Results 51 to 60 of about 52,832 (305)
Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency [PDF]
, 2017 Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase activity.
Albert, Matthew L. +26 more
core +2 more sources
The role of Ubiquitination in Apoptosis and Necroptosis [PDF]
Cell Death & Differentiation, 2021 AbstractCell death pathways have evolved to maintain tissue homoeostasis and eliminate potentially harmful cells from within an organism, such as cells with damaged DNA that could lead to cancer. Apoptosis, known to eliminate cells in a predominantly non-inflammatory manner, is controlled by two main branches, the intrinsic and extrinsic apoptotic ...
Jamie Z. Roberts +2 more
openaire +4 more sources
Non-canonical role of “S6K1–SGK1” pathway in neuronal necroptosis following traumatic brain injury
Genes and DiseasesTraumatic brain injury (TBI) is characterized by high rates of death and disability. Necroptosis is reported to be involved in neuronal death after TBI. However, additional molecules and related mechanisms underlying necroptosis, particularly during TBI,
Shuchao Wang +10 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Necroptosis is a programmed form of necrotic cell death that serves as a host gatekeeper for defense against invasion by certain pathogens. Previous studies have uncovered the essential role of necroptosis in tumor progression and implied the potential ...
Shuai Ma +18 more
doaj +1 more source
The role of RHIM in necroptosis
Biochemical Society Transactions, 2022 The RIP homotypic interaction motif (RHIM) is a conserved protein domain that is approximately 18–22 amino acids in length. In humans, four proteins carrying RHIM domains have been identified: receptor-interacting serine/threonine protein kinase (RIPK) 1, RIPK3, Z-DNA-binding protein 1 (ZBP1), and TIR domain-containing adapter-inducing IFN-β (TRIF ...
Theresa Riebeling +2 more
openaire +2 more sources
Frontiers in Pharmacology, 2022 Objective: Necroptosis represents a new target for cancer immunotherapy and is considered a form of cell death that overcomes apoptosis resistance and enhances tumor immunogenicity.
Kun Fang +13 more
doaj +1 more source
Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells [PDF]
, 2019 Modern molecular medicine demands techniques to efficiently deliver molecules directly into mammalian cells. As proteins are the final mediators of most cellular pathways, efficient intracellular protein delivery techniques are highly desired.
Braeckmans, Kevin +10 more
core +2 more sources
Necroptosis: is there a role for mitochondria? [PDF]
Frontiers in Physiology, 2014 Once thought to be a random process of cell death, necrosis can proceed via a defined molecular mechanism and is integral to physiological and pathological states. In particular a form of necrosis called necroptosis has been the subject of intense investigation.
Marshall, Kurt D. +1 more
openaire +3 more sources
Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María +3 more
core +1 more source
Biomolecules, 2023 Chronic obstructive pulmonary disease (COPD) is a heterogeneous and complex progressive inflammatory disease. Necroptosis is a newly identified type of programmed cell death. However, the role of necroptosis in COPD is unclear.
Yingxi Wang +3 more
doaj +1 more source