The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation [PDF]
Molecular Metabolism, 2019 Objective: The mixed lineage kinase domain like (MLKL) protein, receptor interacting protein (RIPK) 1, and RIPK3 are key regulators of necroptosis, a highly pro-inflammatory mode of cell death that has been implicated in various pathological processes ...
Wenya Du, Yongmei Xie, Yuquan Wei
exaly +4 more sources
The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling [PDF]
Cell Death and Disease, 2021 MLKL phosphorylation by RIP3 is the commitment step of necroptosis execution, which could induce MLKL activation featured as MLKL monomer-oligomer transition.
Yu Zhang +7 more
doaj +3 more sources
Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging [PDF]
Nature CommunicationsHematopoietic stem cells (HSCs) survive many types of cellular stress but often lose their regenerative and lymphopoietic capacities as a result. Such functional decline also occurs with age, and dysfunctional HSCs with impaired mitochondria accumulate ...
Yuta Yamada +13 more
doaj +2 more sources
Targeting MLKL-Driven Necroptosis: A Therapeutic Target in Inflammation and Host Defense [PDF]
BiomoleculesNecroptosis is a regulated form of programmed cell death that helps the body defend itself against infections and cellular stress, especially when apoptosis is blocked. At the center of this process is mixed lineage kinase domain-like (MLKL) protein, the
Sarmistha Saha +2 more
doaj +2 more sources
MLKL in liver parenchymal cells promotes liver cancer in murine metabolic dysfunction-associated steatotic liver disease [PDF]
Cell Death and DiseaseThe rising prevalence of hepatocellular carcinoma (HCC) in the last decade is mostly attributable to the growing epidemic of metabolic dysfunction-associated steatotic liver diseases (MASLD).
Ghiles Imerzoukene +15 more
doaj +2 more sources
USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration [PDF]
Journal of Orthopaedic TranslationBackground: Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain. Programmed cell death, particularly necroptosis, contributes to nucleus pulposus (NP) cell loss.
Zhenyu Zhu +10 more
doaj +2 more sources
Necroptosis: A Novel Pathway in Neuroinflammation
Frontiers in Pharmacology, 2021 Neuroinflammation is a complex inflammatory process in the nervous system that is expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis that triggers innate immune responses by rupturing dead cells and releasing ...
Ziyu Yu +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 During development, apoptosis removes redundant cells and ensures proper organ morphogenesis. Necrosis is long known as an adult-bound inflammatory and pathologic cell death.
Han Meng +9 more
doaj +1 more source
Dynamics of necroptosis in kidney ischemia-reperfusion injury
Frontiers in Immunology, 2023 Necroptosis, a pathway of regulated necrosis, involves recruitment and activation of RIPK1, RIPK3 and MLKL, leading to cell membrane rupture, cell death and release of intracellular contents causing further injury and inflammation.
Aspasia Pefanis +13 more
doaj +1 more source
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023 Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış +3 more
doaj +1 more source