Results 121 to 130 of about 15,294 (209)

RETRACTED ARTICLE: RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brain

, 2017
Oligodendrocyte progenitor cells (OPCs) death is a key contributor to cerebral white matter injury (WMI) in the developing brain. A previous study by our group indicated that receptor-interacting proteins (RIPs) are crucial in mediating necroptosis in ...
Dezhi Mu, Yi Qu, Shiping Li, Q Richard Lu, Jun Tang, Fengyan Zhao, Huiqing Wang, Li Zhang   +7 more
core   +1 more source

Bilirubin directly activates RIPK3 to induce non-classical necroptosis

Cell Discovery
Bilirubin, a byproduct of heme metabolism, is traditionally recognized for its antioxidant properties. However, its accumulation under pathological conditions can result in severe clinical manifestations, including neurotoxicity.
Qian Xue, Xi Ma, Ziyuan Chen, Feifei Ge, Jiawen Wu, Wenhao Bao, Li Zhou, Wei Yi, Min Wu, Siyan Liao, Wenwen Xu, Rongrong He, Jingcheng Feng, Yameng Hu, Xi Chen, Xintian Wu, Ding Yan, Daolin Tang, Xin Chen, Jinbao Liu   +19 more
doaj   +1 more source

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer

, 2018
Necroptosis is a lytic programmed cell death mediated by the RIPK1-RIPK3-MLKL pathway. The loss of Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression and necroptotic potential have been previously reported in several cancer cell ...
Ursula A Matulonis, Patricia Greninger, Junying Yuan, Adnan K. Mookhtiar (5698016), Ursula A. Matulonis (183863), Hoang Son Luu, Ryan J. March (5698019), Cyril H Benes, Ayaz Najafov (322631), Ioannis K Zervantonakis, Regina K. Egan (5540828), Ayaz Najafov, Patricia Greninger (5540831), Regina K Egan, Ryan J March, Cyril H. Benes (408440), Ioannis K. Zervantonakis (116012), Hoang Son Luu (5698022), Junying Yuan (728818), Adnan K Mookhtiar, Daniel G Stover, Daniel G. Stover (5698025)   +21 more
core   +1 more source

RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis

Advanced Science
Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant tissue remodeling and immune dysregulation. While receptor‐interacting protein kinase 3 (RIPK3) is canonically recognized as a central executioner of necroptosis, its non‐necroptotic ...
Tao Yang, Xiao Li, Shuyue Lei, Qingqing Li, Yi Zhang, Zhizhen Hui, Jinjin Ren, Xuelian Yang, Xiaoqian Yang, Chunlan Feng, Yousheng Xu, Dongxin Zhao, Wei Tang   +12 more
doaj   +1 more source

RIPK3 is required for cisplatin-induced necrosis.

, 2014
(A) Effects of RIPK3 knockdown were determined using western blot analysis, β-Actin as a loading control. (B) RIPK3-KD-F2 clones and the parental cells were treated with 10 µM cisplatin for 24 h. Cell viability was assessed by MTT assay.
Zbigniew Cichacz (315940), Yang Xu (178421), Zhengwei Lin (588095), Nan Zhao (351674), Lanping Zhou (588096), Qimin Zhan (331630), Xiaohang Zhao (588097), Lin Zhang (8926), Fang Liu (13271)   +8 more
core   +1 more source

Cationic peroxidase from proso millet induces human colon cancer cell necroptosis by regulating autocrine TNF-α and RIPK3 demethylation

, 2018
Two distinct mechanisms are involved in PmPOD-induced necroptosis, including the autocrine production of TNF-α and the restoration of RIPK3 expression in RIPK3-silenced cells.
Ru Wang, Zhuanhua Wang, Xiaodong Cui
core   +1 more source

RIPK3 Gene [PDF]

, 2020
openaire   +1 more source

The kinase domain of RIPK3 tunes its scaffolding functions

Cell Death & Differentiation
Abstract The pro-inflammatory programmed cell death pathway, necroptosis, relies on phosphorylation of the terminal effector, MLKL, by RIPK3. RIPK3-deficient mice or those harboring the kinase-inactivating mutation, RIPK3 K51A , are ostensibly normal in the absence of ...
Shene Chiou, Christopher R. Horne, Komal M. Patel, Adele Preaudet, James A. Rickard, Samuel N. Young, Asha Jois, Sarah E. Garnish, Anne Hempel, Cathrine Hall, Joanne M. Hildebrand, Andrew J. Kueh, John Silke, Tracy L. Putoczki, Edwin D. Hawkins, Andre L. Samson, James M. Murphy   +16 more
openaire   +2 more sources

Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro

Nature Communications
The essential role of RIPK3 in necroptosis makes its inhibition a promising therapeutic strategy. However, the development of RIPK3 inhibitors has been hampered by on-target apoptosis and limited kinase selectivity.
Haixia Su, Guofeng Chen, Hang Xie, Wanchen Li, Muya Xiong, Jian He, Hangchen Hu, Wenfeng Zhao, Qiang Shao, Minjun Li, Qiang Zhao, Yechun Xu   +11 more
doaj   +1 more source

Elevated RIPK3 correlates with disease burden in myelofibrosis

Blood Advances, 2023
Veronika Dill, Celina V. Wagner, Eva C. Keller, Francisco Jose Fernandez-Hernandez, Khalid Shoumariyeh, Timo O. Odinius, Lars Buschhorn, Richard T. Hauch, Christian Suren, Judith S. Hecker, Peter Herhaus, Michael Sandherr, Burkhard Schmidt, Julia Slotta-Huspenina, Florian Bassermann, Ulrike Höckendorf, Stefanie Jilg, Caterina Branca, Sebastian Vosberg, Philipp J. Jost   +19 more
openaire   +3 more sources