Results 41 to 50 of about 15,294 (209)
The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis. [PDF]
, 2021 RIPK3 amyloid complex plays crucial roles during TNF-induced necroptosis and in response to immune defense in both human and mouse. Here, we have structurally characterized mouse RIPK3 homogeneous self-assembly using solid-state NMR, revealing a well ...
Zhang, Jing +11 more
core +1 more source
Border Security: The Role of RIPK3 in Epithelium Homeostasis [PDF]
Frontiers in Cell and Developmental Biology, 2016 Receptor interacting protein kinase 3 (RIPK3) is a crucial inducer of necroptosis. Its activity is controlled by interaction with other signal adaptors through the "RIP homotypic interaction motif" (RHIM). Recent studies revealed a critical function for RIPK3 in the maintenance of epithelial tissue integrity.
Moriwaki, Kenta +2 more
openaire +3 more sources
RIPK3 Contributes to Lyso-Gb3-Induced Podocyte Death [PDF]
Cells, 2021 Fabry disease is a lysosomal storage disease with an X-linked heritage caused by absent or decreased activity of lysosomal enzymes named alpha-galactosidase A (α-gal A). Among the various manifestations of Fabry disease, Fabry nephropathy significantly affects patients’ morbidity and mortality.
So-Young Kim +10 more
openaire +3 more sources
Cytoplasmic MYC is an anti-necroptotic protein
Molecular & Cellular Oncology, 2020 Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a ...
Eun-Woo Lee +2 more
doaj +1 more source
Viruses, 2022 Receptor interacting protein kinase 3 (RIPK3) is a vital serine/threonine kinase in regulating the programmed destruction of infected cells to defend against RNA viruses.
Guanming Tian +12 more
doaj +1 more source
, 2021 Restoration of RIPK3 expression triggers necroptosis in RIPK3-negative MM cells. A, Lentivirus expressing RIPK3-WT, RIPK3-KD, or empty vector only was used to transduce RIPK3-negative MM cells at MOI=5.
Eleonora Sementino (14916552) +14 more
core +1 more source
Necroptosis induced by RIPK3 requires MLKL but not Drp1 [PDF]
Cell Death & Disease, 2014 Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro-apoptotic Bcl-2 family members Bax or Bak. It has been reported that RIPK3 (receptor interacting protein kinase 3) activates MLKL (mixed lineage kinase domain-like) to cause cell death that requires dynamin-related protein 1 ...
Moujalled, DM +3 more
openaire +3 more sources
Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome [PDF]
Journal of Biological Chemistry, 2016 Receptor-interacting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential function in necroptosis. The activity of RIPK3 is controlled by phosphorylation. Once activated, RIPK3 phosphorylates and activates the downstream effector mixed lineage kinase domain-like (MLKL) to induce necroptosis.
Kenta, Moriwaki, Francis Ka-Ming, Chan
openaire +2 more sources
, 2021 Treatment of MM cells with the DNA demethylase 5-aza-2'-deoxycytidine (5-Aza) results in restoration of RIPK3 expression. MM cells lacking RIPK3 protein expression (RIPK3-negative) were treated with 30 µM of 5-Aza for 4 days.
Eleonora Sementino (14916552) +14 more
core +1 more source
RIPK3 in necroptosis and cancer
Molecules and CellsReceptor-interacting protein kinase-3 is essential for the cell death pathway called necroptosis. Necroptosis is activated by the death receptor ligands and pattern recognition receptors of the innate immune system, leading to significant consequences in inflammation and in diseases, particularly cancer.
Michael J. Morgan, You-Sun Kim
openaire +2 more sources