Results 31 to 40 of about 17,938 (260)
Primary cilia suppress Ripk3-mediated necroptosis [PDF]
Cell Death Discovery, 2022 AbstractCilia are sensory organelles that project from the surface of almost all cells. Nephronophthisis (NPH) and NPH-related ciliopathies are degenerative genetic diseases caused by mutation of cilia-associated genes. These kidney disorders are characterized by progressive loss of functional tubular epithelial cells which is associated with ...
Emilia Kieckhöfer +7 more
openaire +3 more sources
Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury
International Journal of Hyperthermia, 2020 Background Worldwide heat stroke incidence has increased in recent years and is associated with high morbidity and mortality. Therefore, it is critical to identify mechanisms that mediate heat stroke.
Li Li +9 more
doaj +1 more source
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation [PDF]
, 2020 Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases.
Bertrand, Mathieu +11 more
core +1 more source
Killing AML: RIPK3 leads the way [PDF]
Cell Cycle, 2016 Acute myeloid leukemia (AML) is a heterogeneous group of haematopoietic neoplasms driven partly by the loss of differentiation and the blockade of cell death.
Ulrike, Höckendorf +2 more
openaire +2 more sources
Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]
, 2012 For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Barna, Gabor +6 more
core +9 more sources
eLife, 2021 Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) normally signals to necroptosis by phosphorylating MLKL. We report here that when the cellular RIPK3 chaperone Hsp90/CDC37 level is low, RIPK3 also signals to apoptosis.
Dianrong Li +10 more
doaj +1 more source
Cytoplasmic MYC is an anti-necroptotic protein
Molecular & Cellular Oncology, 2020 Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a ...
Eun-Woo Lee +2 more
doaj +1 more source
Cell Death Discovery, 2022 Neutrophils are important effector cells during inflammation, which play complex roles. Therefore, investigating the regulation of neutrophil accumulation during inflammation might provide targets for treating related diseases.
Wanying Wen +4 more
doaj +1 more source
The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis [PDF]
, 2016 Although necrosis and necroinflammation are central features of many liver diseases, the role of programmed necrosis in the context of inflammation-dependent hepatocellular death remains to be fully determined.
Andreas E. Kremer +24 more
core +1 more source
Sugar Fix Keeps RIPK3 at Bay [PDF]
Immunity, 2019 Immunometabolism is emerging as an important modulator of immune responses. In this issue of Immunity, Li et al. (2019) examine the link between lipopolysaccharide (LPS)-induced glucose metabolism and innate immune signaling and identify how β-N-acetylglucosamine (O-GlcNAc) modification of the RIPK3 RHIM domain limits inflammation and necroptosis.
Cristina, Giogha, Kate E, Lawlor
openaire +2 more sources