Results 31 to 40 of about 3,236 (190)
RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development
Frontiers in Immunology, 2023 Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors.
Thomas Hägglöf +6 more
doaj +1 more source
The Role of RIPK1 and RIPK3 in Cardiovascular Disease [PDF]
International Journal of Molecular Sciences, 2020 Cardiovascular diseases, including peripheral arterial and venous disease, myocardial infarction, and stroke, are the number one cause of death worldwide annually. In the last 20 years, the role of necroptosis, a newly identified form of regulated necrotic cell death, in cardiovascular disease has come to light.
Elise DeRoo, Ting Zhou, Bo Liu
openaire +2 more sources
TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages
Frontiers in Cell and Developmental Biology, 2019 Macrophages stand in the first line of defense against a variety of pathogens but are also involved in the maintenance of tissue homeostasis. To fulfill their functions macrophages sense a broad range of pathogen- and damage-associated molecular patterns
Harald Wajant, Daniela Siegmund
doaj +1 more source
Targeting RIPK1 kinase for modulating inflammation in human diseases
Frontiers in Immunology, 2023 Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) is a master regulator of TNFR1 signaling in controlling cell death and survival. While the scaffold of RIPK1 participates in the canonical NF-κB pathway, the activation of RIPK1 kinase ...
Wanjin Li, Junying Yuan
doaj +1 more source
RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis [PDF]
, 2014 SummaryUpon ligand binding, RIPK1 is recruited to tumor necrosis factor receptor superfamily (TNFRSF) and Toll-like receptor (TLR) complexes promoting prosurvival and inflammatory signaling.
Murphy, James M. +31 more
core +1 more source
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death [PDF]
, 2017 TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α, and its downstream effector kinase MK2, thereby promoting ...
Tenev, T +33 more
core +1 more source
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
, 2021 Full author list omitted for brevity. For the full list of authors, see article.Receptor interacting protein kinase 1 (RIPK1) mediates cell death and inflammatory signaling and is increased in multiple sclerosis (MS) brain samples.
Ofengeim, Dimitry +4 more
core +1 more source
Molecular & Cellular Oncology, 2018 For cancer cells to survive during extracellular matrix (ECM)-detachment, they must inhibit anoikis and rectify metabolic deficiencies that lead to the induction of non-apoptotic cell death.
Mark A. Hawk, Zachary T. Schafer
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Necroptosis, The Double-Edged Sword and Its Therapeutic Implications in Cancer [PDF]
Archives of Pharmaceutical Sciences Ain Shams UniversityNecroptosis is a regulated cell death technique that eliminates cancer cells that are resistant to apoptosis, without requiring caspase. Necroptosis is implicated in several physiological and pathological processes.
Amer, Rana A. +3 more
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Discovery of a cooperative mode of inhibiting RIPK1 kinase
Cell Discovery, 2021 RIPK1, a death domain-containing kinase, has been recognized as an important therapeutic target for inhibiting apoptosis, necroptosis, and inflammation under pathological conditions.
Huyan Meng +19 more
doaj +1 more source