Results 41 to 50 of about 11,526 (114)

Targeting MLKL-Driven Necroptosis: A Therapeutic Target in Inflammation and Host Defense

Biomolecules
Necroptosis is a regulated form of programmed cell death that helps the body defend itself against infections and cellular stress, especially when apoptosis is blocked. At the center of this process is mixed lineage kinase domain-like (MLKL) protein, the
Sarmistha Saha, Luciano Saso, Brigitta Buttari   +2 more
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MLKL is involved in the regulation of skin wound healing and interplay between macrophages and myofibroblasts in mice

Scientific Reports
Mixed lineage kinase domain-like protein (MLKL), a critical necroptosis effector, is strongly linked to inflammation, a key component of skin wound healing. However, its precise role in the wound healing process remains inadequately characterized.
Jiamin Zhao, Shuangyi Zhang, Yunjie Bai, Zhiguo Gong, Wenhui Bao, Zhuoya Yu, Bo Liu, Wei Mao, Surong Hasi   +8 more
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Inactivation of necroptosis-promoting protein MLKL creates a therapeutic vulnerability in colorectal cancer cells

Cell Death and Disease
Mortality from colorectal cancer (CRC) is significant, and novel CRC therapies are needed. A pseudokinase MLKL typically executes necroptotic cell death, and MLKL inactivation protects cells from such death.
Peijia Jiang, Sandhya Chipurupalli, Byong Hoon Yoo, Xiaoyang Liu, Kirill V. Rosen   +4 more
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USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration

Journal of Orthopaedic Translation
Background: Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain. Programmed cell death, particularly necroptosis, contributes to nucleus pulposus (NP) cell loss.
Zhenyu Zhu, Xiaofeng Lin, Fanqi Kong, Ziran Wang, Yongcheng Liang, Chenglong Ji, Hongxuan Chen, Kaiqiang Sun, Changnan Wang, Ximing Xu, Jiangang Shi   +10 more
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Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging

Nature Communications
Hematopoietic stem cells (HSCs) survive many types of cellular stress but often lose their regenerative and lymphopoietic capacities as a result. Such functional decline also occurs with age, and dysfunctional HSCs with impaired mitochondria accumulate ...
Yuta Yamada, Jinjing Yang, Akiho Saiki-Tsuchiya, Yuji Watanabe, Shuhei Koide, Shin Murai, Yuriko Sorimachi, Yu Fukuda, Kenta Sumiyama, Hiroshi Sagara, Hiroyasu Nakano, Keiyo Takubo, Atsushi Iwama, Masayuki Yamashita   +13 more
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Targeted inhibition of MLKL-mediated necroptosis attenuates chronic arsenite exposure-induced lung injury

Ecotoxicology and Environmental Safety
Arsenic, a ubiquitous environmental toxicant, poses a global public health concern through drinking water contamination. While chronic arsenic exposure is epidemiologically associated with respiratory diseases, the molecular mechanisms driving its ...
Yinan Liu, Yonghui Chen, Meng Zhang, Yawen Shi, Yixin Cui, Xinhe Zhang, Lian Li, Xu Zhao, Pinglin Yang, Jinghong Chen   +9 more
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MLKL as an emerging machinery for modulating organelle dynamics: regulatory mechanisms, pathophysiological significance, and targeted therapeutics

Frontiers in Pharmacology
Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase featured by a protein kinase-like domain without catalytic activity. MLKL was originally discovered to be phosphorylated by receptor-interacting protein kinase 1/3, typically increase ...
Yang Wang, Wei Wei, Yu Zhang, Jingrong Miao, Xiaofeng Bao, Chunfeng Lu   +5 more
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Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction

Cell Communication and Signaling
Purpose Cardiomyocyte death is a major cytopathologic response in acute myocardial infarction (AMI) and involves complex inflammatory interactions. Although existing reports indicating that mixed lineage kinase domain-like protein (MLKL) is involved in ...
Lijiang Wei, Naifu Wan, Wentong Zhu, Chenchen Liu, Zeyu Chen, Wuwei Rong, Lujun Zhang, Meifeng Xie, Yueqi Qin, Ting Sun, Qing Jing, Ankang Lyu   +11 more
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Methamphetamine Exposure Induces Neuronal Programmed Necrosis by Permeabilizing Mitochondria via the RIPK1–RIPK3–MLKL Axis

Toxics
Methamphetamine (Meth), a psychostimulant drug of the amphetamine type, is widely abused and highly neurotoxic. Meth exposure leads to neuronal necroptosis, and the mitochondrial dysfunction may be involved.
Peng Zhou, Jiankang Xuan, Weixiao Xu, Di An, Sining Meng, Hongchao Zhang, Miaoyang Hu, Wanqingyang Hui, Yifei Wang, Jie Cheng, Jianping Xiong, Jun Wang, Xufeng Chen   +12 more
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LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL

Cell Death and Disease
Plasma membrane accumulation of phosphorylated mixed lineage kinase domain-like (MLKL) is a hallmark of necroptosis, leading to membrane rupture and inflammatory cell death.
Nadine Weinelt, Kaja Nicole Wächtershäuser, Gulustan Celik, Birte Jeiler, Isabelle Gollin, Laura Zein, Sonja Smith, Geoffroy Andrieux, Tonmoy Das, Jens Roedig, Leonard Feist, Björn Rotter, Melanie Boerries, Francesco Pampaloni, Sjoerd J. L. van Wijk   +14 more
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