Results 41 to 50 of about 2,978 (173)
Border Security: The Role of RIPK3 in Epithelium Homeostasis [PDF]
Frontiers in Cell and Developmental Biology, 2016 Receptor interacting protein kinase 3 (RIPK3) is a crucial inducer of necroptosis. Its activity is controlled by interaction with other signal adaptors through the "RIP homotypic interaction motif" (RHIM). Recent studies revealed a critical function for RIPK3 in the maintenance of epithelial tissue integrity.
Moriwaki, Kenta +2 more
openaire +3 more sources
Viruses, 2022 Receptor interacting protein kinase 3 (RIPK3) is a vital serine/threonine kinase in regulating the programmed destruction of infected cells to defend against RNA viruses.
Guanming Tian +12 more
doaj +1 more source
RIPK3 Contributes to Lyso-Gb3-Induced Podocyte Death [PDF]
Cells, 2021 Fabry disease is a lysosomal storage disease with an X-linked heritage caused by absent or decreased activity of lysosomal enzymes named alpha-galactosidase A (α-gal A). Among the various manifestations of Fabry disease, Fabry nephropathy significantly affects patients’ morbidity and mortality.
So-Young Kim +10 more
openaire +3 more sources
Cytoplasmic MYC is an anti-necroptotic protein
Molecular & Cellular Oncology, 2020 Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a ...
Eun-Woo Lee +2 more
doaj +1 more source
The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis. [PDF]
, 2021 RIPK3 amyloid complex plays crucial roles during TNF-induced necroptosis and in response to immune defense in both human and mouse. Here, we have structurally characterized mouse RIPK3 homogeneous self-assembly using solid-state NMR, revealing a well ...
Zhang, Jing +11 more
core +1 more source
Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome [PDF]
Journal of Biological Chemistry, 2016 Receptor-interacting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential function in necroptosis. The activity of RIPK3 is controlled by phosphorylation. Once activated, RIPK3 phosphorylates and activates the downstream effector mixed lineage kinase domain-like (MLKL) to induce necroptosis.
Kenta, Moriwaki, Francis Ka-Ming, Chan
openaire +2 more sources
PLoS ONE, 2021 The receptor-interacting protein kinase 3 (RIPK3) is a multi-functional protein best known for facilitating cellular necroptosis and inflammation. Recent evidence from our lab indicates that RIPK3 expression must be tightly regulated in endothelial cells
Siqi Gao +3 more
doaj +1 more source
RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α. [PDF]
, 2020 Cytokine-primed neutrophils can undergo a nonapoptotic type of cell death using components of the necroptotic pathway, including receptor-interacting protein kinase-3 (RIPK3), mixed lineage kinase-like (MLKL) and NADPH oxidase. In this report, we provide
Perozzo, Remo +10 more
core +1 more source
RIPK3 in necroptosis and cancer
Molecules and CellsReceptor-interacting protein kinase-3 is essential for the cell death pathway called necroptosis. Necroptosis is activated by the death receptor ligands and pattern recognition receptors of the innate immune system, leading to significant consequences in inflammation and in diseases, particularly cancer.
Michael J. Morgan, You-Sun Kim
openaire +2 more sources
Roles of RIPK3 in necroptosis, cell signaling, and disease
Experimental & Molecular Medicine, 2022 AbstractReceptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the “programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is activated by the death receptor ligands and pattern recognition receptors of the innate immune system, and the findings of many reports have suggested that necroptosis is highly
Michael J. Morgan, You-Sun Kim
openaire +2 more sources