Results 21 to 30 of about 15,574 (187)
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
, 2021 Full author list omitted for brevity. For the full list of authors, see article.Receptor interacting protein kinase 1 (RIPK1) mediates cell death and inflammatory signaling and is increased in multiple sclerosis (MS) brain samples.
Ofengeim, Dimitry +4 more
core +1 more source
Targeting RIPK1 kinase for modulating inflammation in human diseases
Frontiers in Immunology, 2023 Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) is a master regulator of TNFR1 signaling in controlling cell death and survival. While the scaffold of RIPK1 participates in the canonical NF-κB pathway, the activation of RIPK1 kinase ...
Wanjin Li, Junying Yuan
doaj +1 more source
RIPK1-Associated Inborn Errors of Innate Immunity
Frontiers in Immunology, 2021 RIPK1 (receptor-interacting serine/threonine-protein kinase 1) is a key molecule for mediating apoptosis, necroptosis, and inflammatory pathways downstream of death receptors (DRs) and pattern recognition receptors (PRRs).
Jiahui Zhang +6 more
doaj +1 more source
Viral Suppression of RIPK1-Mediated Signaling [PDF]
, 2021 Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has emerged as a key upstream regulator of cell death and inflammation. RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1)
Alan L. Rothman +3 more
core +1 more source
Necroptosis, The Double-Edged Sword and Its Therapeutic Implications in Cancer [PDF]
Archives of Pharmaceutical Sciences Ain Shams UniversityNecroptosis is a regulated cell death technique that eliminates cancer cells that are resistant to apoptosis, without requiring caspase. Necroptosis is implicated in several physiological and pathological processes.
Amer, Rana A. +3 more
doaj +1 more source
RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development
Frontiers in Immunology, 2023 Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors.
Thomas Hägglöf +6 more
doaj +1 more source
Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
Molecular & Cellular Oncology, 2019 A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells.
Shawn T. Beug +2 more
doaj +1 more source
The Journal of Clinical Investigation, 2022 Mutations in TGF-β–activated kinase 1 binding protein 2 (TAB2) have been implicated in the pathogenesis of dilated cardiomyopathy and/or congenital heart disease in humans, but the underlying mechanisms are currently unknown.
Haifeng Yin +9 more
doaj +1 more source
Discovery of a cooperative mode of inhibiting RIPK1 kinase
Cell Discovery, 2021 RIPK1, a death domain-containing kinase, has been recognized as an important therapeutic target for inhibiting apoptosis, necroptosis, and inflammation under pathological conditions.
Huyan Meng +19 more
doaj +1 more source