Results 91 to 100 of about 11,899 (172)
RIPK3-Mediated Necroptosis Regulates Cardiac Allograft Rejection
American Journal of Transplantation, 2014 Cell death results in tissue damage and ultimately donor graft rejection and can occur as an active molecular process through apoptotic, necrotic and newly identified receptor interacting protein 1 and 3 kinase (RIPK1/3)-mediated necroptotic pathways. Necroptosis leads to the release of inflammatory molecules which can activate host immune cells.
A, Pavlosky +8 more
openaire +2 more sources
eLifeReceptor interacting protein kinases (RIPK) RIPK1 and RIPK3 play important roles in diverse innate immune pathways. Despite this, some RIPK1/3-associated proteins are absent in specific vertebrate lineages, suggesting that some RIPK1/3 functions are ...
Elizabeth J Fay +4 more
doaj +1 more source
Molecular MetabolismObjective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms that underlie this process are incompletely ...
Noyonika Mukherjee +8 more
doaj +1 more source
Ripk1 and haematopoiesis: a case for LUBAC and Ripk3 [PDF]
Cell Death & Differentiation, 2018 Annibaldi, A, Meier, P
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RIPK3 Contributes to Thyroid Hormone-Induced Photoreceptor Degeneration
International Journal of Molecular SciencesThyroid hormone (TH) regulates cell proliferation, differentiation, and metabolism. Increased TH levels in circulation are associated with a higher incidence of age-related macular degeneration. In mice, TH treatment causes photoreceptor degeneration, which is accompanied by an increase in receptor-interacting serine/threonine-protein kinase 3 (RIPK3 ...
York, Lilliana R. +4 more
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Elevated RIPK3 correlates with disease burden in myelofibrosis
Blood Advances, 2023 Veronika Dill +19 more
openaire +3 more sources
Nature CommunicationsThe essential role of RIPK3 in necroptosis makes its inhibition a promising therapeutic strategy. However, the development of RIPK3 inhibitors has been hampered by on-target apoptosis and limited kinase selectivity.
Haixia Su +11 more
doaj +1 more source
The kinase domain of RIPK3 tunes its scaffolding functions
Cell Death & DifferentiationAbstract The pro-inflammatory programmed cell death pathway, necroptosis, relies on phosphorylation of the terminal effector, MLKL, by RIPK3. RIPK3-deficient mice or those harboring the kinase-inactivating mutation, RIPK3 K51A , are ostensibly normal in the absence of ...
Shene Chiou +16 more
openaire +2 more sources