Results 61 to 70 of about 14,072 (183)
Profiling a killer: MLKL-mediated death and its role in human disease
, 2022 © 2022 Sarah Elizabeth GarnishNecroptosis is a lytic and caspase-independent form of programmed cell death. Highly inflammatory in nature, necroptosis results in the permeabilization of biological membranes and the release of inflammatory cytokines ...
Garnish, Sarah Elizabeth
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MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome. [PDF]
, 2016 MLKL, a key component downstream of RIPK3, is suggested to be a terminal executor of necroptosis. Genetic studies have revealed that Ripk3 ablation rescues embryonic lethality in Fadd- or Caspase-8-deficient mice.
Zhang, Haiwei +10 more
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Neoplasia: An International Journal for Oncology Research, 2021 Burkitt's lymphoma (BL) is a highly aggressive form of B-cell non-Hodgkin's lymphoma. The clinical outcome in children with BL has improved over the last years but the prognosis for adults is still poor, highlighting the need for novel treatment ...
Annkathrin Koch +5 more
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Phosphorylated MLKL causes plasma membrane rupture [PDF]
Molecular & Cellular Oncology, 2014 Necroptosis, cell death caused by uncontrolled swelling (oncosis) and rapid plasma membrane rupture, exerts detrimental pathogenic effects.1,2 According to recent reports by Wang et al.3 in Molecul...
Linkermann, Andreas +2 more
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Frontiers in Cell and Developmental BiologyIntroductionMixed Lineage Kinase Domain-Like Protein (MLKL), as the executor of necroptosis and a critical factor in the inflammation, has been shown to be associated with the progression of hemorrhagic stroke.
Yi Wang +12 more
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MLKL regulates necrotic plasma membrane permeabilization [PDF]
Cell Research, 2014 Recent data from two independent laboratories have shed new light on the molecular mechanisms by which mixed lineage kinase domain-like (MLKL) promotes a peculiar form of regulated necrosis known as necroptosis. Upon phosphorylation by receptor-interacting protein kinase 3 (RIPK3), MLKL appears indeed to form oligomers that localize to the plasma ...
Lorenzo, Galluzzi +2 more
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The composition and formation of MLKL complex in necroptosis [PDF]
, 2015 MLKL的多聚化对于TNF介导的RIP3依赖的细胞坏死非常关键，但是MLKL多聚化的分子机制还不清楚。我们研究发现，MLKL形成的多聚体包含八个MLKL分子，由两个二硫键偶联的四聚体以头对头的形式组成。在四聚体中鼠源MLKL的第169位和275位的半胱氨酸形成分子间的二硫键，但是细胞坏死并不依赖于分子间的二硫键。自磷酸化的RIP3募集MLKL到坏死小体中，在坏死小体中MLKL被RIP3磷酸化，磷酸化的MLKL在坏死小体中形成多聚体 ...
黄德力
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MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates [PDF]
, 2014 Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood.
Sylvie Montessuit +47 more
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NLRC4 Deficiency Leads to Enhanced Phosphorylation of MLKL and Necroptosis
ImmunoHorizons, 2022 Abstract Hosts rely on the innate immune system to clear pathogens in response to infection. Pathogen-associated molecular patterns bind to innate immune receptors and engage activation of downstream signaling to initiate a host immune response to fight infection. A key component of this innate response is programmed cell death.
Balamurugan Sundaram +2 more
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Cell Death Discovery, 2023 Mixed-lineage kinase domain-like protein (MLKL)-mediated necroptosis has been implicated in aggravating liver ischemia and reperfusion (IR) injury. However, the precise role and mechanism of MLKL in regulating oxidative DNA damage of hepatocytes and ...
Jian Xu +9 more
doaj +1 more source