Results 11 to 20 of about 18,314 (233)
Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation
Molecular Metabolism, 2023 Objectives: Type 1 diabetes (T1D) is caused by progressive immune-mediated loss of insulin-producing β-cells. Inflammation is detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as mechanisms of β-cell ...
Tatiana Takiishi +7 more
doaj +3 more sources
RIPK1-Associated Inborn Errors of Innate Immunity [PDF]
Frontiers in Immunology, 2021 RIPK1 (receptor-interacting serine/threonine-protein kinase 1) is a key molecule for mediating apoptosis, necroptosis, and inflammatory pathways downstream of death receptors (DRs) and pattern recognition receptors (PRRs).
Jiahui Zhang +6 more
doaj +3 more sources
Cell Death DiscoveryRIPK1 (Receptor-interacting serine/threonine-protein kinase 1) is fundamental in regulating cell proliferation, programmed cell death, and inflammation.
Ning Nan +6 more
doaj +2 more sources
IAPs: Guardians of RIPK1 [PDF]
Cell Death & Differentiation, 2011 Deregulation of innate immune signalling and cell death form the basis of most human disease pathogenesis. Inhibitor of APoptosis (IAP) protein-family members are frequently overexpressed in cancer and contribute to tumour cell survival, chemo-resistance, disease progression and poor prognosis. Although best known for their ability to regulate caspases,
M, Darding, P, Meier
openaire +2 more sources
Advances in RIPK1 kinase inhibitors
Frontiers in Pharmacology, 2022 Programmed necrosis is a new modulated cell death mode with necrotizing morphological characteristics. Receptor interacting protein 1 (RIPK1) is a critical mediator of the programmed necrosis pathway that is involved in stroke, myocardial infarction, fatal systemic inflammatory response syndrome, Alzheimer’s disease, and malignancy.
Lu Chen +13 more
openaire +3 more sources
The double life of RIPK1 [PDF]
Molecular & Cellular Oncology, 2015 We have recently identified receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) as an oncogenic driver in melanoma in addition to its well-established role in controlling cell survival and death. Our studies show that RIPK1 promotes melanoma cell proliferation through a positive feedback loop of NFKB1-BIRC2/BIRC3-RIPK1 powered by autocrine ...
Jin, Lei +4 more
openaire +2 more sources
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation [PDF]
, 2020 Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases.
Bertrand, Mathieu +11 more
core +1 more source
Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance While the critical role of RIPK1 kinase activity in mediating necroptosis and RIPK1-dependent apoptosis has been established, we still know little about how the nonkinase domains of RIPK1 regulate its kinase activity. Establishing the role of RIPK1-death domain (DD) in mediating RIPK1 activation and formation of complex ...
Huyan Meng +11 more
openaire +2 more sources
RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development
Frontiers in Immunology, 2023 Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors.
Thomas Hägglöf +6 more
doaj +1 more source
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]
, 2020 Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien +12 more
core +2 more sources