Results 21 to 30 of about 11,899 (172)
RIPK3: A New Player in Renal Fibrosis [PDF]
Frontiers in Cell and Developmental Biology, 2020 Chronic kidney disease (CKD) is the end result of a plethora of renal insults, including repeated episodes of acute or toxic kidney injury, glomerular, or diabetic kidney disease. It affects a large number of the population worldwide, resulting in significant personal morbidity and mortality and economic cost to the community.
Ying Shi +3 more
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Execution of RIPK3-regulated necrosis [PDF]
Molecular & Cellular Oncology, 2014 Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptors are able to trigger necroptosis.
Cai, Zhenyu, Liu, Zheng-Gang
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eLife, 2021 Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) normally signals to necroptosis by phosphorylating MLKL. We report here that when the cellular RIPK3 chaperone Hsp90/CDC37 level is low, RIPK3 also signals to apoptosis.
Dianrong Li +10 more
doaj +1 more source
Primary cilia suppress Ripk3-mediated necroptosis [PDF]
Cell Death Discovery, 2022 AbstractCilia are sensory organelles that project from the surface of almost all cells. Nephronophthisis (NPH) and NPH-related ciliopathies are degenerative genetic diseases caused by mutation of cilia-associated genes. These kidney disorders are characterized by progressive loss of functional tubular epithelial cells which is associated with ...
Emilia Kieckhöfer +7 more
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The Role of RIPK1 and RIPK3 in Cardiovascular Disease [PDF]
International Journal of Molecular Sciences, 2020 Cardiovascular diseases, including peripheral arterial and venous disease, myocardial infarction, and stroke, are the number one cause of death worldwide annually. In the last 20 years, the role of necroptosis, a newly identified form of regulated necrotic cell death, in cardiovascular disease has come to light.
Elise DeRoo, Ting Zhou, Bo Liu
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Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury
International Journal of Hyperthermia, 2020 Background Worldwide heat stroke incidence has increased in recent years and is associated with high morbidity and mortality. Therefore, it is critical to identify mechanisms that mediate heat stroke.
Li Li +9 more
doaj +1 more source
Killing AML: RIPK3 leads the way [PDF]
Cell Cycle, 2016 Acute myeloid leukemia (AML) is a heterogeneous group of haematopoietic neoplasms driven partly by the loss of differentiation and the blockade of cell death.
Ulrike, Höckendorf +2 more
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Necroptosis in Pulmonary Diseases: A New Therapeutic Target
Frontiers in Pharmacology, 2021 In the past decades, apoptosis has been the most well-studied regulated cell death (RCD) that has essential functions in tissue homeostasis throughout life.
Lingling Wang +6 more
doaj +1 more source
Cell Death Discovery, 2022 Neutrophils are important effector cells during inflammation, which play complex roles. Therefore, investigating the regulation of neutrophil accumulation during inflammation might provide targets for treating related diseases.
Wanying Wen +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Calcium oxalate (CaOx) crystals, as the predominant component of human kidney stones, can trigger excessive cell death and inflammation of renal tubular epithelial cells, involved in the pathogenesis of nephrocalcinosis.
Bingbing Hou +18 more
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