Results 21 to 30 of about 2,978 (173)
Cell Reports, 2017 Receptor interacting protein kinase 3 (RIPK3) induces necroptosis, a type of regulated necrosis, through its kinase domain and receptor interacting protein (RIP) homotypic interaction motif (RHIM).
Kenta Moriwaki +4 more
doaj +2 more sources
GADD45β inhibits RIPK3-mediated NF-κB activation by interfering with NEMO-RIPK1-RIPK3 interactions
Cell Death DiscoveryNecroptosis is a highly inflammatory form of regulated cell death driven by Receptor-Interacting Protein Kinase 3 (RIPK3), which plays a crucial role in immune responses, inflammatory diseases, and tumor microenvironment modulation.
Carmela Casale +10 more
doaj +6 more sources
RIPK3 Contributes to Thyroid Hormone-Induced Photoreceptor Degeneration
International Journal of Molecular SciencesThyroid hormone (TH) regulates cell proliferation, differentiation, and metabolism. Increased TH levels in circulation are associated with a higher incidence of age-related macular degeneration.
Yun Le +4 more
core +3 more sources
c-Abl activates RIPK3 signaling in Gaucher disease [PDF]
, 2021 Gaucher disease (GD) is caused by homozygous mutations in the GBA1 gene, which encodes the lysosomal β-glucosidase (GBA) enzyme. GD affects several organs and tissues, including the brain in certain variants of the disease. Heterozygous GBA1 variants are
Marín, T. +6 more
core +3 more sources
Primary cilia suppress Ripk3-mediated necroptosis [PDF]
Cell Death Discovery, 2022 AbstractCilia are sensory organelles that project from the surface of almost all cells. Nephronophthisis (NPH) and NPH-related ciliopathies are degenerative genetic diseases caused by mutation of cilia-associated genes. These kidney disorders are characterized by progressive loss of functional tubular epithelial cells which is associated with ...
Emilia Kieckhöfer +7 more
openaire +3 more sources
RIPK3: A New Player in Renal Fibrosis [PDF]
Frontiers in Cell and Developmental Biology, 2020 Chronic kidney disease (CKD) is the end result of a plethora of renal insults, including repeated episodes of acute or toxic kidney injury, glomerular, or diabetic kidney disease. It affects a large number of the population worldwide, resulting in significant personal morbidity and mortality and economic cost to the community.
Ying Shi +3 more
openaire +3 more sources
Execution of RIPK3-regulated necrosis [PDF]
Molecular & Cellular Oncology, 2014 Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptors are able to trigger necroptosis.
Cai, Zhenyu, Liu, Zheng-Gang
openaire +2 more sources
The Role of RIPK1 and RIPK3 in Cardiovascular Disease [PDF]
International Journal of Molecular Sciences, 2020 Cardiovascular diseases, including peripheral arterial and venous disease, myocardial infarction, and stroke, are the number one cause of death worldwide annually. In the last 20 years, the role of necroptosis, a newly identified form of regulated necrotic cell death, in cardiovascular disease has come to light.
Elise DeRoo, Ting Zhou, Bo Liu
openaire +2 more sources
Necroptosis in Pulmonary Diseases: A New Therapeutic Target
Frontiers in Pharmacology, 2021 In the past decades, apoptosis has been the most well-studied regulated cell death (RCD) that has essential functions in tissue homeostasis throughout life.
Lingling Wang +6 more
doaj +1 more source
Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury
International Journal of Hyperthermia, 2020 Background Worldwide heat stroke incidence has increased in recent years and is associated with high morbidity and mortality. Therefore, it is critical to identify mechanisms that mediate heat stroke.
Li Li +9 more
doaj +1 more source