Results 11 to 20 of about 17,938 (260)
GADD45β inhibits RIPK3-mediated NF-κB activation by interfering with NEMO-RIPK1-RIPK3 interactions [PDF]
Cell Death DiscoveryNecroptosis is a highly inflammatory form of regulated cell death driven by Receptor-Interacting Protein Kinase 3 (RIPK3), which plays a crucial role in immune responses, inflammatory diseases, and tumor microenvironment modulation.
Carmela Casale +10 more
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Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death [PDF]
iScience, 2022 Summary: Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated necroptosis and caspase-8-dependent apoptosis. However, the post-translational control of RIPK3
Daniel Frank +23 more
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NefrologíaReceptor interacting protein kinase 3 (RIPK3) is an intracellular kinase at the crossroads of cell death and inflammation. RIPK3 contains a RIP homotypic interaction motif (RHIM) domain which allows interactions with other RHIM-containing proteins and a ...
Juan Guerrero-Mauvecin +4 more
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PRMT5-mediated regulatory arginine methylation of RIPK3
Cell Death Discovery, 2023 The TNF receptor-interacting protein kinases (RIPK)-1 and 3 are regulators of extrinsic cell death response pathways, where RIPK1 makes the cell survival or death decisions by associating with distinct complexes mediating survival signaling, caspase ...
Chanchal Chauhan +7 more
doaj +5 more sources
RIPK3 Slams the Brake on Leukemogenesis [PDF]
Cancer Cell, 2016 Evasion of cell death is a key hallmark of cancers. In this issue of Cancer Cell, Höckendorf and colleagues identified RIPK3, an essential kinase for necroptosis, as having a key role in inhibiting acute myeloid leukemia development.
Francis K.L. Chan
openalex +3 more sources
Redox Biology, 2019 The basic pathophysiological mechanisms underlying septic cardiomyopathy have not yet been completely clarified. Disease-specific treatments are lacking, and care is still based on supportive modalities.
Jiankai Zhong, Ying Tan, Jichen Liu
exaly +3 more sources
The Role of RIPK1 and RIPK3 in Cardiovascular Disease [PDF]
International Journal of Molecular Sciences, 2020 Cardiovascular diseases, including peripheral arterial and venous disease, myocardial infarction, and stroke, are the number one cause of death worldwide annually. In the last 20 years, the role of necroptosis, a newly identified form of regulated necrotic cell death, in cardiovascular disease has come to light.
Elise DeRoo, Ting Zhou, Bo Liu
openalex +4 more sources
CK1α, CK1δ, and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Shuzhen Liu, She Chen, Zhigao Wang
exaly +2 more sources
Structure-Based Virtual Screening of Cinnamic Acid Analogs Against RIPK3: Implications for Anti-Inflammatory Drug Discovery [PDF]
Avicenna Journal of Medical Biochemistry, 2023 Background: A common oral inflammatory disease known as apical periodontitis (AP) is caused by the intrusion of microorganisms into the dental pulp, resulting in an inflammatory response and bone degradation in periapical tissues.
Elham Khoshbin +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: To investigate the pathophysiology of age-related hearing loss (ARHL) and the mechanism of resveratrol (RSV) in prevention and treatment of ARHL.Methods: C57BL/6 mice of different ages were used in this study. Auditory brainstem response (ABR)
Zeyin Yang +5 more
doaj +1 more source