Results 51 to 60 of about 12,009 (206)
Necroptosis induced by RIPK3 requires MLKL but not Drp1 [PDF]
Cell Death & Disease, 2014 Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro-apoptotic Bcl-2 family members Bax or Bak. It has been reported that RIPK3 (receptor interacting protein kinase 3) activates MLKL (mixed lineage kinase domain-like) to cause cell death that requires dynamin-related protein 1 ...
Moujalled, DM +3 more
openaire +3 more sources
DataSheet2_The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K.PDF [PDF]
, 2023 Mixed lineage kinase like protein (MLKL) is a key mediator of necroptosis. While previous studies highlighted the important role of MLKL as one of the central regulators of brain damage against acute ischemic neuronal injury, how the activation of MLKL ...
Yi Guo (35817) +8 more
core +1 more source
Structural Insights into RIP3-Mediated Necroptotic Signaling
Cell Reports, 2013 RIP3 is an essential upstream kinase in necroptosis. The pseudokinase MLKL functions as a substrate of RIP3 to mediate downstream signaling. The molecular mechanism by which RIP3 recognizes and phosphorylates MLKL remains unknown.
Tian Xie +5 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2021 Burkitt's lymphoma (BL) is a highly aggressive form of B-cell non-Hodgkin's lymphoma. The clinical outcome in children with BL has improved over the last years but the prognosis for adults is still poor, highlighting the need for novel treatment ...
Annkathrin Koch +5 more
doaj +1 more source
Phosphorylated MLKL causes plasma membrane rupture [PDF]
Molecular & Cellular Oncology, 2014 Necroptosis, cell death caused by uncontrolled swelling (oncosis) and rapid plasma membrane rupture, exerts detrimental pathogenic effects.1,2 According to recent reports by Wang et al.3 in Molecul...
Linkermann, Andreas +2 more
openaire +2 more sources
MLKL regulates necrotic plasma membrane permeabilization [PDF]
Cell Research, 2014 Recent data from two independent laboratories have shed new light on the molecular mechanisms by which mixed lineage kinase domain-like (MLKL) promotes a peculiar form of regulated necrosis known as necroptosis. Upon phosphorylation by receptor-interacting protein kinase 3 (RIPK3), MLKL appears indeed to form oligomers that localize to the plasma ...
Lorenzo, Galluzzi +2 more
openaire +2 more sources
Cell Death Discovery, 2023 Mixed-lineage kinase domain-like protein (MLKL)-mediated necroptosis has been implicated in aggravating liver ischemia and reperfusion (IR) injury. However, the precise role and mechanism of MLKL in regulating oxidative DNA damage of hepatocytes and ...
Jian Xu +9 more
doaj +1 more source
NLRC4 Deficiency Leads to Enhanced Phosphorylation of MLKL and Necroptosis
ImmunoHorizons, 2022 Abstract Hosts rely on the innate immune system to clear pathogens in response to infection. Pathogen-associated molecular patterns bind to innate immune receptors and engage activation of downstream signaling to initiate a host immune response to fight infection. A key component of this innate response is programmed cell death.
Balamurugan Sundaram +2 more
openaire +2 more sources
Frontiers in Cell and Developmental BiologyIntroductionMixed Lineage Kinase Domain-Like Protein (MLKL), as the executor of necroptosis and a critical factor in the inflammation, has been shown to be associated with the progression of hemorrhagic stroke.
Yi Wang +12 more
doaj +1 more source
A novel neurodegenerative spectrum disorder in patients with MLKL deficiency [PDF]
Cell Death & Disease, 2020 Abstract Mixed lineage kinase domain-like (MLKL) is the main executor of necroptosis, an inflammatory form of programmed cell death. Necroptosis is implicated in combating infections, but also in contributing to numerous other clinical conditions, including cardiovascular diseases and neurodegenerative disorders ...
Faergeman, SL +14 more
openaire +5 more sources