Results 11 to 20 of about 3,236 (190)
O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis [PDF]
Frontiers in Immunology, 2023 Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O ...
Junghwa Seo +16 more
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Viral Suppression of RIPK1-Mediated Signaling [PDF]
mBio, 2021 Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has emerged as a key upstream regulator of cell death and inflammation. RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1), Toll-like receptor 3 (TLR3), TLR4, retinoic acid-inducible gene 1 (RIG-I)/melanoma ...
Darshika J. Udawatte, Alan L. Rothman
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The Involvement of RIPK1 in Alopecia Areata
International Journal of Molecular SciencesWe have previously demonstrated that receptor-interacting serine threonine kinase 1 (RIPK1) is expressed in hair follicles and regulates the hair cycle. In a mouse model, RIPK1 inhibitors also accelerated the telogen-to-anagen transition and elongated the anagen period. Here, we first investigated the involvement of RIPK1 in alopecia areata (AA).
Hyunju Kim +6 more
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RIPK1 and RIPK3 - emerging targets in cancer?
Molecular and Cellular Therapies, 2018 RIPK1 and RIPK3 are homologous Ser/Thr kinases, which act in concert within the necrosome complexes to initiate a sub-type of regulated necrosis, termed necroptosis. Necroptosis has gradually emerged as a highly clinically relevant form of necrosis, which can be targeted therapeutically.
Kerem Gurol, Suraj Shah, Alexei Degterev
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The structure of mouse RIPK1 RHIM-containing domain as a homo-amyloid and in RIPK1/RIPK3 complex [PDF]
Nature CommunicationsReceptor-interacting protein kinase 1 (RIPK1) is a therapeutic target in treating neurodegenerative diseases and cancers. RIPK1 has three distinct functional domains, with the center domain containing a receptor-interacting protein homotypic interaction motif (RHIM), which mediates amyloid formation.
Jing Liu +6 more
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Development of a RIPK1 degrader to enhance antitumor immunity [PDF]
Nature CommunicationsThe scaffolding function of receptor interacting protein kinase 1 (RIPK1) confers intrinsic and extrinsic resistance to immune checkpoint blockades (ICBs) and emerges as a promising target for improving cancer immunotherapies.
Xin Yu +12 more
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FDA-approved phensuximide inhibits RIPK1-dependent immunogenic cell death
Cell Death and DiseaseReceptor-interacting serine/threonine kinase 1 (RIPK1) is a pivotal protein controlling cell death and inflammation. RIPK1 is an attractive therapeutic target, given that the inhibition of RIPK1 kinase activity has been shown to be effective in animal ...
Byeong-Ju Kim +13 more
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Necroptosis: A Novel Pathway in Neuroinflammation
Frontiers in Pharmacology, 2021 Neuroinflammation is a complex inflammatory process in the nervous system that is expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis that triggers innate immune responses by rupturing dead cells and releasing ...
Ziyu Yu +4 more
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Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response. [PDF]
, 2022 RIPK1 is a master regulator of multiple cell death pathways, including apoptosis and necroptosis, and inflammation. Importantly, activation of RIPK1 has also been shown to promote the transcriptional induction of proinflammatory cytokines in cells ...
Manuel, Vica +12 more
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Neuroscience Insights, 2020 Introduction: Necroptosis is a form of programmed cell death that is different from apoptotic cell death. Receptor-interacting protein kinase 1 (RIPK1) plays a particularly important function in necroptosis execution.
Haruo Kanno +4 more
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