Results 21 to 30 of about 3,236 (190)
Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1
Frontiers in Cellular and Infection Microbiology, 2022 Dengue virus (DENV) infection is the most prevalent arthropod-borne virus disease and is endemic in more than 100 countries. Several DENV proteins have been shown to target crucial human host proteins to evade innate immune responses and establish a ...
Darshika J. Udawatte +4 more
doaj +1 more source
The phospho-barcode of RIPK1: complementarity or redundancy?
Molecular & Cellular Oncology, 2020 Receptor interacting serine/threonine kinase 1 (RIPK1) is the central mediator of tumor necrosis factor (TNF) signaling. It regulates both pro-survival/pro-inflammatory and cell death pathways.
Wenxian Wu, Björn Stork
doaj +1 more source
Regulation of RIPK1 Dependent Apoptosis and Necroptosis
, 2018 RIPK1 is a Ser/Thr kinase critically involved in mediating multiple signaling pathways activated by TNFa. When cells are stimulated by TNFa, RIPK1 is rapidly recruited to the intracellular domain of TNFR1 to form the TNF-RSC (TNF receptor signaling ...
Amin, Palak Prakash
core +4 more sources
The EMBO Reports, 2015 Receptor‐interacting protein kinase‐1 (RIPK1) sits at a signaling node controlling a number of functional pathways. These include both positive and negative control of apoptosis and necroptosis (a form of regulated necrosis). In this issue of EMBO Reports, Yonekawa and colleagues describe another function for RIPK1, the inhibition of autophagy via ERK ...
openaire +2 more sources
Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury
International Journal of Hyperthermia, 2020 Background Worldwide heat stroke incidence has increased in recent years and is associated with high morbidity and mortality. Therefore, it is critical to identify mechanisms that mediate heat stroke.
Li Li +9 more
doaj +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential
Cell Reports, 2018 Summary: Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch between these distinct outcomes remain poorly defined.
Rebecca Feltham +21 more
doaj +1 more source
Cell Death and Disease, 2022 Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are critical regulators of programmed necrosis or necroptosis. However, the role of the RIPK1/RIPK3 signaling pathway in myocardial fibrosis and related diabetic cardiomyopathy is still unclear.
Shigang Qiao +9 more
doaj +1 more source
RIPK1-Associated Inborn Errors of Innate Immunity
Frontiers in Immunology, 2021 RIPK1 (receptor-interacting serine/threonine-protein kinase 1) is a key molecule for mediating apoptosis, necroptosis, and inflammatory pathways downstream of death receptors (DRs) and pattern recognition receptors (PRRs).
Jiahui Zhang +6 more
doaj +1 more source