Results 31 to 40 of about 11,899 (172)
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
Cell Death and Disease, 2022 Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase RIPK3.
Yanxiang Meng +7 more
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Sugar Fix Keeps RIPK3 at Bay [PDF]
Immunity, 2019 Immunometabolism is emerging as an important modulator of immune responses. In this issue of Immunity, Li et al. (2019) examine the link between lipopolysaccharide (LPS)-induced glucose metabolism and innate immune signaling and identify how β-N-acetylglucosamine (O-GlcNAc) modification of the RIPK3 RHIM domain limits inflammation and necroptosis.
Cristina, Giogha, Kate E, Lawlor
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RIPK3 Slams the Brake on Leukemogenesis [PDF]
Cancer Cell, 2016 Evasion of cell death is a key hallmark of cancers. In this issue of Cancer Cell, Höckendorf and colleagues identified RIPK3, an essential kinase for necroptosis, as having a key role in inhibiting acute myeloid leukemia development.
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Necroptosis, The Double-Edged Sword and Its Therapeutic Implications in Cancer [PDF]
Archives of Pharmaceutical Sciences Ain Shams UniversityNecroptosis is a regulated cell death technique that eliminates cancer cells that are resistant to apoptosis, without requiring caspase. Necroptosis is implicated in several physiological and pathological processes.
Amer, Rana A. +3 more
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RIPK3 Is Largely Dispensable for RIG-I-Like Receptor- and Type I Interferon-Driven Transcriptional Responses to Influenza A Virus in Murine Fibroblasts. [PDF]
PLoS ONE, 2016 The kinase RIPK3 is a key regulator of cell death responses to a growing number of viral and microbial agents. We have found that influenza A virus (IAV)-mediated cell death is largely reliant on RIPK3 and that RIPK3-deficient mice are notably more ...
Shoko Nogusa +4 more
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Viruses, 2022 Receptor interacting protein kinase 3 (RIPK3) is a vital serine/threonine kinase in regulating the programmed destruction of infected cells to defend against RNA viruses.
Guanming Tian +12 more
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Necroptosis induced by RIPK3 requires MLKL but not Drp1 [PDF]
Cell Death & Disease, 2014 Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro-apoptotic Bcl-2 family members Bax or Bak. It has been reported that RIPK3 (receptor interacting protein kinase 3) activates MLKL (mixed lineage kinase domain-like) to cause cell death that requires dynamin-related protein 1 ...
Moujalled, DM +3 more
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RIPK3 Contributes to Lyso-Gb3-Induced Podocyte Death [PDF]
Cells, 2021 Fabry disease is a lysosomal storage disease with an X-linked heritage caused by absent or decreased activity of lysosomal enzymes named alpha-galactosidase A (α-gal A). Among the various manifestations of Fabry disease, Fabry nephropathy significantly affects patients’ morbidity and mortality.
So-Young Kim +10 more
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Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome [PDF]
Journal of Biological Chemistry, 2016 Receptor-interacting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential function in necroptosis. The activity of RIPK3 is controlled by phosphorylation. Once activated, RIPK3 phosphorylates and activates the downstream effector mixed lineage kinase domain-like (MLKL) to induce necroptosis.
Kenta, Moriwaki, Francis Ka-Ming, Chan
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PLoS ONE, 2021 The receptor-interacting protein kinase 3 (RIPK3) is a multi-functional protein best known for facilitating cellular necroptosis and inflammation. Recent evidence from our lab indicates that RIPK3 expression must be tightly regulated in endothelial cells
Siqi Gao +3 more
doaj +1 more source