Results 1 to 10 of about 922 (160)
Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance While the critical role of RIPK1 kinase activity in mediating necroptosis and RIPK1-dependent apoptosis has been established, we still know little about how the nonkinase domains of RIPK1 regulate its kinase activity. Establishing the role of RIPK1-death domain (DD) in mediating RIPK1 activation and formation of complex ...
Huibing Wang, Zhen Liu, Huyan Meng
exaly +3 more sources
Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation [PDF]
Molecular Metabolism, 2023 Objectives: Type 1 diabetes (T1D) is caused by progressive immune-mediated loss of insulin-producing β-cells. Inflammation is detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as mechanisms of β-cell ...
Tatiana Takiishi +7 more
doaj +3 more sources
Targeting RIPK1 for the treatment of human diseases [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance RIPK1 plays a critical role in mediating deleterious responses downstream of TNFR1. RIPK1 inhibitors have been progressed successfully past human phase I clinical studies. This paper discusses why RIPK1 inhibitors present an opportunity for developing oral drugs for a range of human degenerative and inflammatory diseases,
Alexei Degterev +2 more
exaly +3 more sources
Cell Death DiscoveryRIPK1 (Receptor-interacting serine/threonine-protein kinase 1) is fundamental in regulating cell proliferation, programmed cell death, and inflammation.
Ning Nan +6 more
doaj +3 more sources
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023 Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış +3 more
doaj +1 more source
The double life of RIPK1 [PDF]
Molecular & Cellular Oncology, 2015 We have recently identified receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) as an oncogenic driver in melanoma in addition to its well-established role in controlling cell survival and death. Our studies show that RIPK1 promotes melanoma cell proliferation through a positive feedback loop of NFKB1-BIRC2/BIRC3-RIPK1 powered by autocrine ...
Jin, Lei +4 more
openaire +2 more sources
IAPs: Guardians of RIPK1 [PDF]
Cell Death & Differentiation, 2011 Deregulation of innate immune signalling and cell death form the basis of most human disease pathogenesis. Inhibitor of APoptosis (IAP) protein-family members are frequently overexpressed in cancer and contribute to tumour cell survival, chemo-resistance, disease progression and poor prognosis. Although best known for their ability to regulate caspases,
M, Darding, P, Meier
openaire +2 more sources
MLKL Regulates Rapid Cell Death-independent HMGB1 Release in RSV Infected Airway Epithelial Cells
Frontiers in Cell and Developmental Biology, 2022 Respiratory syncytial virus (RSV)-induced bronchiolitis is a significant contributor to infant morbidity and mortality. Previously, we identified that necroptosis, a pro-inflammatory form of cell death mediated by receptor-interacting serine/threonine ...
Jennifer Simpson +5 more
doaj +1 more source
Advances in RIPK1 kinase inhibitors
Frontiers in Pharmacology, 2022 Programmed necrosis is a new modulated cell death mode with necrotizing morphological characteristics. Receptor interacting protein 1 (RIPK1) is a critical mediator of the programmed necrosis pathway that is involved in stroke, myocardial infarction, fatal systemic inflammatory response syndrome, Alzheimer’s disease, and malignancy.
Lu Chen +13 more
openaire +3 more sources
npj Breast Cancer, 2021 The triple-negative breast carcinoma (TNBC) is the most aggressive subtype of breast cancer. In TNBC, Aquaporin 1 (AQP1), a water-transporting transmembrane protein, is aberrantly enriched in cytoplasm and causes tumor cell death evasion.
Zhuming Yin +7 more
doaj +1 more source