Results 41 to 50 of about 43,311 (200)
Necroptosis and Neuroinflammation in Retinal Degeneration
Frontiers in Neuroscience, 2022 Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse ...
Yan Tao +3 more
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Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections
Cell Death and Disease, 2022 Since the discovery of cell apoptosis, other gene-regulated cell deaths are gradually appreciated, including pyroptosis, ferroptosis, and necroptosis. Necroptosis is, so far, one of the best-characterized regulated necrosis.
Guangzhi Zhang +9 more
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The role of necroptosis in cancer biology and therapy
Molecular Cancer, 2019 Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem ...
Yitao Gong +10 more
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Methodology of drug screening and target identification for new necroptosis inhibitors
Journal of Pharmaceutical Analysis, 2019 Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported.
Pengchao Pan +4 more
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An Inflammatory Perspective on Necroptosis [PDF]
Molecular Cell, 2017 Necroptosis (programmed necrosis) occurs in response to TNF, Fas, or TRAIL, as well as certain TLR ligands, when caspase activity required for apoptosis is blocked. Necroptosis is typically considered a highly pro-inflammatory mode of cell death, due to release of intracellular "danger signals" that promote inflammation.
Conor J, Kearney, Seamus J, Martin
openaire +2 more sources
Frontiers in Pharmacology, 2022 Objective: Necroptosis represents a new target for cancer immunotherapy and is considered a form of cell death that overcomes apoptosis resistance and enhances tumor immunogenicity.
Kun Fang +13 more
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Neonatal obstructive nephropathy induces necroptosis and necroinflammation. [PDF]
, 2019 Urinary tract obstruction during kidney development causes tubular apoptosis, tubular necrosis, and interstitial inflammation. Necroptosis is a subtype of programmed necrosis mediated by the receptor-interacting serine/threonine-protein kinase-3 (RIPK3 ...
Keller, Ursula +6 more
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, 2022 Mixed lineage kinase domain-like pseudokinase (MLKL) is the terminal and indispensable mediator of necroptosis. Necroptosis, also known as programmed cell necrosis, is a caspase-independent cell death mechanism involved in various pathologic and ...
Chefetz, Ilana +2 more
core +1 more source
Necroptosis: is there a role for mitochondria? [PDF]
Frontiers in Physiology, 2014 Once thought to be a random process of cell death, necrosis can proceed via a defined molecular mechanism and is integral to physiological and pathological states. In particular a form of necrosis called necroptosis has been the subject of intense investigation.
Marshall, Kurt D. +1 more
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The role of RHIM in necroptosis
Biochemical Society Transactions, 2022 The RIP homotypic interaction motif (RHIM) is a conserved protein domain that is approximately 18–22 amino acids in length. In humans, four proteins carrying RHIM domains have been identified: receptor-interacting serine/threonine protein kinase (RIPK) 1, RIPK3, Z-DNA-binding protein 1 (ZBP1), and TIR domain-containing adapter-inducing IFN-β (TRIF ...
Theresa Riebeling +2 more
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