   +13 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Hemotrophic mycoplasmas induce programmed cell death in red blood cells [PDF]

, 2011
Hemotrophic mycoplasmas (HM) are uncultivable bacteria found on and in the red blood cells (RBCs). The main clinical sign of HM infections is the hemolytic anemia. However, anemia-inducing pathogenesis has not been totally clarified. In this work we used
Groebel, K, Ritzmann, Mathias, Hoelzle, Katharina, Kilchling, T, Mathias Ritzmann, Ritzmann, M, Felder, Kathrin M., Hoelzle, K, Ludwig E. Hoelzle, Schiele, D, Katharina Hoelzle, Heinritzi, K, Daniela Schiele, Kilchling, Tim, Kathrin M. Felder, Tim Kilchling, Karl Heinritzi, Felder, K M, Katrin Groebel, Heinritzi, Karl, Groebel, Katrin, Schiele, Daniela, Hoelzle, Ludwig E, Hoelzle, Ludwig E.   +23 more
core   +1 more source

Harnessing ferroptosis for precision oncology: challenges and prospects

BMC Biology
The discovery of diverse molecular mechanisms of regulated cell death has opened new avenues for cancer therapy. Ferroptosis, a unique form of cell death driven by iron-catalyzed peroxidation of membrane phospholipids, holds particular promise for ...
Roberto Fernández-Acosta, Iuliana Vintea, Ine Koeken, Behrouz Hassannia, Tom Vanden Berghe   +4 more
doaj   +1 more source

Sphingomyelinases and Liver Diseases

Biomolecules, 2020
Sphingolipids (SLs) are critical components of membrane bilayers that play a crucial role in their physico-chemical properties. Ceramide is the prototype and most studied SL due to its role as a second messenger in the regulation of multiple signaling ...
Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

DCD – a novel plant specific domain in proteins involved in development and programmed cell death [PDF]

, 2005
Background: Recognition of microbial pathogens by plants triggers the hypersensitive reaction, a common form of programmed cell death in plants. These dying cells generate signals that activate the plant immune system and alarm the neighboring cells as ...
Bork Peer, Raimund Tenhaken, Tenhaken, Raimund, Tenhaken Raimund, Doerks, T., Bork, Peer, Tenhaken, R., Doerks Tobias, Bork, P., Doerks, Tobias, Peer Bork, Tobias Doerks   +11 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

DNA methylation and differential gene regulation in photoreceptor cell death. [PDF]

, 2014
Retinitis pigmentosa (RP) defines a group of inherited degenerative retinal diseases causing progressive loss of photoreceptors. To this day, RP is still untreatable and rational treatment development will require a thorough understanding of the ...
Biel, M, Zrenner, E., Trifunovic, D, Ekström, P. A. R., Ekström, Per, Ekström, Per,, Biel, M., Zrenner, E, Farinelli, Pietro,, Paquet-Durand, Francois,, Arango-Gonzalez, B., Michalakis, S., Carell, T., Wagner, M., Paquet-Durand, F., Carell, T, Farinelli, P., Wagner, M, Michalakis, S, Perera, A, Perera, A., Trifunovic, D., Paquet-Durand, Francois, Lund University., Arango-Gonzalez, B, Farinelli, Pietro   +25 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source