Results 1 to 10 of about 34,308 (261)
The double-edged functions of necroptosis
Cell Death and Disease, 2023 Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it has been implicated in the pathogenesis of many diseases, there is evidence to support that necroptosis is not purely a detrimental process. We propose that
Keng Ye, Zhimin Chen, Yanfang Xu
exaly +2 more sources
Frontiers in Genetics, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Yibo Ma +5 more
doaj +3 more sources
Targeting necroptosis in anticancer therapy: mechanisms and modulators
Acta Pharmaceutica Sinica B, 2020 Necroptosis, a genetically programmed form of necrotic cell death, serves as an important pathway in human diseases. As a critical cell-killing mechanism, necroptosis is associated with cancer progression, metastasis, and immunosurveillance.
Guoqiang Dong, Chunquan Sheng
exaly +3 more sources
Cell Death and Disease, 2021 Necroptosis is a form of regulated necrotic cell death that promotes inflammation. In cells undergoing necroptosis, activated RIPK1 kinase mediates the formation of RIPK1/RIPK3/MLKL complex to promote MLKL oligomerization and execution of necroptosis ...
Rui Zu +14 more
doaj +1 more source
p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3
Redox Biology, 2022 Mitochondrial dysfunction is a key contributor to necroptosis. We have investigated the contribution of p53, sulfiredoxin, and mitochondrial peroxiredoxin 3 to necroptosis in acute pancreatitis.
Sergio Rius-Pérez +3 more
doaj +1 more source
Potential therapeutic value of necroptosis inhibitor for the treatment of COVID-19
European Journal of Medical Research, 2022 The coronavirus disease 2019 (COVID-19), caused by a novel virus of the beta-coronavirus genus (SARS-CoV-2), has spread rapidly, posing a significant threat to global health. There are currently no drugs available for effective treatment. Severe cases of
Yongan Kang, Qinghai Wang
doaj +1 more source
Frontiers in Genetics, 2022 The latest research suggesting that necroptosis plays a vital role in immune response. However, the influence of necroptosis on tumor microenvironment (TME) remodeling and immunotherapy is still unclear. We analyzed the variations in the expression of 26
Qiwei Wang +3 more
doaj +1 more source
Necroptosis in viral infections: a twilight among progeny dissemination and host defense [PDF]
Infectious Diseases and Tropical Medicine, 2023 Decades ago, a unique cell death pathway was reported, namely ‘Necroptosis’, that exhibits both the characteristics of apoptosis, the programmed cell death mechanism, as well as the unprogrammed necrotic cell death pathway.
S. Ghosh
doaj +1 more source
Integrated stress response restricts macrophage necroptosis
Life Science Alliance, 2022 Stress inhibits necroptosis in a PERK-dependent manner via reduced RIPK1-RIPK3-MLKL signaling, showing an integral mechanistic connection between stress responses and programmed cell death.
David E Place +3 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: Necroptosis is closely related to tumorigenesis and development. Accumulating evidence has revealed that long non-coding RNAs (lncRNAs) are also central players in osteosarcoma (OS).
Binfeng Liu +9 more
doaj +1 more source