Results 41 to 50 of about 13,017 (220)

A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma

Cell Discovery, 2023
Mixed lineage kinase domain-like (MLKL) is widely accepted as an executioner of necroptosis, in which MLKL mediates necroptotic signaling and triggers cell death in a receptor-interacting protein kinase 3 (RIPK3)-dependent manner.
Xifei Jiang, Wenjia Deng, Siyao Tao, Zheng Tang, Yuehong Chen, Mengxin Tian, Ting Wang, Chenyang Tao, Yize Li, Yuan Fang, Congying Pu, Jun Gao, Xiaomin Wang, Weifeng Qu, Xiameng Gai, Zhenbin Ding, Yixian Fu, Ying Zheng, Siyuwei Cao, Jian Zhou, Min Huang, Weiren Liu, Jun Xu, Jia Fan, Yinghong Shi   +24 more
doaj   +1 more source

MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis

Cells, 2021
Receptor interacting protein kinase 3 (RIPK3)-mediated smooth muscle cell (SMC) necroptosis has been shown to contribute to the pathogenesis of abdominal aortic aneurysms (AAAs).
Ting Zhou, Elise DeRoo, Huan Yang, Amelia Stranz, Qiwei Wang, Roman Ginnan, Harold A. Singer, Bo Liu   +7 more
doaj   +1 more source

Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats

Journal of Neuroinflammation, 2021
Background Our previous study indicated that hypoxic preconditioning reduced receptor interacting protein (RIP) 3-mediated necroptotic neuronal death in hippocampal CA1 of adult rats after transient global cerebral ischemia (tGCI). Although mixed lineage
Lixuan Zhan, Xiaomei Lu, Wensheng Xu, Weiwen Sun, En Xu   +4 more
doaj   +1 more source

Mixed lineage kinase-like protein protects against Clostridium perfringens infection by enhancing NLRP3 inflammasome-extracellular traps axis

iScience, 2022
Summary: Despite intense research in understanding Clostridium perfringens (C. perfringens) pathogenesis, the mechanisms by which it is cleared from the host are largely unclarified. In C.
Yang Liu, Li-Hua Xing, Fen-Xin Li, Na Wang, Yu-Ze Ma, Jian-Wei Li, Yu-Jing Wu, Jing Liang, Yu-Xin Lei, Xue-Yin Wang, Fan-Hua Meng, Yong-Jun Yang, Guang-Peng Li, Xiao Wang, Shui-Xing Yu   +14 more
doaj   +1 more source

Angiotensin II triggers RIPK3-MLKL-mediated necroptosis by activating the Fas/FasL signaling pathway in renal tubular cells - Fig 5

, 2020
Disruption of RIP1, RIP3, and MLKL suppresses the necroptosis of HK-2 cells induced by Ang II (A) TUNEL-stained (green fluorescence) HK-2 cells in each treatment group were costained to detect RIP3 (red fluorescence) and the nucleus (DAPI, blue ...
Hongwang Cui (2826101), Yongjun Zhu (2794957), Liangbao Zhong (8538618), Xiaoyan Li (117291), Feng Ye (173489), Jie Lv (235936), Guojun Li (16705)   +6 more
core   +1 more source

NET formation can occur independently of RIPK3 and MLKL signaling [PDF]

, 2016
The importance of neutrophil extracellular traps (NETs) in innate immunity is well established but the molecular mechanisms responsible for their formation are still a matter of scientific dispute.
Kaufmann, Thomas, Wong, Wendy Wei-Lynn, Wicki, Simone, Yousefi, Shida, Poorya Amini, Xiaoliang Wang, Wendy Wei‐Lynn Wong, Stojkov, Darko, Hans‐Uwe Simon, Wang, Xiaoliang, Simon, Hans-Uwe, Darko Stojkov, Amini, Poorya, Shida Yousefi, Simone Wicki, Thomas Kaufmann   +15 more
core   +2 more sources

Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy

ESC Heart Failure, 2022
Aims The role of necroptosis in dilated cardiomyopathy (DCM) remains unclear. Here, we examined whether phosphorylation of mixed lineage kinase domain‐like protein (MLKL), an indispensable event for execution of necroptosis, is associated with the ...
Yugo Fujita, Toshiyuki Yano, Hiromitsu Kanamori, Daigo Nagahara, Atsuko Muranaka, Hidemichi Kouzu, Atsushi Mochizuki, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Naoyuki Kamiyama, Marenao Tanaka, Atsushi Kuno, Masaya Tanno, Tetsuji Miura   +15 more
doaj   +1 more source

The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K

Frontiers in Pharmacology, 2023
Mixed lineage kinase like protein (MLKL) is a key mediator of necroptosis. While previous studies highlighted the important role of MLKL as one of the central regulators of brain damage against acute ischemic neuronal injury, how the activation of MLKL ...
Xian-Yong Zhou, Bo Lin, Wei Chen, Rui-Qi Cao, Yi Guo, Ali Said, Taous Khan, Hui-Ling Zhang, Yong-Ming Zhu   +8 more
doaj   +1 more source

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism [PDF]

, 2013
SummaryMixed lineage kinase domain-like (MLKL) is a component of the “necrosome,” the multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell death by necroptosis. To define the specific role and molecular mechanism of MLKL action, we
Murphy, James M., Strasser, Andreas, Hatchell, Esme C., Varghese, Leila N., Alexander, Warren S., Nicola, Nicos A., Babon, Jeffrey J., Lucet, Isabelle S., Hilton, Douglas J., Hildebrand, Joanne M., Webb, Andrew I., Okamoto, Toru, Czabotar, Peter E., Tannahill, Gillian M., Metcalf, Donald, Zhang, Jian-Guo, Dobson, Renwick C.J., Young, Samuel N., Lalaoui, Najoua, Majewski, Ian J., Silke, John, Lewis, Rowena, Alvarez-Diaz, Silvia   +22 more
core   +1 more source

Structural Insights into RIP3-Mediated Necroptotic Signaling

Cell Reports, 2013
RIP3 is an essential upstream kinase in necroptosis. The pseudokinase MLKL functions as a substrate of RIP3 to mediate downstream signaling. The molecular mechanism by which RIP3 recognizes and phosphorylates MLKL remains unknown.
Tian Xie, Wei Peng, Chuangye Yan, Jianping Wu, Xinqi Gong, Yigong Shi   +5 more
doaj   +1 more source