Results 11 to 20 of about 15,574 (187)

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential

Cell Reports, 2018
Summary: Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch between these distinct outcomes remain poorly defined.
Rebecca Feltham, Kunzah Jamal, Tencho Tenev, Gianmaria Liccardi, Isabel Jaco, Celia Monteiro Domingues, Otto Morris, Sidonie Wicky John, Alessandro Annibaldi, Marcella Widya, Conor J. Kearney, Danielle Clancy, Paul R. Elliott, Timo Glatter, Qi Qiao, Andrew J. Thompson, Alexey Nesvizhskii, Alexander Schmidt, David Komander, Hao Wu, Seamus Martin, Pascal Meier   +21 more
doaj   +2 more sources

Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation

Molecular Metabolism, 2023
Objectives: Type 1 diabetes (T1D) is caused by progressive immune-mediated loss of insulin-producing β-cells. Inflammation is detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as mechanisms of β-cell ...
Tatiana Takiishi, Peng Xiao, Marie Franchimont, Eduardo H. Gilglioni, Erick N. Arroba, Esteban N. Gurzov, Mathieu JM. Bertrand, Alessandra K. Cardozo   +7 more
doaj   +2 more sources

FDA-approved phensuximide inhibits RIPK1-dependent immunogenic cell death

Cell Death and Disease
Receptor-interacting serine/threonine kinase 1 (RIPK1) is a pivotal protein controlling cell death and inflammation. RIPK1 is an attractive therapeutic target, given that the inhibition of RIPK1 kinase activity has been shown to be effective in animal ...
Byeong-Ju Kim, Sun Mi Hong, Hyun-Jin Noh, Jihye Kim, Su-Yeon Seon, Jeong-Eun Lee, Da-Hye Jeong, Ju-Mi Park, Sejeong Park, Sanghoon Lee, Jaewoo Kang, Dakeun Lee, Michael J. Morgan, You-Sun Kim   +13 more
doaj   +2 more sources

RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models

Cells, 2023
Increasing evidence suggests a pivotal role of receptor-interacting protein kinase 1 (RIPK1), an initiator of necroptosis, in neuroinflammation. However, the precise role of RIPK1 in microglial activation remains unclear.
Do-Yeon Kim, Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Jae-Min Park, Jihee Lee Kang, Hee-Sun Kim   +6 more
doaj   +2 more sources

Development of a RIPK1 degrader to enhance antitumor immunity [PDF]

Nature Communications
The scaffolding function of receptor interacting protein kinase 1 (RIPK1) confers intrinsic and extrinsic resistance to immune checkpoint blockades (ICBs) and emerges as a promising target for improving cancer immunotherapies.
Xin Yu, Dong Lu, Xiaoli Qi, Rishi Ram Paudel, Hanfeng Lin, Bryan L. Holloman, Feng Jin, Longyong Xu, Lang Ding, Weiyi Peng, Meng C. Wang, Xi Chen, Jin Wang   +12 more
doaj   +2 more sources

To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function

Molecular & Cellular Oncology, 2018
Complex posttranslational modifications determine the effects of receptor-interacting protein kinase-1 (RIPK1) on cell survival and death. Studies from us and others have revealed a p38MAPK/MK2-dependent checkpoint in RIPK1 signaling.
Manoj B. Menon, Julia Gropengießer, Klaus Ruckdeschel, Matthias Gaestel   +3 more
doaj   +2 more sources

RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy

EMBO Reports
RIPK1 is a crucial regulator of cell survival, inflammation and cell death. Human RIPK1 deficiency leads to early-onset intestinal inflammation and peripheral T cell imbalance, though its role in αβT cell-mediated intestinal homeostasis remains unclear ...
Jelle Huysentruyt, Wolf Steels, Mario Ruiz Pérez, Bruno Verstraeten, Tatyana Divert, Kayleigh Flies, Kelly Lemeire, Nozomi Takahashi, Elke De Bruyn, Marie Joossens, Andrew S Brown, Bart N Lambrecht, Wim Declercq, Tom Vanden Berghe, Jonathan Maelfait, Peter Vandenabeele, Peter Tougaard   +16 more
doaj   +3 more sources

Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response. [PDF]

, 2022
RIPK1 is a master regulator of multiple cell death pathways, including apoptosis and necroptosis, and inflammation. Importantly, activation of RIPK1 has also been shown to promote the transcriptional induction of proinflammatory cytokines in cells ...
Manuel, Vica, Shan, Bing, Li, Wanjin, Zhu, Hong, Naito, Masanori, Mifflin, Lauren, Ravits, John, Wang, Huibing, Zou, Chengyu, Xu, Daichao, Hou, Zhaodong, Yuan, Junying, Zhang, Meng-Meng   +12 more
core   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

RIPK1 in Liver Parenchymal Cells Limits Murine Hepatitis during Acute CCl(4)-Induced Liver Injury

, 2022
Some life-threatening acute hepatitis originates from drug-induced liver injury (DILI). Carbon tetrachloride (CCl(4))-induced acute liver injury in mice is the widely used model of choice to study acute DILI, which pathogenesis involves a complex ...
Muhammad Farooq, Farooq, Muhammad, Piquet-Pellorce, Claire, Hameed, Huma, Huma Hameed, Dimanche-Boitrel, Marie-Thérèse, Jacques Le Seyec, Samson, Michel, Hamon, Annaïg, Claire Piquet-Pellorce, Le Seyec, Jacques, Marie-Thérèse Dimanche-Boitrel, Vuillier, Céline, Michel Samson, Ahmad, Muhammad Farooq, Céline Vuillier, Annaïg Hamon   +16 more
core   +1 more source