Results 21 to 30 of about 15,294 (209)
GADD45β inhibits RIPK3-mediated NF-κB activation by interfering with NEMO-RIPK1-RIPK3 interactions
Cell Death DiscoveryNecroptosis is a highly inflammatory form of regulated cell death driven by Receptor-Interacting Protein Kinase 3 (RIPK3), which plays a crucial role in immune responses, inflammatory diseases, and tumor microenvironment modulation.
Carmela Casale +10 more
doaj +6 more sources
RIPK3/Fas-Associated Death Domain Axis Regulates Pulmonary Immunopathology to Cryptococcal Infection Independent of Necroptosis [PDF]
Frontiers in Immunology, 2017 Fas-associated death domain (FADD) and receptor interacting protein kinase 3 (RIPK3) are multifunctional regulators of cell death and immune response. Using a mouse model of cryptococcal infection, the roles of FADD and RIPK3 in anti-cryptococcal defense
Zhenzong Fa +17 more
doaj +2 more sources
RIPK3: Beyond Necroptosis [PDF]
Immunity, 2019 In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV control.
Evans, Azia S, Coyne, Carolyn B
openaire +2 more sources
eLife, 2021 Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) normally signals to necroptosis by phosphorylating MLKL. We report here that when the cellular RIPK3 chaperone Hsp90/CDC37 level is low, RIPK3 also signals to apoptosis.
Dianrong Li +10 more
doaj +1 more source
Primary cilia suppress Ripk3-mediated necroptosis [PDF]
Cell Death Discovery, 2022 AbstractCilia are sensory organelles that project from the surface of almost all cells. Nephronophthisis (NPH) and NPH-related ciliopathies are degenerative genetic diseases caused by mutation of cilia-associated genes. These kidney disorders are characterized by progressive loss of functional tubular epithelial cells which is associated with ...
Emilia Kieckhöfer +7 more
openaire +3 more sources
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023 Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış +3 more
doaj +1 more source
RIPK3: A New Player in Renal Fibrosis [PDF]
Frontiers in Cell and Developmental Biology, 2020 Chronic kidney disease (CKD) is the end result of a plethora of renal insults, including repeated episodes of acute or toxic kidney injury, glomerular, or diabetic kidney disease. It affects a large number of the population worldwide, resulting in significant personal morbidity and mortality and economic cost to the community.
Ying Shi +3 more
openaire +3 more sources
Execution of RIPK3-regulated necrosis [PDF]
Molecular & Cellular Oncology, 2014 Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptors are able to trigger necroptosis.
Cai, Zhenyu, Liu, Zheng-Gang
openaire +2 more sources
The Role of RIPK1 and RIPK3 in Cardiovascular Disease [PDF]
International Journal of Molecular Sciences, 2020 Cardiovascular diseases, including peripheral arterial and venous disease, myocardial infarction, and stroke, are the number one cause of death worldwide annually. In the last 20 years, the role of necroptosis, a newly identified form of regulated necrotic cell death, in cardiovascular disease has come to light.
Elise DeRoo, Ting Zhou, Bo Liu
openaire +2 more sources
Necroptosis in Pulmonary Diseases: A New Therapeutic Target
Frontiers in Pharmacology, 2021 In the past decades, apoptosis has been the most well-studied regulated cell death (RCD) that has essential functions in tissue homeostasis throughout life.
Lingling Wang +6 more
doaj +1 more source