Results 41 to 50 of about 12,009 (206)

MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis

Cells, 2021
Receptor interacting protein kinase 3 (RIPK3)-mediated smooth muscle cell (SMC) necroptosis has been shown to contribute to the pathogenesis of abdominal aortic aneurysms (AAAs).
Ting Zhou, Elise DeRoo, Huan Yang, Amelia Stranz, Qiwei Wang, Roman Ginnan, Harold A. Singer, Bo Liu   +7 more
doaj   +1 more source

MLKL variant call files- place holder [PDF]

, 2023
Variant call files for MLKL p.Ser132Pro polymorphism ...
Hildebrand, Joanne
core   +1 more source

Mixed lineage kinase-like protein protects against Clostridium perfringens infection by enhancing NLRP3 inflammasome-extracellular traps axis

iScience, 2022
Summary: Despite intense research in understanding Clostridium perfringens (C. perfringens) pathogenesis, the mechanisms by which it is cleared from the host are largely unclarified. In C.
Yang Liu, Li-Hua Xing, Fen-Xin Li, Na Wang, Yu-Ze Ma, Jian-Wei Li, Yu-Jing Wu, Jing Liang, Yu-Xin Lei, Xue-Yin Wang, Fan-Hua Meng, Yong-Jun Yang, Guang-Peng Li, Xiao Wang, Shui-Xing Yu   +14 more
doaj   +1 more source

Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy

ESC Heart Failure, 2022
Aims The role of necroptosis in dilated cardiomyopathy (DCM) remains unclear. Here, we examined whether phosphorylation of mixed lineage kinase domain‐like protein (MLKL), an indispensable event for execution of necroptosis, is associated with the ...
Yugo Fujita, Toshiyuki Yano, Hiromitsu Kanamori, Daigo Nagahara, Atsuko Muranaka, Hidemichi Kouzu, Atsushi Mochizuki, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Naoyuki Kamiyama, Marenao Tanaka, Atsushi Kuno, Masaya Tanno, Tetsuji Miura   +15 more
doaj   +1 more source

The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K

Frontiers in Pharmacology, 2023
Mixed lineage kinase like protein (MLKL) is a key mediator of necroptosis. While previous studies highlighted the important role of MLKL as one of the central regulators of brain damage against acute ischemic neuronal injury, how the activation of MLKL ...
Xian-Yong Zhou, Bo Lin, Wei Chen, Rui-Qi Cao, Yi Guo, Ali Said, Taous Khan, Hui-Ling Zhang, Yong-Ming Zhu   +8 more
doaj   +1 more source

NET formation can occur independently of RIPK3 and MLKL signaling [PDF]

, 2016
The importance of neutrophil extracellular traps (NETs) in innate immunity is well established but the molecular mechanisms responsible for their formation are still a matter of scientific dispute.
Kaufmann, Thomas, Wong, Wendy Wei-Lynn, Wicki, Simone, Yousefi, Shida, Poorya Amini, Xiaoliang Wang, Wendy Wei‐Lynn Wong, Stojkov, Darko, Hans‐Uwe Simon, Wang, Xiaoliang, Simon, Hans-Uwe, Darko Stojkov, Amini, Poorya, Shida Yousefi, Simone Wicki, Thomas Kaufmann   +15 more
core   +1 more source

The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes

iScience, 2022
Summary: Receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins are key regulators of necroptosis, a highly pro-inflammatory mode of cell death, which has been involved in various human diseases.
Julie Magusto, Carine Beaupère, Marta B. Afonso, Martine Auclair, Jean-Louis Delaunay, Pierre-Antoine Soret, Gilles Courtois, Tounsia Aït-Slimane, Chantal Housset, Isabelle Jéru, Bruno Fève, Vlad Ratziu, Cecilia M.P. Rodrigues, Jérémie Gautheron   +13 more
doaj   +1 more source

Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance [PDF]

, 2021
Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis is triggered by RIPK3-mediated phosphorylation of MLKL, which is thought to initiate MLKL ...
Tenev, T, Yu, L, Beal, AM, Liang, LY, Liccardi, G, John, SW, Fitzgibbon, C, Geddes, B, Garcia, LR, Ward, G, Fernando, W, Smyth, T, Kueh, A, Pardo, M, Young, SN, Murphy, JM, Aurelia Ball, K, Guppy, N, Bertin, J, Upton, JW, Gazinska, P, Roxanis, I, Annibaldi, A, Kim, H, Lucet, IS, Sims, M, Liang, L-Y, Newman, R, Haich, RO, Choudhary, JS, Meier, P   +30 more
core   +1 more source

A Plug Release Mechanism for Membrane Permeation by MLKL [PDF]

Structure, 2014
MLKL is crucial for necroptosis, permeabilizing membranes through its N-terminal region upon phosphorylation of its kinase-like domain by RIP3. However, the mechanism underlying membrane permeabilization is unknown. The solution structure of the MLKL N-terminal region determined by nuclear magnetic resonance spectroscopy reveals a four-helix bundle ...
Su, Lijing, Quade, Bradley, Wang, Huayi, Sun, Liming, Wang, Xiaodong, Rizo, Josep   +5 more
openaire   +2 more sources

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism [PDF]

, 2013
SummaryMixed lineage kinase domain-like (MLKL) is a component of the “necrosome,” the multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell death by necroptosis. To define the specific role and molecular mechanism of MLKL action, we
Murphy, James M., Strasser, Andreas, Hatchell, Esme C., Varghese, Leila N., Alexander, Warren S., Nicola, Nicos A., Babon, Jeffrey J., Lucet, Isabelle S., Hilton, Douglas J., Hildebrand, Joanne M., Webb, Andrew I., Okamoto, Toru, Czabotar, Peter E., Tannahill, Gillian M., Metcalf, Donald, Zhang, Jian-Guo, Dobson, Renwick C.J., Young, Samuel N., Lalaoui, Najoua, Majewski, Ian J., Silke, John, Lewis, Rowena, Alvarez-Diaz, Silvia   +22 more
core   +1 more source