Results 141 to 150 of about 17,938 (260)

RIPK3 Contributes to Thyroid Hormone-Induced Photoreceptor Degeneration

International Journal of Molecular Sciences
Thyroid hormone (TH) regulates cell proliferation, differentiation, and metabolism. Increased TH levels in circulation are associated with a higher incidence of age-related macular degeneration. In mice, TH treatment causes photoreceptor degeneration, which is accompanied by an increase in receptor-interacting serine/threonine-protein kinase 3 (RIPK3 ...
York, Lilliana R., Ma, Hongwei, Le, Yun, Griffin, Courtney T., Ding, Xi-Qin   +4 more
openaire   +2 more sources

The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair [PDF]

, 2014
Kenta Moriwaki, Sakthi Balaji, Thomas J. McQuade, Deepali Malhotra, Joonsoo Kang, Francis K.L. Chan   +5 more
openalex   +1 more source

Mitochondrial permeabilization engages NF-kappa B-dependent anti-tumour activity under caspase deficiency [PDF]

, 2017
Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase activity.
Albert, ML, Blyth, K, Bock, F, Cao, K, Cloix, C, Dhayade, S, Fort, L, Giampazolias, E, Ichim, G, Lecis, D, Lopez, J, Machesky, L, Milling, S, Oberst, A, Orozco, S, Peltzer, N, Proics, E, Ricci, J-E, Roca, A, Rubio-Patino, C, Ryan, KM, Tait, SWG, Taraborrelli, L, Walczak, H, Woodham, E, Yatim, N, Zunino, B   +26 more
core  

Elevated RIPK3 correlates with disease burden in myelofibrosis

Blood Advances, 2023
Veronika Dill, Celina V. Wagner, Eva C. Keller, Francisco Jose Fernandez-Hernandez, Khalid Shoumariyeh, Timo O. Odinius, Lars Buschhorn, Richard T. Hauch, Christian Suren, Judith S. Hecker, Peter Herhaus, Michael Sandherr, Burkhard Schmidt, Julia Slotta-Huspenina, Florian Bassermann, Ulrike Höckendorf, Stefanie Jilg, Caterina Branca, Sebastian Vosberg, Philipp J. Jost   +19 more
openaire   +3 more sources

Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis [PDF]

, 2019
Ting Zhang, Siddharth Balachandran
openalex   +1 more source

Data from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis

, 2023
Sabira Mohammed, Nidheesh Thadathil, Phoebe Ohene-Marfo, Albert L. Tran, Michael Van Der Veldt, Constantin Georgescu, Sangphil Oh, Evan H. Nicklas, Dawei Wang, Nair Hariprasad Haritha, Wenyi Luo, Ralf Janknecht, Benjamin F. Miller, Jonathan D. Wren, Willard M. Freeman, Sathyaseelan S. Deepa   +15 more
openalex   +1 more source

Mechanism of RIPK3 in activation of PRRs/NLRP3 signaling pathway in macrophages induced by wear particles in aseptic joint loosening [PDF]

, 2020
ShiXun Li, Yuan Fu, Changchuan Li, Junxiong Qiu, Manyuan Kuang, Guibin Fang, Sipeng Lin, Yue Ding, Peng Peng   +8 more
openalex   +1 more source

RIPK3 Gene [PDF]

, 2020
openaire   +1 more source

Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro

Nature Communications
The essential role of RIPK3 in necroptosis makes its inhibition a promising therapeutic strategy. However, the development of RIPK3 inhibitors has been hampered by on-target apoptosis and limited kinase selectivity.
Haixia Su, Guofeng Chen, Hang Xie, Wanchen Li, Muya Xiong, Jian He, Hangchen Hu, Wenfeng Zhao, Qiang Shao, Minjun Li, Qiang Zhao, Yechun Xu   +11 more
doaj   +1 more source

Prognostic significance and response to immune checkpoint inhibitors of RIPK3, MLKL and necroptosis in non-small cell lung cancer [PDF]

Nattaya Duangthim, Thanpisit Lomphithak, Ryoko Saito, Yasuhiro Miki, Chihiro Inoue, Ikuro Sato, Eisaku Miyauchi, Jiro Abe, Hironobu Sasano, Siriporn Jitkaew   +9 more
openalex   +1 more source