Results 1 to 10 of about 15,574 (187)
O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis [PDF]
Frontiers in Immunology, 2023 Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O ...
Junghwa Seo +16 more
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Exogenous hydrogen sulfide alleviates cerebral ischemia/reperfusion injury via inhibiting RIPK1-mediated neuronal necroptosis and ROS overaccumulation [PDF]
Frontiers in Molecular BiosciencesBackgroundCerebral I/R injury is a significant pathological factor contributing to neuronal death and neurological dysfunction following stroke. Necroptosis and excessive oxidative stress are pivotal mechanisms that drive ischemic neuronal damage.
Chuanjiang Huang +7 more
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Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023 Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış +3 more
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Necroptosis: A Novel Pathway in Neuroinflammation
Frontiers in Pharmacology, 2021 Neuroinflammation is a complex inflammatory process in the nervous system that is expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis that triggers innate immune responses by rupturing dead cells and releasing ...
Ziyu Yu +4 more
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Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1
Frontiers in Cellular and Infection Microbiology, 2022 Dengue virus (DENV) infection is the most prevalent arthropod-borne virus disease and is endemic in more than 100 countries. Several DENV proteins have been shown to target crucial human host proteins to evade innate immune responses and establish a ...
Darshika J. Udawatte +4 more
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npj Breast Cancer, 2021 The triple-negative breast carcinoma (TNBC) is the most aggressive subtype of breast cancer. In TNBC, Aquaporin 1 (AQP1), a water-transporting transmembrane protein, is aberrantly enriched in cytoplasm and causes tumor cell death evasion.
Zhuming Yin +7 more
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The phospho-barcode of RIPK1: complementarity or redundancy?
Molecular & Cellular Oncology, 2020 Receptor interacting serine/threonine kinase 1 (RIPK1) is the central mediator of tumor necrosis factor (TNF) signaling. It regulates both pro-survival/pro-inflammatory and cell death pathways.
Wenxian Wu, Björn Stork
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Neuroscience Insights, 2020 Introduction: Necroptosis is a form of programmed cell death that is different from apoptotic cell death. Receptor-interacting protein kinase 1 (RIPK1) plays a particularly important function in necroptosis execution.
Haruo Kanno +4 more
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Cell Death and Disease, 2022 Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are critical regulators of programmed necrosis or necroptosis. However, the role of the RIPK1/RIPK3 signaling pathway in myocardial fibrosis and related diabetic cardiomyopathy is still unclear.
Shigang Qiao +9 more
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MLKL Regulates Rapid Cell Death-independent HMGB1 Release in RSV Infected Airway Epithelial Cells
Frontiers in Cell and Developmental Biology, 2022 Respiratory syncytial virus (RSV)-induced bronchiolitis is a significant contributor to infant morbidity and mortality. Previously, we identified that necroptosis, a pro-inflammatory form of cell death mediated by receptor-interacting serine/threonine ...
Jennifer Simpson +5 more
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