Results 21 to 30 of about 12,004 (149)

Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation

Molecular Metabolism, 2023
Objectives: Type 1 diabetes (T1D) is caused by progressive immune-mediated loss of insulin-producing β-cells. Inflammation is detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as mechanisms of β-cell ...
Tatiana Takiishi, Peng Xiao, Marie Franchimont, Eduardo H. Gilglioni, Erick N. Arroba, Esteban N. Gurzov, Mathieu JM. Bertrand, Alessandra K. Cardozo   +7 more
doaj   +1 more source

RIPK1-dependent mitophagy: A novel mechanism to eliminate cells detached from the extracellular matrix

Molecular & Cellular Oncology, 2018
For cancer cells to survive during extracellular matrix (ECM)-detachment, they must inhibit anoikis and rectify metabolic deficiencies that lead to the induction of non-apoptotic cell death.
Mark A. Hawk, Zachary T. Schafer
doaj   +1 more source

RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models

Cells, 2023
Increasing evidence suggests a pivotal role of receptor-interacting protein kinase 1 (RIPK1), an initiator of necroptosis, in neuroinflammation. However, the precise role of RIPK1 in microglial activation remains unclear.
Do-Yeon Kim, Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Jae-Min Park, Jihee Lee Kang, Hee-Sun Kim   +6 more
doaj   +1 more source

Necroptosis, The Double-Edged Sword and Its Therapeutic Implications in Cancer [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Necroptosis is a regulated cell death technique that eliminates cancer cells that are resistant to apoptosis, without requiring caspase. Necroptosis is implicated in several physiological and pathological processes.
Amer, Rana A., Kamal, Amany M., El-shemy, Reham A. A., El-Mesallamy, Hala O.   +3 more
doaj   +1 more source

Necroptosis in bacterial infections

Frontiers in Immunology
Necroptosis, a recently discovered form of cell-programmed death that is distinct from apoptosis, has been confirmed to play a significant role in the pathogenesis of bacterial infections in various animal models. Necroptosis is advantageous to the host,
Xing Yu, Jin Yuan, Linxi Shi, Shuying Dai, Lei Yue, Min Yan   +5 more
doaj   +1 more source

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

Rictor/mTORC2 signaling pathway protects endogenous neural stem cells to promote recovery after spinal cord injury

Neural Regeneration Research
Although endogenous neural stem cells represent a promising target for noninvasive spinal cord injury repair, inflammatory lesion environments frequently trigger their death.
Kuileung Tong, Shiming Li, Guoliang Chen, Dacheng He, Chengkai Lin, Yuhang Li, Ningning Chen   +6 more
doaj   +1 more source

Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

Molecular & Cellular Oncology, 2019
A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells.
Shawn T. Beug, Robert G. Korneluk, Eric C. LaCasse   +2 more
doaj   +1 more source

Clinical phenotype of a Chinese patient with RIPK1 deficiency due to novel mutation

Genes and Diseases, 2020
Accumulating evidence indicates that RIPK1 is associated with inflammation and apoptotic. RIPK1 deficiency leads to proinflammatory signaling impaired. However, only few patients with homozygous loss-of-function mutation in RIPK1 gene had been reported ...
Li Lin, Ying Wang, Luyao Liu, Wenjing Ying, Wenjie Wang, Bijun Sun, Jinqiao Sun, Xiaochuan Wang   +7 more
doaj   +1 more source

Receptor-interacting protein kinase 1 (RIPK1) regulates cervical cancer cells via NF-κB–TNF-α pathway: An in vitro study

Translational Oncology, 2023
Introduction: Cervical cancer (CC) is associated with high morbidity and mortality rates in women. Members of the receptor-interacting protein kinase (RIPK) family are important regulators of inflammation and cell death.
Wenqi Bai, Fengjie Cui, Zihan Wang, Xianhua Gu, Xiaojing Fang, Li Zhou, Suyang Guo   +6 more
doaj   +1 more source