Results 11 to 20 of about 2,978 (173)
Nefrología (English Edition), 2023 Receptor interacting protein kinase 3 (RIPK3) is an intracellular kinase at the crossroads of cell death and inflammation. RIPK3 contains a RIP homotypic interaction motif (RHIM) domain which allows interactions with other RHIM-containing proteins and a ...
Juan Guerrero-Mauvecin +4 more
doaj +9 more sources
PRMT5-mediated regulatory arginine methylation of RIPK3
Cell Death Discovery, 2023 The TNF receptor-interacting protein kinases (RIPK)-1 and 3 are regulators of extrinsic cell death response pathways, where RIPK1 makes the cell survival or death decisions by associating with distinct complexes mediating survival signaling, caspase ...
Chanchal Chauhan +7 more
doaj +6 more sources
RIPK3: Beyond Necroptosis. [PDF]
Immunity, 2021 In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby
Evans, Azia S, Coyne, Carolyn B
core +3 more sources
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
Cell Death and Disease, 2022 Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase RIPK3.
Yanxiang Meng +7 more
doaj +2 more sources
RIPK1 and RIPK3 - emerging targets in cancer?
Molecular and Cellular Therapies, 2018 RIPK1 and RIPK3 are homologous Ser/Thr kinases, which act in concert within the necrosome complexes to initiate a sub-type of regulated necrosis, termed necroptosis.
Suraj Shah, Kerem Gurol, Alexei Degterev
core +3 more sources
RIPK3—a predictive marker for personalized immunotherapy? [PDF]
OncoImmunology, 2016 Cancer immunotherapy is an attractive therapeutic option but it is currently unclear which patient may benefit from such approaches. Using the model of cervical cancer, we have demonstrated that PolyIC-driven immunogenicity strictly depends on the ...
Sigrun Smola
core +4 more sources
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +2 more sources
Necroptosis induced by RIPK3 requires MLKL but not Drp1 [PDF]
Cell Death & Disease, 2014 Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro-apoptotic Bcl-2 family members Bax or Bak.
Vaux, DL +3 more
core +5 more sources
RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis [PDF]
Cell Death and Disease, 2023 Necroptosis facilitates cell death in a controlled manner and is employed by many cell types following injury. It plays a significant role in various liver diseases, albeit the cell-type-specific regulation of necroptosis in the liver and especially ...
Jessica Hoff +7 more
doaj +2 more sources
Spotted: RIPK3 and MLKL assembling necroptotic complexes
Open BiologyNecroptosis is a form of regulated cell death (RCD) that evolved as a defence against pathogenic infection. Unlike caspase-dependent RCD, necroptosis, in its canonical form, is driven by receptor-interacting protein kinase 1 and 3 (RIPK1 and RIPK3 ...
Martínez-Osorio, V. +2 more
core +4 more sources