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Mechanistic analysis of MLKL-driven cell survival [PDF]
Cell Death DiscoveryMLKL pseudokinase is a critical executioner of necroptotic cell death. MLKL drives necroptosis by forming pores in the cell membrane. A growing body of data indicates that, in addition to this well-established role, MLKL can promote cell survival in ...
Peijia Jiang +3 more
doaj +2 more sources
The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation
Molecular Metabolism, 2019 Objective: The mixed lineage kinase domain like (MLKL) protein, receptor interacting protein (RIPK) 1, and RIPK3 are key regulators of necroptosis, a highly pro-inflammatory mode of cell death that has been implicated in various pathological processes ...
Xianghui Fu, Du Wenya, Yu-Quan Wei
exaly +3 more sources
Necroptosis: A Novel Pathway in Neuroinflammation
Frontiers in Pharmacology, 2021 Neuroinflammation is a complex inflammatory process in the nervous system that is expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis that triggers innate immune responses by rupturing dead cells and releasing ...
Ziyu Yu +4 more
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Frontiers in Cell and Developmental Biology, 2023 During development, apoptosis removes redundant cells and ensures proper organ morphogenesis. Necrosis is long known as an adult-bound inflammatory and pathologic cell death.
Han Meng +9 more
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Dynamics of necroptosis in kidney ischemia-reperfusion injury
Frontiers in Immunology, 2023 Necroptosis, a pathway of regulated necrosis, involves recruitment and activation of RIPK1, RIPK3 and MLKL, leading to cell membrane rupture, cell death and release of intracellular contents causing further injury and inflammation.
Aspasia Pefanis +13 more
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Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023 Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış +3 more
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Cell Death and Disease, 2021 MLKL phosphorylation by RIP3 is the commitment step of necroptosis execution, which could induce MLKL activation featured as MLKL monomer-oligomer transition.
Yu Zhang +7 more
doaj +1 more source
Necroptosis in Pulmonary Diseases: A New Therapeutic Target
Frontiers in Pharmacology, 2021 In the past decades, apoptosis has been the most well-studied regulated cell death (RCD) that has essential functions in tissue homeostasis throughout life.
Lingling Wang +6 more
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OncoImmunology, 2020 Vaccinia viruses (VACV) are a novel class of immune-oncolytic therapeutics and their mechanism of action is based both on their capacity to replicate selectively in cancer cells and to elicit danger signals that can boost anti-tumor immunity. We recently
Lien Van Hoecke +4 more
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HSP70 promotes MLKL polymerization and necroptosis
Molecular & Cellular Oncology, 2020 Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 ...
Andrea N. Johnston, Zhigao Wang
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