Results 1 to 10 of about 11,849 (130)

PolyProline Predictor: A web server for empirical sequence-based prediction of polyproline II helices. [PDF]

Protein Sci
Abstract Polyproline II (PPII) helices are extended left‐handed secondary structures increasingly recognized for their roles in molecular recognition, signaling and within intrinsically disordered regions of proteins. Despite their functional importance, predicting regions with propensity to form PPII helices from sequence alone remains challenging due
López-Sánchez R, Pantoja-Uceda D, Mompeán M, Laurents DV.   +3 more
europepmc   +2 more sources

RIPK3 Promotes JEV Replication in Neurons via Downregulation of IFI44L

Frontiers in Microbiology, 2020
Japanese encephalitis virus (JEV), the leading cause of viral encephalitis in Asia, is neurovirulent and neuroinvasive. Neurons are the main target of JEV infection and propagation.
Zhansheng Jia, Yuan Wang, Xuyang Zheng   +2 more
exaly   +3 more sources

A viable kinase-inactive RIPK3 D143N mouse model reveals its scaffold function in driving TNF-induced inflammatory disorder [PDF]

Cell Death Discovery
RIPK3 is a key regulator of necroptosis, but the specific roles of its kinase-dependent and -independent functions in disease pathogenesis remain poorly understood.
Yayun Du, Jingjing Li, Cong Zhao, Shouqiao Hou, Qiuye Li, Xiangping Xu, Zhanhui Li, Jiaying Qiu, Changyu Zhuang, Lifen Xie, Feng Ma, Xiaohu Zhang, Xiaoliang Yu, Sudan He   +13 more
doaj   +2 more sources

ORF3 protein of porcine circovirus type 2 induced RIPK3 phosphorylation-driven autophagy to promote viral replication [PDF]

Scientific Reports
Receptor-interacting protein kinase-3 (RIPK3), a critical regulator of necroptosis and inflammation, has been implicated in modulating viral infections by either promoting host defense or facilitating viral replication.
Zijing Guo, Jingsong Chen, Yuling Li, Yongqiang Lin, Xiongting Huang, Yu Chen, Yanmin Li, Zhidong Zhang   +7 more
doaj   +2 more sources

Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury

Redox Biology, 2017
Ripk3-required necroptosis and mitochondria-mediated apoptosis are the predominant types of cell death that largely account for the development of cardiac ischemia reperfusion injury (IRI). Here, we explored the effect of Ripk3 on mitochondrial apoptosis.
Hao Zhou, , Pingjun Zhu
exaly   +3 more sources

Bilirubin directly activates RIPK3 to induce non-classical necroptosis [PDF]

Cell Discovery
Bilirubin, a byproduct of heme metabolism, is traditionally recognized for its antioxidant properties. However, its accumulation under pathological conditions can result in severe clinical manifestations, including neurotoxicity.
Qian Xue, Xi Ma, Ziyuan Chen, Feifei Ge, Jiawen Wu, Wenhao Bao, Li Zhou, Wei Yi, Min Wu, Siyan Liao, Wenwen Xu, Rongrong He, Jingcheng Feng, Yameng Hu, Xi Chen, Xintian Wu, Ding Yan, Daolin Tang, Xin Chen, Jinbao Liu   +19 more
doaj   +2 more sources

RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis [PDF]

Advanced Science
Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant tissue remodeling and immune dysregulation. While receptor‐interacting protein kinase 3 (RIPK3) is canonically recognized as a central executioner of necroptosis, its non‐necroptotic ...
Tao Yang, Xiao Li, Shuyue Lei, Qingqing Li, Yi Zhang, Zhizhen Hui, Jinjin Ren, Xuelian Yang, Xiaoqian Yang, Chunlan Feng, Yousheng Xu, Dongxin Zhao, Wei Tang   +12 more
doaj   +2 more sources

Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: A novel mechanism linking Ripk3-modified mitochondrial performance and endoplasmic reticulum function

Redox Biology, 2019
The basic pathophysiological mechanisms underlying septic cardiomyopathy have not yet been completely clarified. Disease-specific treatments are lacking, and care is still based on supportive modalities.
Zhigang Guo, Hong Tian, Jichen Liu
exaly   +3 more sources

Structure-Based Virtual Screening of Cinnamic Acid Analogs Against RIPK3: Implications for Anti-Inflammatory Drug Discovery [PDF]

Avicenna Journal of Medical Biochemistry, 2023
Background: A common oral inflammatory disease known as apical periodontitis (AP) is caused by the intrusion of microorganisms into the dental pulp, resulting in an inflammatory response and bone degradation in periapical tissues.
Elham Khoshbin, Seyed Mohamad Soroosh Rahmani-Abidar, Shadi Moradi , Amir Taherkhani , Hamed Karkehabadi   +4 more
doaj   +1 more source

Low-Dose Resveratrol Inhibits RIPK3-Mediated Necroptosis and Delays the Onset of Age-Related Hearing Loss

Frontiers in Pharmacology, 2022
Background: To investigate the pathophysiology of age-related hearing loss (ARHL) and the mechanism of resveratrol (RSV) in prevention and treatment of ARHL.Methods: C57BL/6 mice of different ages were used in this study. Auditory brainstem response (ABR)
Zeyin Yang, Zeyin Yang, Yan Zhang, Shuling Yang, Yongqing Ding, Yan Qu   +5 more
doaj   +1 more source