Results 11 to 20 of about 11,899 (172)
Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death
iScience, 2022 Summary: Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated necroptosis and caspase-8-dependent apoptosis. However, the post-translational control of RIPK3
Daniel Frank +23 more
doaj +8 more sources
RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis [PDF]
Frontiers in Oncology, 2021 Receptor-interacting protein 3 (RIPK3), a member of the family of serine/threonine protein kinases, emerged as a critical regulator of necroptosis. Downregulated expression of RIPK3 is correlated with poor prognosis in multiple tumor types. Here, we show
Qun Zhao +12 more
doaj +3 more sources
Nefrología (English Edition)Receptor interacting protein kinase 3 (RIPK3) is an intracellular kinase at the crossroads of cell death and inflammation. RIPK3 contains a RIP homotypic interaction motif (RHIM) domain which allows interactions with other RHIM-containing proteins and a ...
Juan Guerrero-Mauvecin +4 more
doaj +8 more sources
PRMT5-mediated regulatory arginine methylation of RIPK3
Cell Death Discovery, 2023 The TNF receptor-interacting protein kinases (RIPK)-1 and 3 are regulators of extrinsic cell death response pathways, where RIPK1 makes the cell survival or death decisions by associating with distinct complexes mediating survival signaling, caspase ...
Chanchal Chauhan +7 more
doaj +5 more sources
GADD45β inhibits RIPK3-mediated NF-κB activation by interfering with NEMO-RIPK1-RIPK3 interactions
Cell Death DiscoveryNecroptosis is a highly inflammatory form of regulated cell death driven by Receptor-Interacting Protein Kinase 3 (RIPK3), which plays a crucial role in immune responses, inflammatory diseases, and tumor microenvironment modulation.
Carmela Casale +10 more
doaj +6 more sources
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023 Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış +3 more
doaj +1 more source
Necroptosis: A Novel Pathway in Neuroinflammation
Frontiers in Pharmacology, 2021 Neuroinflammation is a complex inflammatory process in the nervous system that is expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis that triggers innate immune responses by rupturing dead cells and releasing ...
Ziyu Yu +4 more
doaj +1 more source
RIPK3: Beyond Necroptosis [PDF]
Immunity, 2019 In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV control.
Evans, Azia S, Coyne, Carolyn B
openaire +2 more sources
Comparative and evolutionary analysis of RIP kinases in immune responses
Frontiers in Genetics, 2022 The group of receptor-interacting protein (RIP) kinases has seven members (RIPK1–7), with one homologous kinase domain but distinct non-kinase regions.
Shangge Lv +8 more
doaj +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source