Results 111 to 120 of about 15,294 (209)
eLifeReceptor interacting protein kinases (RIPK) RIPK1 and RIPK3 play important roles in diverse innate immune pathways. Despite this, some RIPK1/3-associated proteins are absent in specific vertebrate lineages, suggesting that some RIPK1/3 functions are ...
Elizabeth J Fay +4 more
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Sepsis: Epidemiology, Pathophysiology, and Management
MedComm, Volume 7, Issue 11, November 2026.Sepsis remains a major global health burden characterized by substantial geographical heterogeneity and a considerable disease burden in China. Its pathophysiology reflects an interconnected network involving excessive inflammation, oxidative stress, immune imbalance and immunoparalysis, mitochondrial damage, endothelial injury, gut dysbiosis ...
Guang‐Tao Pan +8 more
wiley +1 more source
Scientific ReportsReceptor-interacting protein kinase-3 (RIPK3), a critical regulator of necroptosis and inflammation, has been implicated in modulating viral infections by either promoting host defense or facilitating viral replication.
Zijing Guo +7 more
doaj +1 more source
Advanced ScienceReceptor‐interacting protein kinase 3 (RIPK3) is a key player in necroptosis and an emerging inflammation regulator, whose contribution to podocyte injury in diabetic kidney disease (DKD) remain unclear.
Lu'an Li +10 more
doaj +1 more source
BMC CancerBackground Receptor-interacting protein kinase 3 (RIPK3) has been implicated in the pathogenesis of diverse human cancers. However, the role of RIPK3 in acute myeloid leukemia (AML) is not fully understood, which needs further research and clarification.
Yun Wang +8 more
doaj +1 more source
Modest post-transcriptional role for RIPK3 in production of IFN-β upon RLR stimulation.
, 2016 (A)Ripk3+/+ or ripk3-/- MEFs were infected with WT PR8 (m.o.i. = 2), PR8-ΔNS1 (m.o.i. = 1), or transfected with virus mimetic poly(I:C) for the indicated times, and IFN-β in supernatants of cultured cells was quantified by ELISA.
Shoko Nogusa (347948) +4 more
core +1 more source
The RIPK3-IL-6 axis mediates kidney injury in cytokine storm syndrome
Cell Death and DiseaseReceptor-interacting protein kinase 3 (RIPK3) is best known as a mediator of necroptosis, a regulated necrosis pathway observed in diseases with high inflammatory components.
Juan Guerrero-Mauvecin +11 more
doaj +1 more source
Molecular MetabolismObjective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms that underlie this process are incompletely ...
Noyonika Mukherjee +8 more
doaj +1 more source
CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3
, 2016 Receptor-interacting protein kinase 3 (RIPK3) functions as a key regulator of necroptosis. Here, we report that the RIPK3 expression level is negatively regulated by CHIP (carboxyl terminus of Hsp70-interacting protein; also known as STUB1) E3 ligase ...
Jeong, Manhyung +27 more
core +1 more source
Ripk1 and haematopoiesis: a case for LUBAC and Ripk3 [PDF]
Cell Death & Differentiation, 2018 Annibaldi, A, Meier, P
openaire +3 more sources