Results 71 to 80 of about 43,311 (200)

Image2_Characterizing the prognostic and therapeutic value of necroptosis in sarcoma based on necroptosis subtypes.JPEG

, 2022
Necroptosis, a type of necrotic cell death independent of caspase regulation, is mainly mediated by receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).
Shuo Zheng (458517), Xiulin Mao (13866935), Qihang Yuan (9515160), Shiping He (9597921), Changjian Chen (12567873), Yibo Ma (573962)   +5 more
core   +1 more source

Necroptosis [PDF]

New England Journal of Medicine, 2014
Andreas, Linkermann, Douglas R, Green
openaire   +3 more sources

Sestrin2 maintains hepatic immune homeostasis and redox balance partially via inhibiting RIPK3-mediated necroptosis in metabolic dysfunction-associated steatohepatitis

Molecular Metabolism
Background & aims: Necroptosis, a novel type of programmed cell death, is intricately associated with inflammatory response. Currently, most studies focus on the activation of necroptosis, while the mechanisms underlying the negative regulation of ...
Jian-Bin Zhang, Qian-Ren Zhang, Qian Jin, Jing Yang, Shuang-Zhe Lin, Jian-Gao Fan   +5 more
doaj   +1 more source

Osthole induces necroptosis via ROS overproduction in glioma cells

FEBS Open Bio, 2021
Glioma is a common primary malignant tumor that has a poor prognosis and often develops drug resistance. The coumarin derivative osthole has previously been reported to induce cancer cell apoptosis.
Mengjie Huangfu, Riming Wei, Juan Wang, Jianli Qin, Dan Yu, Xiao Guan, Xumei Li, Minglei Fu, Haiping Liu, Xu Chen   +9 more
doaj   +1 more source

Molecular Insights into the Mechanism of Necroptosis: The Necrosome As a Potential Therapeutic Target

Cells, 2019
Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and vascularization.
Jing Chen, Renate Kos, Johan Garssen, Frank Redegeld   +3 more
doaj   +1 more source

Tumor necroptosis-mediated shedding of cell surface proteins promotes metastasis of breast cancer by suppressing anti-tumor immunity

Breast Cancer Research, 2023
Necroptosis is a form of regulated necrosis and is executed by MLKL when MLKL is engaged in triggering the rupture of cell plasma membrane. MLKL activation also leads to the protease, ADAMs-mediated ectodomain shedding of cell surface proteins of ...
Zhaoshan Liu, Swati Choksi, Hyung-Joon Kwon, Delong Jiao, Chengyu Liu, Zheng-gang Liu   +5 more
doaj   +1 more source

Programmed necrosis and necroptosis signalling [PDF]

The FEBS Journal, 2014
In recent years, the paradigm of cell death regulation has changed. Nowadays, not only apoptosis but also several forms of necrosis (e.g. necroptosis) are considered to be regulated. The central roles of receptor‐interacting serine/threonine protein kinase1 (RIPK1), RIPK3, and mixed‐lineage kinase domain‐like protein, and the molecular signalling ...
Maria, Feoktistova, Martin, Leverkus
openaire   +2 more sources

Necroptosis-related diseases are regulated by the unfolded protein response during endoplasmic reticulum stress

Genes and Diseases
In recent years, research has highlighted that necroptosis plays a significant role in various diseases, suggesting that studying the pathways of necroptosis may offer novel avenues for developing treatments for these conditions.
Tong Li, Tian Su, Sha Tang, Kun Cao, Pengbing Hua, Jingbiao Gao, Hongwang Cui, Tongmeng Jiang   +7 more
doaj   +1 more source

BID-ding on necroptosis in MDS [PDF]

Blood, 2019
In this issue of Blood, Wagner and colleagues implicate Rip1 kinase (Ripk1)–mediated necroptosis in myelodysplastic syndrome (MDS)-like disease in mice and detect increased RIPK1 expression and mixed lineage kinase domain-like pseudokinase (MLKL) activation in human MDS samples ...
Ben A. Croker, Michelle A. Kelliher
openaire   +3 more sources

Necroptosis is SARMful to your health [PDF]

Journal of Cell Biology, 2020
Necroptosis is a cell death pathway involved in inflammation and disease. In this issue, Ko et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201912047) link SARM1, the executioner of Wallerian degeneration of axons, to necroptosis, revealing a unique form of axonal disassembly likely involved in neurodegenerative disorders.
openaire   +3 more sources