Results 1 to 10 of about 808 (102)

Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury

Redox Biology, 2017
Ripk3-required necroptosis and mitochondria-mediated apoptosis are the predominant types of cell death that largely account for the development of cardiac ischemia reperfusion injury (IRI). Here, we explored the effect of Ripk3 on mitochondrial apoptosis.
Hao Zhou, Pingjun Zhu
exaly   +3 more sources

Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: A novel mechanism linking Ripk3-modified mitochondrial performance and endoplasmic reticulum function

Redox Biology, 2019
The basic pathophysiological mechanisms underlying septic cardiomyopathy have not yet been completely clarified. Disease-specific treatments are lacking, and care is still based on supportive modalities.
Zhigang Guo, Hong Tian, Jichen Liu
exaly   +3 more sources

Structure-Based Virtual Screening of Cinnamic Acid Analogs Against RIPK3: Implications for Anti-Inflammatory Drug Discovery [PDF]

Avicenna Journal of Medical Biochemistry, 2023
Background: A common oral inflammatory disease known as apical periodontitis (AP) is caused by the intrusion of microorganisms into the dental pulp, resulting in an inflammatory response and bone degradation in periapical tissues.
Elham Khoshbin, Seyed Mohamad Soroosh Rahmani-Abidar, Shadi Moradi , Amir Taherkhani , Hamed Karkehabadi   +4 more
doaj   +1 more source

Low-Dose Resveratrol Inhibits RIPK3-Mediated Necroptosis and Delays the Onset of Age-Related Hearing Loss

Frontiers in Pharmacology, 2022
Background: To investigate the pathophysiology of age-related hearing loss (ARHL) and the mechanism of resveratrol (RSV) in prevention and treatment of ARHL.Methods: C57BL/6 mice of different ages were used in this study. Auditory brainstem response (ABR)
Zeyin Yang, Zeyin Yang, Yan Zhang, Shuling Yang, Yongqing Ding, Yan Qu   +5 more
doaj   +1 more source

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

iScience, 2022
Summary: Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated necroptosis and caspase-8-dependent apoptosis. However, the post-translational control of RIPK3
Daniel Frank, Sarah E. Garnish, Jarrod J. Sandow, Ashley Weir, Lin Liu, Elise Clayer, Lizeth Meza, Maryam Rashidi, Simon A. Cobbold, Simon R. Scutts, Marcel Doerflinger, Holly Anderton, Kate E. Lawlor, Najoua Lalaoui, Andrew J. Kueh, Vik Ven Eng, Rebecca L. Ambrose, Marco J. Herold, Andre L. Samson, Rebecca Feltham, James M. Murphy, Gregor Ebert, Jaclyn S. Pearson, James E. Vince   +23 more
doaj   +1 more source

Quercetin'in HT-29 ve HCT-116 kolon kanseri hücre hatları üzerine etkisinin RIPK1, RIPK3 ve MLKL genlerinin ekspresyonları ile incelenmesi

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023
Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış, Esra Bozgeyik, Alp Can Tuncer, Sevval Has   +3 more
doaj   +1 more source

Necroptosis: A Novel Pathway in Neuroinflammation

Frontiers in Pharmacology, 2021
Neuroinflammation is a complex inflammatory process in the nervous system that is expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis that triggers innate immune responses by rupturing dead cells and releasing ...
Ziyu Yu, Nan Jiang, Nan Jiang, Wenru Su, Yehong Zhuo   +4 more
doaj   +1 more source

Comparative and evolutionary analysis of RIP kinases in immune responses

Frontiers in Genetics, 2022
The group of receptor-interacting protein (RIP) kinases has seven members (RIPK1–7), with one homologous kinase domain but distinct non-kinase regions.
Shangge Lv, Yu Jiang, Yuzheng Li, Ruilin Huang, Lingyu Peng, Zhaoyin Ma, Nan Lu, Xiaoying Lin, Jie Yan   +8 more
doaj   +1 more source

RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis

Frontiers in Oncology, 2021
Receptor-interacting protein 3 (RIPK3), a member of the family of serine/threonine protein kinases, emerged as a critical regulator of necroptosis. Downregulated expression of RIPK3 is correlated with poor prognosis in multiple tumor types. Here, we show
Qun Zhao, Jian Guo, Xinran Cheng, Yingying Liao, Yun Bi, Yingxia Gong, Xudong Zhang, Yang Guo, Xianhui Wang, Wei Yu, Shu Jin, Yan Tan, Xianjun Yu   +12 more
doaj   +1 more source

A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression

eLife, 2021
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) normally signals to necroptosis by phosphorylating MLKL. We report here that when the cellular RIPK3 chaperone Hsp90/CDC37 level is low, RIPK3 also signals to apoptosis.
Dianrong Li, Jie Chen, Jia Guo, Lin Li, Gaihong Cai, She Chen, Jia Huang, Hui Yang, Yinhua Zhuang, Fengchao Wang, Xiaodong Wang   +10 more
doaj   +1 more source