Results 1 to 10 of about 17,865 (198)

RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation [PDF]

Cell, 2017
Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Brian P Daniels, Annelise G Snyder, Susana Orozco   +2 more
exaly   +5 more sources

RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis

Frontiers in Oncology, 2021
Receptor-interacting protein 3 (RIPK3), a member of the family of serine/threonine protein kinases, emerged as a critical regulator of necroptosis. Downregulated expression of RIPK3 is correlated with poor prognosis in multiple tumor types. Here, we show
Qun Zhao, Jian Guo, Xinran Cheng, Yingying Liao, Yun Bi, Yingxia Gong, Xudong Zhang, Yang Guo, Xianhui Wang, Wei Yu, Shu Jin, Yan Tan, Xianjun Yu   +12 more
doaj   +2 more sources

A viable kinase-inactive RIPK3 D143N mouse model reveals its scaffold function in driving TNF-induced inflammatory disorder [PDF]

Cell Death Discovery
RIPK3 is a key regulator of necroptosis, but the specific roles of its kinase-dependent and -independent functions in disease pathogenesis remain poorly understood.
Yayun Du, Jingjing Li, Cong Zhao, Shouqiao Hou, Qiuye Li, Xiangping Xu, Zhanhui Li, Jiaying Qiu, Changyu Zhuang, Lifen Xie, Feng Ma, Xiaohu Zhang, Xiaoliang Yu, Sudan He   +13 more
doaj   +2 more sources

RIPK3 Promotes JEV Replication in Neurons via Downregulation of IFI44L

Frontiers in Microbiology, 2020
Japanese encephalitis virus (JEV), the leading cause of viral encephalitis in Asia, is neurovirulent and neuroinvasive. Neurons are the main target of JEV infection and propagation.
Peiyu Bian, Xuyang Zheng, Yuan Wang
exaly   +3 more sources

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis [PDF]

, 2014
In human cells, the RIPK1-RIPK3-MLKL-PGAM5-Drp1 axis drives tumor necrosis factor (TNF)-induced necroptosis through mitochondrial fission, but whether this pathway is conserved among mammals is not known. To answer this question, we analyzed the presence
Baekelandt, V, Bertrand, Mathieu, Bruggeman, Inge, Dondelinger, Yves, Gonçalves, Amanda, Goossens, Vera, Grootjans, Sasker, Remijsen, Quinten, Roelandt, Ria, Takahashi, Nozomi, Van den Haute, C, Vanden Berghe, Tom, Vandenabeele, Peter, Vanlangenakker, Nele   +13 more
core   +5 more sources

Autophagy-Related LC3 Accumulation Interacted Directly With LIR Containing RIPK1 and RIPK3, Stimulating Necroptosis in Hypoxic Cardiomyocytes [PDF]

Frontiers in Cell and Developmental Biology, 2021
The exact relationships and detailed mechanisms between autophagy and necroptosis remain obscure. Here, we demonstrated the link between accumulated autophagosome and necroptosis by intervening with autophagic flux.
Yao Huang, Yanhai Feng, Lin Cui, Lei Yang, Qiong Zhang, Junhui Zhang, Xupin Jiang, Xingyue Zhang, Yanling Lv, Jie-Zhi Jia, Dong-Xia Zhang, Yue-Sheng Huang, Yue-Sheng Huang   +12 more
doaj   +2 more sources

Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

eLife
Receptor interacting protein kinases (RIPK) RIPK1 and RIPK3 play important roles in diverse innate immune pathways. Despite this, some RIPK1/3-associated proteins are absent in specific vertebrate lineages, suggesting that some RIPK1/3 functions are ...
Elizabeth J Fay, Kolya Isterabadi, Charles M Rezanka, Jessica Le, Matthew D Daugherty   +4 more
doaj   +3 more sources

Bilirubin directly activates RIPK3 to induce non-classical necroptosis [PDF]

Cell Discovery
Bilirubin, a byproduct of heme metabolism, is traditionally recognized for its antioxidant properties. However, its accumulation under pathological conditions can result in severe clinical manifestations, including neurotoxicity.
Qian Xue, Xi Ma, Ziyuan Chen, Feifei Ge, Jiawen Wu, Wenhao Bao, Li Zhou, Wei Yi, Min Wu, Siyan Liao, Wenwen Xu, Rongrong He, Jingcheng Feng, Yameng Hu, Xi Chen, Xintian Wu, Ding Yan, Daolin Tang, Xin Chen, Jinbao Liu   +19 more
doaj   +2 more sources

Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury

Redox Biology, 2017
Ripk3-required necroptosis and mitochondria-mediated apoptosis are the predominant types of cell death that largely account for the development of cardiac ischemia reperfusion injury (IRI). Here, we explored the effect of Ripk3 on mitochondrial apoptosis.
Hao Zhou, Pingjun Zhu, Jun Guo
exaly   +3 more sources

RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis [PDF]

Advanced Science
Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant tissue remodeling and immune dysregulation. While receptor‐interacting protein kinase 3 (RIPK3) is canonically recognized as a central executioner of necroptosis, its non‐necroptotic ...
Tao Yang, Xiao Li, Shuyue Lei, Qingqing Li, Yi Zhang, Zhizhen Hui, Jinjin Ren, Xuelian Yang, Xiaoqian Yang, Chunlan Feng, Yousheng Xu, Dongxin Zhao, Wei Tang   +12 more
doaj   +2 more sources