Results 11 to 20 of about 15,294 (209)
Nefrología (English Edition), 2023 Receptor interacting protein kinase 3 (RIPK3) is an intracellular kinase at the crossroads of cell death and inflammation. RIPK3 contains a RIP homotypic interaction motif (RHIM) domain which allows interactions with other RHIM-containing proteins and a ...
Juan Guerrero-Mauvecin +4 more
doaj +9 more sources
PRMT5-mediated regulatory arginine methylation of RIPK3
Cell Death Discovery, 2023 The TNF receptor-interacting protein kinases (RIPK)-1 and 3 are regulators of extrinsic cell death response pathways, where RIPK1 makes the cell survival or death decisions by associating with distinct complexes mediating survival signaling, caspase ...
Chanchal Chauhan +7 more
doaj +6 more sources
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +3 more sources
RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis [PDF]
Frontiers in Oncology, 2021 Receptor-interacting protein 3 (RIPK3), a member of the family of serine/threonine protein kinases, emerged as a critical regulator of necroptosis. Downregulated expression of RIPK3 is correlated with poor prognosis in multiple tumor types. Here, we show
Qun Zhao +12 more
doaj +3 more sources
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
Cell Death and Disease, 2022 Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase RIPK3.
Yanxiang Meng +7 more
doaj +2 more sources
RIPK1 and RIPK3 - emerging targets in cancer?
Molecular and Cellular Therapies, 2018 RIPK1 and RIPK3 are homologous Ser/Thr kinases, which act in concert within the necrosome complexes to initiate a sub-type of regulated necrosis, termed necroptosis.
Suraj Shah, Kerem Gurol, Alexei Degterev
core +3 more sources
RIPK3 Contributes to Thyroid Hormone-Induced Photoreceptor Degeneration [PDF]
International Journal of Molecular SciencesThyroid hormone (TH) regulates cell proliferation, differentiation, and metabolism. Increased TH levels in circulation are associated with a higher incidence of age-related macular degeneration.
Yun Le +9 more
core +3 more sources
Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair [PDF]
Cell Reports, 2017 Receptor interacting protein kinase 3 (RIPK3) induces necroptosis, a type of regulated necrosis, through its kinase domain and receptor interacting protein (RIP) homotypic interaction motif (RHIM).
Kenta Moriwaki +4 more
doaj +3 more sources
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis [PDF]
Nature Communications, 2021 The pseudokinase MLKL is activated by the upstream kinase RIPK3 in the necroptotic pathway but the structural basis of MLKL activation is not well understood yet.
Yanxiang Meng +14 more
doaj +2 more sources
Spotted: RIPK3 and MLKL assembling necroptotic complexes
Open BiologyNecroptosis is a form of regulated cell death (RCD) that evolved as a defence against pathogenic infection. Unlike caspase-dependent RCD, necroptosis, in its canonical form, is driven by receptor-interacting protein kinase 1 and 3 (RIPK1 and RIPK3 ...
Martínez-Osorio, V. +2 more
core +4 more sources