Results 71 to 80 of about 17,938 (260)

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation [PDF]

, 2018
In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles of RIPK1 in regulating hematopoiesis and macrophage differentiation, proinflammatory activation, and cell death
Buchrieser, Julian, Cowley, Sally A., Long, Joshua C. D., Long, Joshua C. D., Moore, Michael D., Oliva Martín, María José, Pérez Simón, José Antonio, Venero Recio, José Luis   +7 more
core   +1 more source

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease–Like Autoinflammatory Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease represents a prototypical polygenic systemic autoinflammatory disease, characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still disease remains unreported.
Longfang Chen, Qihua Dai, Yu Xiao, Jialin Dai, Mengyan Wang, Yuning Ma, Yujie Shen, Zhimo Xu, Jianfen Meng, Xia Chen, Da Yi, Yue Sun, Hui Shi, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Tingting Liu, Jialin Teng, Chengde Yang, Jinchao Jia, Qiongyi Hu   +23 more
wiley   +1 more source

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

Nature Communications, 2021
The pseudokinase MLKL is activated by the upstream kinase RIPK3 in the necroptotic pathway but the structural basis of MLKL activation is not well understood yet.
Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D. Cowan, Andre L. Samson, Guillaume Lessene, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy   +14 more
doaj   +1 more source

Akt and mTOR mediate programmed necrosis in neurons [PDF]

, 2014
Necroptosis is a newly described form of regulated necrosis that contributes to neuronal death in experimental models of stroke and brain trauma. Although much work has been done elucidating initiating mechanisms, signaling events governing necroptosis ...
Degterev, A, Golinski, J, Jung, J E, Liang, M, Liu, Q, Lo, E H, Qiu, J, van Leyen, K, Whalen, M J, You, Z   +9 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

RIPK3 modulates sarcoma through immune checkpoint HAVCR2

Oncology Letters, 2022
Sarcomas is a complex group of malignant diseasse with undetermined molecular mechanisms. Receptor interacting serine/threonine kinase 3 (RIPK3) is a necroptosis- and apoptosis-related marker that has been implicated in several immune-associated diseases and aggressive malignant tumours. In the present study, publicly available transcriptome sequencing
Qian, Chen, Wu, Deluo, Du, Jianwei
openaire   +2 more sources

Necroptosis in bacterial infections

Frontiers in Immunology
Necroptosis, a recently discovered form of cell-programmed death that is distinct from apoptosis, has been confirmed to play a significant role in the pathogenesis of bacterial infections in various animal models. Necroptosis is advantageous to the host,
Xing Yu, Jin Yuan, Linxi Shi, Shuying Dai, Lei Yue, Min Yan   +5 more
doaj   +1 more source

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

Interdisciplinary Medicine, EarlyView.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma, Jiahui Huang, Yitong Chen, Haoxuan Wang, Hang Zou, Wanghong Zhao, Zilong Deng   +6 more
wiley   +1 more source

RIPK3 Takes Another Deadly Turn [PDF]

Science, 2014
Blocking an enzyme involved in necroptosis may prove toxic by promoting another form of cell death. [Also see Report by Newton et al. ]
Jianke Zhang, Francis Ka-Ming Chan
openaire   +1 more source

Investigating the role of receptor interacting protein kinase 3 in venous thrombosis

JVS - Vascular Science, 2022
Objective: Venous thromboembolism is a disease that encompasses both deep vein thrombosis and pulmonary embolism. Recent investigations have shown that receptor interacting protein kinase 3 (RIPK3), a protein known for its role in the programmed form of ...
Elise DeRoo, MD, Mitri Khoury, MD, Ting Zhou, PhD, Huan Yang, PhD, Amelia Stranz, BS, MS, Catherine Luke, LVT, LAT, Peter Henke, MD, Bo Liu, PhD   +7 more
doaj   +1 more source