Results 51 to 60 of about 18,314 (233)
Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]
, 2020 Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P. +7 more
core +2 more sources
Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1 [PDF]
Cell, 2018 Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together ...
Haiyang, Yu, Don W, Cleveland
openaire +2 more sources
Clinical phenotype of a Chinese patient with RIPK1 deficiency due to novel mutation
Genes and Diseases, 2020 Accumulating evidence indicates that RIPK1 is associated with inflammation and apoptotic. RIPK1 deficiency leads to proinflammatory signaling impaired. However, only few patients with homozygous loss-of-function mutation in RIPK1 gene had been reported ...
Li Lin +7 more
doaj +1 more source
Necroptosis in bacterial infections
Frontiers in ImmunologyNecroptosis, a recently discovered form of cell-programmed death that is distinct from apoptosis, has been confirmed to play a significant role in the pathogenesis of bacterial infections in various animal models. Necroptosis is advantageous to the host,
Xing Yu +5 more
doaj +1 more source
Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis [PDF]
, 2017 Necroptosis is a regulated form of cell death involved in several disease models including in particular liver diseases. Receptor-interacting protein kinases, RIPK1 and RIPK3, are the main serine/threonine kinases driving this cell death pathway.
Afonso +47 more
core +5 more sources
RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation [PDF]
, 2018 In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles of RIPK1 in regulating hematopoiesis and macrophage differentiation, proinflammatory activation, and cell death
Buchrieser, Julian +7 more
core +1 more source
Primidone blocks RIPK1-driven cell death and inflammation [PDF]
Cell Death & Differentiation, 2020 AbstractThe receptor-interacting serine/threonine protein kinase 1 (RIPK1) is a key mediator of regulated cell death and inflammation. Recent studies suggest that RIPK1 inhibition would fundamentally improve the therapy of RIPK1-dependent organ damage in stroke, myocardial infarction, kidney failure, and systemic inflammatory response syndrome ...
Riebeling, Theresa +18 more
openaire +5 more sources
TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages
Frontiers in Cell and Developmental Biology, 2019 Macrophages stand in the first line of defense against a variety of pathogens but are also involved in the maintenance of tissue homeostasis. To fulfill their functions macrophages sense a broad range of pathogen- and damage-associated molecular patterns
Harald Wajant, Daniela Siegmund
doaj +1 more source
Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma. [PDF]
, 2014 Ovarian cancer patients are typically treated with carboplatin and paclitaxel, but suffer a high rate of relapse with recalcitrant disease. This challenge has fostered the development of novel approaches to treatment, including antagonists of the ...
Axelrod, J +10 more
core +2 more sources
Stem Cells International, 2021 Survival of mesenchymal stem cells in the bone marrow is essential for bone marrow microenvironment homeostasis, but the molecular mechanisms remain poorly understood.
Qing Tian +7 more
doaj +1 more source