Results 111 to 120 of about 17,938 (260)
Fig. S3 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis [PDF]
, 2023 Sabira Mohammed +15 more
openalex +1 more source
Clinical Cardiology, Volume 49, Issue 5, May 2026.In this large‐scale UK Biobank analysis, elevated plasma EDA2R was associated with a 74% higher risk of cardiovascular disease and a 177% higher risk of all‐cause mortality, with a 7.2‐year loss in life expectancy in the highest EDA2R group, suggesting its potential as a prognostic biomarker and therapeutic target.
Ziqing Ruan +6 more
wiley +1 more source
Caspase-8 Inactivation in T Cells Increases Necroptosis and Suppresses Autoimmunity in \(Bim^{−/−}\) Mice [PDF]
, 2013 Dysregulation of either the extrinsic or intrinsic apoptotic pathway can lead to various diseases including immune disorders and cancer. In addition to its role in the extrinsic apoptotic pathway, caspase-8 plays nonapoptotic functions and is essential ...
Bohgaki, Miyuki +8 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.Abstract This study established a rat spinal cord injury (SCI) model and an in vitro hypoxic astrocyte model, confirming that hypoxia promotes the formation of the cavity of injury (COI) after SCI by activating the HIF‐1α/JAK/STAT pathway, which in turn induces astrocytic necroptosis and ultimately drives the pathological progression of SCI.
Hangchuan Bi +12 more
wiley +1 more source
Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling [PDF]
, 2016 The kinase RIPK1 is an essential signaling node in various innate immune signaling pathways being most extensively studied in the TNFR1 signaling pathway.
Darding, M, Peltzer, N, Walczak, H
core
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms [PDF]
, 2019 The cytokine TNF promotes inflammation either directly by activating the MAPK and NF-kappa B signaling pathways, or indirectly by triggering cell death.
Bertrand, Mathieu +10 more
core +1 more source
Etiopathogenesis of Immune‐Mediated Necrotizing Myopathy: A Comprehensive Review of Recent Advances
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.This review systematically clarifies that the core of IMNM begins with specific autoantibodies, which in turn trigger complement activation, immune cell infiltration, and a storm of inflammatory factors. Together, these processes induce regulatory cell death and mitochondrial dysfunction, ultimately leading to muscle fiber necrosis. Genetic factors and
Chang Gao +4 more
wiley +1 more source
Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis
Disease Models & Mechanisms, 2020 Receptor-interacting protein kinase 3 (RIPK3) was recently implicated in promoting atherosclerosis progression through a proposed role in macrophage necroptosis.
Sarah Colijn +4 more
doaj +1 more source
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. [PDF]
, 2017 Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Alnemri, Diana +5 more
core +2 more sources
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.Ubc9 expression is downregulated in hepatocytes during hepatic I/R injury. Higher UBC9 expression is associated with improved post‐LT liver function. Ubc9 ameliorates liver damage and inflammation responses in hepatic I/R injury. Ubc9‐mediated Ninj1 SUMOylation at K103 is essential for regulating the subcellular distribution of Ninj1. Ubc9 inhibits the
Kang Huang +8 more
wiley +1 more source