Results 41 to 50 of about 3,236 (190)

Axonal Degeneration: RIPK1 Multitasking in ALS [PDF]

Current Biology, 2016
A recent study reports that microglia and oligodendrocytes promote motor neuron degeneration by inducing inflammation and necroptosis in a manner dependent on receptor-interacting kinase 1 (RIPK1). These findings could be significant for our understanding of the neurobiology and treatment of neurodegenerative diseases like amyotrophic lateral sclerosis.
Kristin, Politi, Serge, Przedborski
openaire   +2 more sources

Pancreatic beta cells are resistant to RIPK1 kinase-mediated death

, 2022
Background and aims: Type 1 diabetes (T1D) is caused by progressive immune-mediated loss of insulin-producing β-cells. Inflammation is very detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as a ...
Xiao, Peng, Takiishi, Tatiana, Gurzov, Esteban Nicolas, Bertrand, Mathieu, Cardozo, Alessandra K   +4 more
core   +1 more source

Inhibition of Necroptosis in Acute Pancreatitis: Screening for RIPK1 Inhibitors

, 2022
This work utilizes the anthraquinone (AQ) database to identify potential inhibitors of the RIPK1 protein for developing medicines targeting AP-associated necroptosis.
Ping Wu, Yan Liu, Hailong Chen, Yin Wang, Yalan Luo, Jiaqi Yao, Xiaojun Liu, Qingping Wen   +7 more
core   +1 more source

Necroptosis in bacterial infections

Frontiers in Immunology
Necroptosis, a recently discovered form of cell-programmed death that is distinct from apoptosis, has been confirmed to play a significant role in the pathogenesis of bacterial infections in various animal models. Necroptosis is advantageous to the host,
Xing Yu, Jin Yuan, Linxi Shi, Shuying Dai, Lei Yue, Min Yan   +5 more
doaj   +1 more source

Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

Molecular & Cellular Oncology, 2019
A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells.
Shawn T. Beug, Robert G. Korneluk, Eric C. LaCasse   +2 more
doaj   +1 more source

TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis

The Journal of Clinical Investigation, 2022
Mutations in TGF-β–activated kinase 1 binding protein 2 (TAB2) have been implicated in the pathogenesis of dilated cardiomyopathy and/or congenital heart disease in humans, but the underlying mechanisms are currently unknown.
Haifeng Yin, Xiaoyun Guo, Yi Chen, Yachang Zeng, Xiaoliang Mo, Siqi Hong, Hui He, Jing Li, Rachel Steinmetz, Qinghang Liu   +9 more
doaj   +1 more source

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis [PDF]

Nature Communications, 2019
AbstractThe ubiquitination status of RIPK1 is considered to be critical for cell fate determination. However, the in vivo role for RIPK1 ubiquitination remains undefined. Here we show that mice expressing RIPK1K376R which is defective in RIPK1 ubiquitination die during embryogenesis.
Xixi Zhang, Haiwei Zhang, Chengxian Xu, Xiaoming Li, Ming Li, Xiaoxia Wu, Wenjuan Pu, Bin Zhou, Haikun Wang, Dali Li, Qiurong Ding, Hao Ying, Hui Wang, Haibing Zhang   +13 more
openaire   +3 more sources

DataSheet_1_O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis.pdf

, 2023
Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O ...
Han Byeol Kim (6657353), Jin Won Cho (5480786), Yong-ho Lee (295960), Suena Ji (16241414), Yeolhoe Kim (16241411), Hyeryeon Jung (10726889), Won Ho Yang (10066546), Junghwa Seo (10066531), Injae Shin (1419676), Eugene C. Yi (177154)   +9 more
core   +1 more source

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease [PDF]

, 2020
RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage1-
Yang, D, Herold, MJ, Lalaoui, N, Gadina, M, Kuehn, HS, Silke, N, Etemadi, N, Mullikin, JC, Voss, AK, Silke, J, Zaal, KJM, Shield-Artin, K, Kueh, AJ, Zhou, Q, Lawlor, KE, Wachsmuth, L, Dmitrieva, NI, Gutierrez-Cruz, G, Stone, DL, Hawkins, ED, Shum, AK, Oda, H, Jones, A, Beck, DB, Aksentijevich, I, Pinto-Patarroyo, GP, Boehm, M, Barham, BK, Anderton, H, Hall, C, Chae, JJ, Zheng, L, Blake, MD, Liu, L, Wang, H, Boyden, SE, Masters, SL, Rosenzweig, SD, Romeo, TM, Kastner, DL, Tsai, WL, Pasparakis, M, McKenzie, M, Ombrello, AK, Light, A, Chau, D, Biben, C, Kratina, T, Stoffels, M, Lenardo, MJ, Hoffmann, PM, Gross, AJ, Wood, GM, Moura, NS   +53 more
core   +2 more sources

Rictor/mTORC2 signaling pathway protects endogenous neural stem cells to promote recovery after spinal cord injury

Neural Regeneration Research
Although endogenous neural stem cells represent a promising target for noninvasive spinal cord injury repair, inflammatory lesion environments frequently trigger their death.
Kuileung Tong, Shiming Li, Guoliang Chen, Dacheng He, Chengkai Lin, Yuhang Li, Ningning Chen   +6 more
doaj   +1 more source