RIPK3 Contributes to Lyso-Gb3-Induced Podocyte Death [PDF]
Cells, 2021 Fabry disease is a lysosomal storage disease with an X-linked heritage caused by absent or decreased activity of lysosomal enzymes named alpha-galactosidase A (α-gal A). Among the various manifestations of Fabry disease, Fabry nephropathy significantly affects patients’ morbidity and mortality.
So-Young Kim +10 more
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Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency [PDF]
, 2017 Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase activity.
Albert, Matthew L. +26 more
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The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF [PDF]
, 2019 The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner.
Boon, Louis +17 more
core +6 more sources
Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome [PDF]
Journal of Biological Chemistry, 2016 Receptor-interacting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential function in necroptosis. The activity of RIPK3 is controlled by phosphorylation. Once activated, RIPK3 phosphorylates and activates the downstream effector mixed lineage kinase domain-like (MLKL) to induce necroptosis.
Kenta, Moriwaki, Francis Ka-Ming, Chan
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Necroptosis, The Double-Edged Sword and Its Therapeutic Implications in Cancer [PDF]
Archives of Pharmaceutical Sciences Ain Shams UniversityNecroptosis is a regulated cell death technique that eliminates cancer cells that are resistant to apoptosis, without requiring caspase. Necroptosis is implicated in several physiological and pathological processes.
Amer, Rana A. +3 more
doaj +1 more source
Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma. [PDF]
, 2014 Ovarian cancer patients are typically treated with carboplatin and paclitaxel, but suffer a high rate of relapse with recalcitrant disease. This challenge has fostered the development of novel approaches to treatment, including antagonists of the ...
Axelrod, J +10 more
core +2 more sources
Viral RNA at two stages of reovirus infection is required for the induction of necroptosis [PDF]
, 2017 Necroptosis, a regulated form of necrotic cell death, requires the activation of the RIP3 kinase. Here, we identify that infection of host cells with reovirus can result in necroptosis.
Berger, Angela K +6 more
core +2 more sources
Border Security: The Role of RIPK3 in Epithelium Homeostasis [PDF]
Frontiers in Cell and Developmental Biology, 2016 Receptor interacting protein kinase 3 (RIPK3) is a crucial inducer of necroptosis. Its activity is controlled by interaction with other signal adaptors through the "RIP homotypic interaction motif" (RHIM). Recent studies revealed a critical function for RIPK3 in the maintenance of epithelial tissue integrity.
Moriwaki, Kenta +2 more
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Roles of RIPK3 in necroptosis, cell signaling, and disease
Experimental & Molecular Medicine, 2022 AbstractReceptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the “programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is activated by the death receptor ligands and pattern recognition receptors of the innate immune system, and the findings of many reports have suggested that necroptosis is highly
Michael J. Morgan, You-Sun Kim
openaire +2 more sources
RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis.
PLoS Pathogens, 2022 Invasion of the brain by herpes simplex virus 1 (HSV1) can lead to the development of herpes simplex encephalitis (HSE) that is often associated with significant morbidity and mortality regardless of therapeutic intervention.
Hongyan Guo +3 more
doaj +1 more source