Results 81 to 90 of about 14,072 (183)

MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF [PDF]

, 2022
The blockade of cellular differentiation represents a hallmark of acute myeloid leukemia (AML), which is largely attributed to the dysfunction of lineage-specific transcription factors controlling cellular differentiation. However, alternative mechanisms
Belka, C., Dill, V., Herold, T., Jost, P., Ros, U. ; https://orcid.org/, Agrawal, D., Garcia Saez, A. ; https://orcid.org/, Bassermann, F., Wang, X., Shen, B., Mishra, R., Keller, E., Slotta-Huspenina, J., Shi, R.   +13 more
core   +1 more source

MLKL ubiquitylation: more than a makeover [PDF]

Cell Death & Differentiation, 2022
Weihong Wang, Yi-Nan Gong
openaire   +2 more sources

Investigation of MLKL ubiquitylation during necroptosis

, 2019
© 2019 Zikou LiuNecroptosis is one type of caspase 8-independent programmed cell death. Mixed lineage kinase domain-like (MLKL) is the essential terminal effector in the necroptosis signalling pathway.
Liu, Zikou
core   +1 more source

Leveraging ZBP1 signaling for cancer immunotherapy

Frontiers in Cell Death
Immune checkpoint inhibitors (ICIs) have transformed cancer care, yet durable responses remain limited in a majority of patients. This is particularly true of immunologically cold tumors, which are characterized by insufficient T-cell infiltration, low ...
Parth Desai, Chunxia Wen, Siddharth Balachandran   +2 more
doaj   +1 more source

Increased MLKL mRNA level in the PBMCs is correlated with autoantibody production, renal involvement, and SLE disease activity

Arthritis Research & Therapy, 2020
Background Necroptosis is a form of regulated necrosis that is involved in various autoimmune diseases. Mixed lineage kinase domain-like pseudokinase (MLKL) has been identified as a key executor of necroptosis; however, the significance of MLKL in ...
Mingjiao Zhang, Hongyu Jie, Yong Wu, Xinai Han, Xing Li, Yi He, Xingliang Shi, Yuwei Luo, Ying Sun, Jinlong Yang, Jing Yang, Shulv Quan, Xiaobin Lao, Liping Tan, Erwei Sun   +14 more
doaj   +1 more source

Angiotensin II triggers RIPK3-MLKL-mediated necroptosis by activating the Fas/FasL signaling pathway in renal tubular cells

, 2020
Our earlier studies proved that RIPK3-mediated necroptosis might be an important mode of renal tubular cell death in rats with chronic renal injury and the necroptotic cell death can be triggered by tumor necrosis factor-α (TNF-α) in vitro, but the ...
Hongwang Cui (2826101), Yongjun Zhu (2794957), Liangbao Zhong, Guojun Li, Xiaoyan Li (117291), Guojun Li (16705), Yongjun Zhu, Xiaoyan Li, Hongwang Cui, Liangbao Zhong (8538618), Jie Lv, Feng Ye (173489), Jie Lv (235936), Feng Ye   +13 more
core   +1 more source

MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction

Molecular Brain, 2023
Necroptosis is known to play an important role in the pathophysiology of cerebral ischemia; however, its role in the occurrence of secondary thalamic injury after focal cerebral infarction and the mechanism about how mixed lineage kinase domain-like ...
Yanyan Tang, Quanhong Chu, Guanfeng Xie, Yafu Tan, Ziming Ye, Chao Qin   +5 more
doaj   +1 more source

MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF.

, 2021
The blockade of cellular differentiation represents a hallmark of acute myeloid leukemia (AML), which is largely attributed to the dysfunction of lineage-specific transcription factors controlling cellular differentiation. However, alternative mechanisms
Belka, C., Dill, V., Herold, T., Jost, P.J., Misra, R., Agrawal, D., García-Sáez, A.J., Ros, U., Bassermann, F., Wang, X., Keller, E.C., Shen, B., Slotta-Huspenina, J., Shi, R., Eva C. Keller, Deepti Agrawal, Xin Wang, Run Shi, Florian Bassermann, Bo Shen, Philipp J. Jost, Uris Ros, Ana J. Garcia-Saez, Julia Slotta-Huspenina, Tobias Herold, Wang, Xin ; Ros, Uris ; Agrawal, Deepti ; Keller, Eva C. ; Slotta-Huspenina, Julia ; Dill, Veronika ; Shen, Bo ; Shi, Run ; Herold, Tobias ; Belka, Claus ; Mishra, Ritu ; Bassermann, Florian ; Garcia-Saez, Ana J. ; Jost, Philipp J., Claus Belka, Veronika Dill, Ritu Mishra   +28 more
core   +1 more source

Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation

Frontiers in Immunology, 2018
The intestinal mucosal barrier is critical for host defense against pathogens infection. Here, we demonstrate that the mixed lineage kinase-like protein (MLKL), a necroptosis effector, promotes intestinal epithelial barrier function by enhancing ...
Shui-Xing Yu, Wei Chen, Zhen-Zhen Liu, Feng-Hua Zhou, Shi-Qing Yan, Gui-Qiu Hu, Xiao-Xia Qin, Jie Zhang, Ke Ma, Chong-Tao Du, Jing-Min Gu, Xu-Ming Deng, Wen-Yu Han, Yong-Jun Yang   +13 more
doaj   +1 more source

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

, 2020
MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, Mlkl, that alters the two-helix ‘brace’ that connects the killer four-helix bundle and regulatory ...
Josefsson, Emma C., Hall, Cathrine, Tanzer, Maria C., Cox, Allison J., Anderton, Holly, Pellegrini, Marc, Di Rago, Ladina, Garnish, Sarah E., Gangatirkar, Pradnya, Petrie, Emma J., Czabotar, Peter E., Varghese, Leila, Rickard, James A., Allison, Cody C., Miyake, Sanae, Young, Samuel N., Majewski, Ian J., Corbin, Jason, Tripaydonis, Anne, Li, Zhixiu, Brumatti, Gabriela, Kauppi, Maria, Silk, Michael A., Hildebrand, Joanne M., Liu, Zikou, Sheridan, Julie, Jackson, Victoria E., Zhang, Jian-Guo, Rigbye, Kristin, Scerri, Thomas S., Stutz, Michael D.   +30 more
core   +1 more source