Results 41 to 50 of about 47,289 (162)
HSP70 promotes MLKL polymerization and necroptosis
, 2020 Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 ...
Zhigao Wang, Andrea N. Johnston
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TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor
Frontiers in Cell and Developmental Biology, 2020 As a programmed necrotic cell death, necroptosis has the intrinsic initiators, including receptor-interacting serine/threonine-protein kinase 1 (RIPK1), RIPK3 and mixed-lineage kinase domain-like protein (MLKL), which combine to form necroptotic ...
Lili Wang +5 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundIPF is an undetermined, progressive lung disease. Necroptosis is a type of programmed apoptosis, which involved in the pathogenesis of lung diseases like COPD and ARDS. However, necroptosis in IPF have not been adequately studied.
Hongzuo Chen +7 more
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Identification of Piperlongumine as Potent Inhibitor of Necroptosis
, 2023 Xiaoyan He,* Min Li,* Zhi Ye,* Xiaoling You, Jia Wang, Xin Xiao, Guofeng Zhu, Jun Wei, Yunhong Zha Department of Neurology, Institute of Neural Regeneration and Repair, Hubei Clinical Medical Research Center for Rare Disease of Nervous System,
He X +8 more
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, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517) +5 more
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Non-canonical role of “S6K1–SGK1” pathway in neuronal necroptosis following traumatic brain injury
Genes and DiseasesTraumatic brain injury (TBI) is characterized by high rates of death and disability. Necroptosis is reported to be involved in neuronal death after TBI. However, additional molecules and related mechanisms underlying necroptosis, particularly during TBI,
Shuchao Wang +10 more
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, 2020 Necroptosis is a regulated necrotic cell death pathway involved in development and disease. Its signaling cascade results in the formation of disulfide bond-dependent amyloid-like polymers of mixed lineage kinase domain-like protein (MLKL), which mediate
Johnston, Andrea
core +1 more source
, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517) +5 more
core +1 more source
Roles of RIPK3 in necroptosis, cell signaling, and disease [PDF]
, 2022 Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the “programmed” and “regulated” cell death pathway called necroptosis.
Morgan, Michael J. +3 more
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Tumor necrosis factor is a necroptosis-associated alarmin [PDF]
, 2022 Necroptosis is a form of regulated cell death that can occur downstream of several immune pathways. While previous studies have shown that dysregulated necroptosis can lead to strong inflammatory responses, little is known about the identity of the ...
Gaidt, Moritz M. +5 more
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