Results 111 to 120 of about 2,978 (173)

Prognostic Significance of CHIP and RIPK3 in Non-Small Cell Lung Cancer

, 2020
RIPK3 is a key regulator of necroptosis, which plays a double-edged sword role in tumor progression. CHIP is an E3 ubiquitin ligase that regulates necroptosis by degrading RIPK3.
Joon-Yong Chung, Se Jin Jang, Hyeong Ryul Kim, Joon Seon Song, Chang-Min Choi, Young Soo Park, Jisup Kim   +6 more
core   +1 more source

ORF3 protein of porcine circovirus type 2 induced RIPK3 phosphorylation-driven autophagy to promote viral replication

Scientific Reports
Receptor-interacting protein kinase-3 (RIPK3), a critical regulator of necroptosis and inflammation, has been implicated in modulating viral infections by either promoting host defense or facilitating viral replication.
Zijing Guo, Jingsong Chen, Yuling Li, Yongqiang Lin, Xiongting Huang, Yu Chen, Yanmin Li, Zhidong Zhang   +7 more
doaj   +1 more source

Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

eLife
Receptor interacting protein kinases (RIPK) RIPK1 and RIPK3 play important roles in diverse innate immune pathways. Despite this, some RIPK1/3-associated proteins are absent in specific vertebrate lineages, suggesting that some RIPK1/3 functions are ...
Elizabeth J Fay, Kolya Isterabadi, Charles M Rezanka, Jessica Le, Matthew D Daugherty   +4 more
doaj   +1 more source

TSG From Polygonum multiflorum Thunb. Attenuates Experimental Premature Ovarian Insufficiency in Association With Reduced ZBP1/PANoptosis Signaling

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This study shows that TSG, the major bioactive constituent of Polygonum multiflorum Thunb., ameliorates POI in association with suppression of ZBP1‐driven PANoptosis. In a POI rat model, TSG restored estrous cyclicity, improved hormone profiles, and preserved follicular reserve.
Jinhong Li, Tiao Xie, Chang Lin, Danhong Peng, Qin Shi, Can Zhu   +5 more
wiley   +1 more source

Overexpression and oncogenic role of RIPK3 in acute myeloid leukemia associated with specific subtypes and treatment outcome

BMC Cancer
Background Receptor-interacting protein kinase 3 (RIPK3) has been implicated in the pathogenesis of diverse human cancers. However, the role of RIPK3 in acute myeloid leukemia (AML) is not fully understood, which needs further research and clarification.
Yun Wang, Ting-Juan Zhang, Liu-Chao Zhang, Zi-Jun Xu, Ming-Qiang Chu, Yang-Jing Zhao, Jiang Lin, Jun Qian, Jing-Dong Zhou   +8 more
doaj   +1 more source

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

MedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan, Jinming Zhao, Rong Wang, Yue Shi, Zaozao Chen, Yixuan Ma, Na Li, Wenqing Duan, Duo Lin, Chunxiang Zhang   +9 more
wiley   +1 more source

RIPK3 promotes cell death NLRP3 inflammasome and interleukin-1 activation in the absence of MLKL [PDF]

, 2015
RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of intracellular molecules.
Lawlor, K E, et al
core   +1 more source

The RIPK3-IL-6 axis mediates kidney injury in cytokine storm syndrome

Cell Death and Disease
Receptor-interacting protein kinase 3 (RIPK3) is best known as a mediator of necroptosis, a regulated necrosis pathway observed in diseases with high inflammatory components.
Juan Guerrero-Mauvecin, Diego Martin-Sánchez, Natalia Villar-Gómez, Susana Carrasco, Blanca Chinchilla, Sol Carriazo, Julio M. Martinez-Moreno, Lucia Miño-Izquierdo, Manuel J. Gómez, Maria D. Sanchez-Niño, Alberto Ortiz, Ana B. Sanz   +11 more
doaj   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source