Results 91 to 100 of about 2,978 (173)

Effects of paraprobiotic Lactobacillus acidophilus LA‐5 on PANoptosis, oxidative stress and inflammation in acetic acid‐induced ulcerative colitis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Ulcerative colitis (UC) is a relapsing inflammatory bowel disease characterised by oxidative stress, inflammation and regulated cell death of the colonic mucosa. Because live probiotics may cause bacteraemia and sepsis in immunocompromised hosts, non‐viable (paraprobiotic) alternatives have attracted interest.
Adem Yavaş, Ezgi Özkıran, Ecem Akan
wiley   +1 more source

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture‐Induced Sepsis and the Ameliorating Effects of Adipose‐Derived Stem Cell Exosomes

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Shao‐Chun Wu, Tsu‐Hsiang Lu, Yi‐Chan Wu, Chia‐Wei Lin, Chia‐Wen Tsai, Ching‐Hua Hsieh   +5 more
wiley   +1 more source

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source

The role of necroptotic extracellular vesicles in NAFLD pathogenesis

, 2022
Tese de mestrado, Ciências Biofarmacêuticas, 2022, Universidade de Lisboa, Faculdade de Farmácia.As vesículas extracelulares (EVs), envolvidas na comunicação intercelular e a necroptose, uma via de necrose regulada, cuja maquinaria facilita o tráfico ...
Campino, Gonçalo Marques de Sousa
core  

Intercellular propagation of RIPK1/RIPK3 amyloid fibrils

Proceedings of the National Academy of Sciences
The canonical necrosome formed by receptor-interacting protein kinase 1 (RIPK1) and RIPK3 is a functional amyloid fibril structure critical to intracellularly drive necroptosis. Since necroptosis leads to the release of intracellular content, the fate of RIPK1/RIPK3 fibrils after necroptotic cell death has not been investigated.
Yeyang Ma, Qiuyuan Zhang, Dekang Li, Kun Zhao, Zefei Li, Yuan Liu, Chu Wang, Bo Sun, Dan Li, Junying Yuan, Cong Liu   +10 more
openaire   +2 more sources

The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis [PDF]

, 2017
Receptor interacting protein kinase 3 (RIPK3) is an essential serine/threonine kinase for necroptosis, a type of regulated necrosis. A variety of stimuli can cause RIPK3 activation through phosphorylation. Activated RIPK3 in turn phosphorylates and activates the downstream necroptosis executioner mixed lineage kinase domain-like (MLKL).
K, Moriwaki, F K-M, Chan
openaire   +2 more sources

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3 [PDF]

, 2014
SummaryReceptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 causes postnatal lethality, which was not prevented by deletion of
Llambi, Fabien, Kelliher, Michelle A., Kanneganti, Thirumala-Devi, Rodriguez, Diego A., Verbist, Katherine C., Janke, Laura J., Gurung, Prajwal, Quarato, Giovanni, Weinlich, Ricardo, Dillon, Christopher P., Gong, Yi-Nan, Green, Douglas R., Brewer, Taylor L., Cripps, James G.   +13 more
core   +1 more source

DataSheet7_Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis.ZIP

, 2021
Background: Depression is a stress-related disorder that seriously threatens people’s physical and mental health. Xiaoyaosan is a classical traditional Chinese medicine formula, which has been used to treat mental depression since ancient times. More and
Xiao-Juan Li (2502517), You-Ming Jiang (395122), Jia-Xu Chen (115580), Zhi-Yi Yan (11727725), Kai-Wen Zhang (2835731), Yue-Yun Liu (395121), Zhe Xue (5811749), Hai-Yan Jiao (11727728), Qing-Yu Ma (10583897), Jian-Bei Chen (11727731), Xi-Hong Wang (2716561)   +10 more
core   +1 more source