Results 51 to 60 of about 43,311 (200)
TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor
Frontiers in Cell and Developmental Biology, 2020 As a programmed necrotic cell death, necroptosis has the intrinsic initiators, including receptor-interacting serine/threonine-protein kinase 1 (RIPK1), RIPK3 and mixed-lineage kinase domain-like protein (MLKL), which combine to form necroptotic ...
Lili Wang +5 more
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Frontiers in Immunology, 2023 BackgroundIPF is an undetermined, progressive lung disease. Necroptosis is a type of programmed apoptosis, which involved in the pathogenesis of lung diseases like COPD and ARDS. However, necroptosis in IPF have not been adequately studied.
Hongzuo Chen +7 more
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Identification of Piperlongumine as Potent Inhibitor of Necroptosis
, 2023 Xiaoyan He,* Min Li,* Zhi Ye,* Xiaoling You, Jia Wang, Xin Xiao, Guofeng Zhu, Jun Wei, Yunhong Zha Department of Neurology, Institute of Neural Regeneration and Repair, Hubei Clinical Medical Research Center for Rare Disease of Nervous System,
He X +8 more
core
, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517) +5 more
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Non-canonical role of “S6K1–SGK1” pathway in neuronal necroptosis following traumatic brain injury
Genes and DiseasesTraumatic brain injury (TBI) is characterized by high rates of death and disability. Necroptosis is reported to be involved in neuronal death after TBI. However, additional molecules and related mechanisms underlying necroptosis, particularly during TBI,
Shuchao Wang +10 more
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, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517) +5 more
core +1 more source
The Function of Necroptosis and Its Treatment Target in IBD
Mediators of InflammationInflammatory bowel disease (IBD), which encompasses Crohn’s disease (CD) and ulcerative colitis (UC), is a complicated illness whose exact cause is yet unknown.
Francis Atim Akanyibah +5 more
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, 2022 Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517) +5 more
core +1 more source
Vemurafenib inhibits necroptosis in normal and pathological conditions as a RIPK1 antagonist
Cell Death and Disease, 2023 Necroptosis, a programmed cell death with necrotic-like morphology, has been recognized as an important driver in various inflammatory diseases. Inhibition of necroptosis has shown potential promise in the therapy of multiple human diseases.
Mayu Sun +10 more
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Necroptosis and Prostate Cancer: Molecular Mechanisms and Therapeutic Potential
Cells, 2022 Necroptosis is a programmed form of necrosis characterized by mitochondrial alterations and plasma membrane permeabilization resulting in the release of cytoplasmic content into extracellular space, and leading to inflammatory reactions.
Giovanni Luca Beretta, Nadia Zaffaroni
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