Results 51 to 60 of about 47,289 (162)

Necroptosis and Prostate Cancer: Molecular Mechanisms and Therapeutic Potential

Cells, 2022
Necroptosis is a programmed form of necrosis characterized by mitochondrial alterations and plasma membrane permeabilization resulting in the release of cytoplasmic content into extracellular space, and leading to inflammatory reactions.
Giovanni Luca Beretta, Nadia Zaffaroni
doaj   +1 more source

Vemurafenib inhibits necroptosis in normal and pathological conditions as a RIPK1 antagonist

Cell Death and Disease, 2023
Necroptosis, a programmed cell death with necrotic-like morphology, has been recognized as an important driver in various inflammatory diseases. Inhibition of necroptosis has shown potential promise in the therapy of multiple human diseases.
Mayu Sun, Xueqi Ma, Wei Mu, Haonan Li, Xiaoming Zhao, Tengfei Zhu, Jingquan Li, Yongliang Yang, Haibing Zhang, Qian Ba, Hui Wang   +10 more
doaj   +1 more source

Regulation of Necroptosis by Phospholipids and Sphingolipids

, 2020
Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage ...
Masaya Matsuda, Takeshi Nabe, Nobuo Yaegashi, Kazuyuki Kitatani, Xuewei Zhang   +4 more
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Necroptosis is associated with Rab27‐independent expulsion of extracellular vesicles containing RIPK3 and MLKL

Journal of Extracellular Vesicles, 2022
Extracellular vesicle (EV) secretion is an important mechanism used by cells to release biomolecules. A common necroptosis effector—mixed lineage kinase domain like (MLKL)—was recently found to participate in the biogenesis of small and large EVs ...
Kartik Gupta, Kyle A. Brown, Marvin L. Hsieh, Brandon M. Hoover, Jianxin Wang, Mitri K. Khoury, Vijaya Satish Sekhar Pilli, Reagan S. H. Beyer, Nihal R. Voruganti, Sahil Chaudhary, David S. Roberts, Regina M. Murphy, Seungpyo Hong, Ying Ge, Bo Liu   +14 more
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Proteolytic control of necroptosis [PDF]

, 2018
The present works’ aim has been to gain further insights into the proteolytic mechanisms present in necroptosis via multiple routes: investigating an in-vivo model for necroptosis in DSS-induced colitis in mice with an extremely reduced expression of the
Fuchslocher Chico, Johaiber Ilich
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Role of necroptosis and immune infiltration in essential thrombocytosis

Hereditas
Background Necroptosis, a recently identified form of programmed cell death involved in the pathogenesis of a variety of tumor and non-tumor diseases. Nevertheless, the function of necroptosis in essential thrombocytosis (ET) remains unclear, which is a ...
Guangming Li, Ying Guo, Yuanyuan Zhang
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Systematic analysis of the necroptosis index in pan-cancer and classification in discriminating the prognosis and immunotherapy responses of 1716 glioma patients

Frontiers in Pharmacology, 2023
Necroptosis is a programmed form of necrotic cell death that serves as a host gatekeeper for defense against invasion by certain pathogens. Previous studies have uncovered the essential role of necroptosis in tumor progression and implied the potential ...
Shuai Ma, Shuai Ma, Shuai Ma, Fang Wang, Qingzhen Liu, Xiaoteng Geng, Zaibin Wang, Menglei Yi, Fan Jiang, Dongtao Zhang, Junzheng Cao, Xiuwei Yan, Jiheng Zhang, Nan Wang, Heng Zhang, Lulu Peng, Zhan Liu, Shaoshan Hu, Shengzhong Tao   +18 more
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Sestrin2 maintains hepatic immune homeostasis and redox balance partially via inhibiting RIPK3-mediated necroptosis in metabolic dysfunction-associated steatohepatitis

Molecular Metabolism
Background & aims: Necroptosis, a novel type of programmed cell death, is intricately associated with inflammatory response. Currently, most studies focus on the activation of necroptosis, while the mechanisms underlying the negative regulation of ...
Jian-Bin Zhang, Qian-Ren Zhang, Qian Jin, Jing Yang, Shuang-Zhe Lin, Jian-Gao Fan   +5 more
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Osthole induces necroptosis via ROS overproduction in glioma cells

FEBS Open Bio, 2021
Glioma is a common primary malignant tumor that has a poor prognosis and often develops drug resistance. The coumarin derivative osthole has previously been reported to induce cancer cell apoptosis.
Mengjie Huangfu, Riming Wei, Juan Wang, Jianli Qin, Dan Yu, Xiao Guan, Xumei Li, Minglei Fu, Haiping Liu, Xu Chen   +9 more
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Alternative cell death pathways and cell metabolism [PDF]

, 2013
While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells.
Simone Fulda, Fulda, Simone
core   +1 more source