Results 51 to 60 of about 13,017 (220)
Phosphorylated MLKL causes plasma membrane rupture [PDF]
Molecular & Cellular Oncology, 2014 Necroptosis, cell death caused by uncontrolled swelling (oncosis) and rapid plasma membrane rupture, exerts detrimental pathogenic effects.1,2 According to recent reports by Wang et al.3 in Molecul...
Linkermann, Andreas +2 more
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iScience, 2022 Summary: Receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins are key regulators of necroptosis, a highly pro-inflammatory mode of cell death, which has been involved in various human diseases.
Julie Magusto +13 more
doaj +1 more source
Necroptosis induced by RIPK3 requires MLKL but not Drp1 [PDF]
Cell Death & Disease, 2014 Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro-apoptotic Bcl-2 family members Bax or Bak. It has been reported that RIPK3 (receptor interacting protein kinase 3) activates MLKL (mixed lineage kinase domain-like) to cause cell death that requires dynamin-related protein 1 ...
Moujalled, DM +3 more
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Mechanistic Studies of MLKL Mediated Cell Death [PDF]
, 2020 © 2020 Katherine Anne DaviesNecroptosis is a form of inflammatory programmed cell death. Thought to have evolved to combat pathogen infection, necroptosis can be triggered via signalling through pattern recognition receptors or cytokines from the TNF ...
Davies, Katherine Anne
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Neoplasia: An International Journal for Oncology Research, 2021 Burkitt's lymphoma (BL) is a highly aggressive form of B-cell non-Hodgkin's lymphoma. The clinical outcome in children with BL has improved over the last years but the prognosis for adults is still poor, highlighting the need for novel treatment ...
Annkathrin Koch +5 more
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A Plug Release Mechanism for Membrane Permeation by MLKL [PDF]
Structure, 2014 MLKL is crucial for necroptosis, permeabilizing membranes through its N-terminal region upon phosphorylation of its kinase-like domain by RIP3. However, the mechanism underlying membrane permeabilization is unknown. The solution structure of the MLKL N-terminal region determined by nuclear magnetic resonance spectroscopy reveals a four-helix bundle ...
Su, Lijing +5 more
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MLKL regulates necrotic plasma membrane permeabilization [PDF]
Cell Research, 2014 Recent data from two independent laboratories have shed new light on the molecular mechanisms by which mixed lineage kinase domain-like (MLKL) promotes a peculiar form of regulated necrosis known as necroptosis. Upon phosphorylation by receptor-interacting protein kinase 3 (RIPK3), MLKL appears indeed to form oligomers that localize to the plasma ...
Lorenzo, Galluzzi +2 more
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Frontiers in Cell and Developmental BiologyIntroductionMixed Lineage Kinase Domain-Like Protein (MLKL), as the executor of necroptosis and a critical factor in the inflammation, has been shown to be associated with the progression of hemorrhagic stroke.
Yi Wang +12 more
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Cell Death Discovery, 2023 Mixed-lineage kinase domain-like protein (MLKL)-mediated necroptosis has been implicated in aggravating liver ischemia and reperfusion (IR) injury. However, the precise role and mechanism of MLKL in regulating oxidative DNA damage of hepatocytes and ...
Jian Xu +9 more
doaj +1 more source
, 2020 Our earlier studies proved that RIPK3-mediated necroptosis might be an important mode of renal tubular cell death in rats with chronic renal injury and the necroptotic cell death can be triggered by tumor necrosis factor-α (TNF-α) in vitro, but the ...
Hongwang Cui (2826101) +13 more
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