Frontiers in Cell and Developmental Biology, 2023 Background: Diabetic nephropathy (DN) was considered a severe microvascular complication of diabetes, which was recognized as the second leading cause of end-stage renal diseases.
Kaibo Hu +32 more
doaj +1 more source
PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. [PDF]
, 2018 Necroptosis, a form of regulated necrotic cell death, is governed by RIP1/RIP3-mediated activation of MLKL. However, the signaling process leading to necroptotic death remains to be elucidated.
Chen, Dongshi +7 more
core +2 more sources
Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis. [PDF]
, 2018 Understanding the molecular signaling in programmed cell death is vital to a practical understanding of inflammation and immune cell function. Here we identify a previously unrecognized mechanism that functions to downregulate the necrosome, a central ...
A Degterev +67 more
core +2 more sources
Caspase-8 controls the gut response to microbial challenges by Tnf-alpha-dependent and independent pathways [PDF]
, 2014 Objectives: Intestinal epithelial cells (IEC) express toll-like receptors (TLR) that facilitate microbial recognition. Stimulation of TLR ligands induces a transient increase in epithelial cell shedding, a mechanism that serves the antibacterial and ...
Basic, Marijana +12 more
core +3 more sources
Cell Reports, 2016 Tumor necrosis factor (TNF) induces necroptosis, a RIPK3/MLKL-dependent form of inflammatory cell death. In response to infection by Gram-negative bacteria, multiple receptors on macrophages, including TLR4, TNF, and type I IFN receptors, are ...
Diana Legarda +11 more
doaj +1 more source
HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m5C Methylation of Atf7 mRNA
Advanced Science, 2023 PIWI‐interacting RNAs (piRNAs) are highly expressed in various cardiovascular diseases. However, their role in cardiomyocyte death caused by ischemia/reperfusion (I/R) injury, especially necroptosis, remains elusive.
Kai Wang +15 more
doaj +1 more source
A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. [PDF]
, 2015 Serous Ovarian Cancers (SOC) are frequently resistant to programmed cell death. However, here we describe that these programmed death-resistant cells are nonetheless sensitive to agents that modulate autophagy.
Bartakova, Alena +10 more
core +6 more sources
Intestinal epithelial cells necroptosis and its association with intestinal inflammation [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2019 This review focuses on the role of necroptosis, an alternative mode of cell death, in the pathogenesis of diseases associated with intestinal inflammation whose prevalence has been significantly increased for last decades, which substantiates the ...
Anton S. Tkachenko
doaj +1 more source
Bibliometric analysis of publications on necroptosis from 2001 to 2021
Frontiers in Cell and Developmental Biology, 2022 Background: Necroptosis plays an important role in inflammation, cancer, and neurodegenerative diseases. In recent years, the number of studies related to necroptosis has increased and research has become increasingly in-depth.
Yang Liu +12 more
doaj +1 more source
The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis [PDF]
, 2016 Although necrosis and necroinflammation are central features of many liver diseases, the role of programmed necrosis in the context of inflammation-dependent hepatocellular death remains to be fully determined.
Andreas E. Kremer +24 more
core +1 more source