Results 21 to 30 of about 17,938 (260)

Necroptosis in Pulmonary Diseases: A New Therapeutic Target

Frontiers in Pharmacology, 2021
In the past decades, apoptosis has been the most well-studied regulated cell death (RCD) that has essential functions in tissue homeostasis throughout life.
Lingling Wang, Ling Zhou, Yuhao Zhou, Lu Liu, Weiling Jiang, Huojun Zhang, Huiguo Liu   +6 more
doaj   +1 more source

Cpd-42 protects against calcium oxalate nephrocalcinosis-induced renal injury and inflammation by targeting RIPK3-mediated necroptosis

Frontiers in Pharmacology, 2022
Calcium oxalate (CaOx) crystals, as the predominant component of human kidney stones, can trigger excessive cell death and inflammation of renal tubular epithelial cells, involved in the pathogenesis of nephrocalcinosis.
Bingbing Hou, Bingbing Hou, Bingbing Hou, Mingming Liu, Yang Chen, Yang Chen, Yang Chen, Weijian Ni, Xiaoguo Suo, Yuexian Xu, Yuexian Xu, Yuexian Xu, Qiushi He, Qiushi He, Qiushi He, Xiaoming Meng, Zongyao Hao, Zongyao Hao, Zongyao Hao   +18 more
doaj   +1 more source

RIPK3: Beyond Necroptosis [PDF]

Immunity, 2019
In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV control.
Evans, Azia S, Coyne, Carolyn B
openaire   +2 more sources

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Quercetin'in HT-29 ve HCT-116 kolon kanseri hücre hatları üzerine etkisinin RIPK1, RIPK3 ve MLKL genlerinin ekspresyonları ile incelenmesi

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023
Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış, Esra Bozgeyik, Alp Can Tuncer, Sevval Has   +3 more
doaj   +1 more source

RIPK3: A New Player in Renal Fibrosis [PDF]

Frontiers in Cell and Developmental Biology, 2020
Chronic kidney disease (CKD) is the end result of a plethora of renal insults, including repeated episodes of acute or toxic kidney injury, glomerular, or diabetic kidney disease. It affects a large number of the population worldwide, resulting in significant personal morbidity and mortality and economic cost to the community.
Ying Shi, Xinming Chen, Chunling Huang, Carol Pollock   +3 more
openaire   +3 more sources

Necroptosis: A Novel Pathway in Neuroinflammation

Frontiers in Pharmacology, 2021
Neuroinflammation is a complex inflammatory process in the nervous system that is expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis that triggers innate immune responses by rupturing dead cells and releasing ...
Ziyu Yu, Nan Jiang, Nan Jiang, Wenru Su, Yehong Zhuo   +4 more
doaj   +1 more source

Execution of RIPK3-regulated necrosis [PDF]

Molecular & Cellular Oncology, 2014
Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptors are able to trigger necroptosis.
Cai, Zhenyu, Liu, Zheng-Gang
openaire   +2 more sources

Comparative and evolutionary analysis of RIP kinases in immune responses

Frontiers in Genetics, 2022
The group of receptor-interacting protein (RIP) kinases has seven members (RIPK1–7), with one homologous kinase domain but distinct non-kinase regions.
Shangge Lv, Yu Jiang, Yuzheng Li, Ruilin Huang, Lingyu Peng, Zhaoyin Ma, Nan Lu, Xiaoying Lin, Jie Yan   +8 more
doaj   +1 more source

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources