Results 31 to 40 of about 15,574 (187)

Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury

International Journal of Hyperthermia, 2020
Background Worldwide heat stroke incidence has increased in recent years and is associated with high morbidity and mortality. Therefore, it is critical to identify mechanisms that mediate heat stroke.
Li Li, Hongping Tan, Zhimin Zou, Jian Gong, Junjie Zhou, Na Peng, Lei Su, Marc Maegele, Daozhang Cai, Zhengtao Gu   +9 more
doaj   +1 more source

Enigmatic role of RIPK1 in leukemia

, 2023
Introduction Cell survival, inflammation and death are essential physiological events for maintaining cellular homeostasis and for preventing disease, especially cancer.
Vincenza Capone, Laura Della Torre, Antonio Beato, Lucia Altucci, Vincenzo Carafa   +4 more
core  

Necroptosis in bacterial infections

Frontiers in Immunology
Necroptosis, a recently discovered form of cell-programmed death that is distinct from apoptosis, has been confirmed to play a significant role in the pathogenesis of bacterial infections in various animal models. Necroptosis is advantageous to the host,
Xing Yu, Jin Yuan, Linxi Shi, Shuying Dai, Lei Yue, Min Yan   +5 more
doaj   +1 more source

Rictor/mTORC2 signaling pathway protects endogenous neural stem cells to promote recovery after spinal cord injury

Neural Regeneration Research
Although endogenous neural stem cells represent a promising target for noninvasive spinal cord injury repair, inflammatory lesion environments frequently trigger their death.
Kuileung Tong, Shiming Li, Guoliang Chen, Dacheng He, Chengkai Lin, Yuhang Li, Ningning Chen   +6 more
doaj   +1 more source

TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages

Frontiers in Cell and Developmental Biology, 2019
Macrophages stand in the first line of defense against a variety of pathogens but are also involved in the maintenance of tissue homeostasis. To fulfill their functions macrophages sense a broad range of pathogen- and damage-associated molecular patterns
Harald Wajant, Daniela Siegmund
doaj   +1 more source

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

Nature Communications, 2019
RIPK1 kinase activity is known to transduce a death signal, but the molecular mechanisms that normally prevent RIPK1 activation are unclear. Here, the authors report that IKK-mediated phosphorylation on RIPK1 Ser25 directly represses its enzymatic ...
Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky, Mathieu J. M. Bertrand   +14 more
doaj   +1 more source

Receptor-interacting protein kinase 1 (RIPK1) regulates cervical cancer cells via NF-κB–TNF-α pathway: An in vitro study

Translational Oncology, 2023
Introduction: Cervical cancer (CC) is associated with high morbidity and mortality rates in women. Members of the receptor-interacting protein kinase (RIPK) family are important regulators of inflammation and cell death.
Wenqi Bai, Fengjie Cui, Zihan Wang, Xianhua Gu, Xiaojing Fang, Li Zhou, Suyang Guo   +6 more
doaj   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

The structure of mouse RIPK1 RHIM-containing domain as a homo-amyloid and in RIPK1/RIPK3 complex [PDF]

Receptor-interacting protein kinase 1 (RIPK1) is a therapeutic target in treating neurodegenerative diseases and cancers. RIPK1 has three distinct functional domains, with the center domain containing a receptor-interacting protein homotypic interaction ...
Zhang, Jing, Wang, Jian, Liu, Jing, Li, Bing, Wu, Xia-lian, Wang, Hua-yi, Lu, Jun-xia   +6 more
core   +1 more source