Results 141 to 150 of about 2,978 (173)

Elevated RIPK3 correlates with disease burden in myelofibrosis

Blood Advances, 2023
Veronika Dill, Celina V. Wagner, Eva C. Keller, Francisco Jose Fernandez-Hernandez, Khalid Shoumariyeh, Timo O. Odinius, Lars Buschhorn, Richard T. Hauch, Christian Suren, Judith S. Hecker, Peter Herhaus, Michael Sandherr, Burkhard Schmidt, Julia Slotta-Huspenina, Florian Bassermann, Ulrike Höckendorf, Stefanie Jilg, Caterina Branca, Sebastian Vosberg, Philipp J. Jost   +19 more
openaire   +3 more sources

RIPK3 wt Allele [PDF]

, 2020
openaire   +1 more source

RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury

, 2018
In patients requiring ventilator support, mechanical ventilation (MV) may induce acute lung injury (ventilator-induced lung injury [VILI]). VILI is associated with substantial morbidity and mortality in mechanically ventilated patients with and without ...
Schenck, Edward J., Jong-Seok, Jones, Daniel S., Fredenburgh, Laura E., Moon, Finkelsztein, Eli J., Ryter, Stefan W., Rebecca M., Kiichi, Siempos, Ilias I., Nakahira, Huh, Jin-Won, Michael Torres, Choi, Augustine M. K., Imamura, Mitsuru, Ma, Kevin C., Lizardi, Baron   +17 more
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RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation [PDF]

Cell, 2017
Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Yueh-Ming Loo, Stephen Tait, Thomas Oguin   +2 more
exaly   +2 more sources

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RIPK1 and RIPK3 in antibacterial defence

Biochemical Society Transactions, 2022
Upon sensing pathogenic bacterial infection, host cells activate a multitude of inflammatory and immunogenic responses to promote bacterial clearance and restore tissue homeostasis. RIPK1 and RIPK3 are two key players in antimicrobial defence, by either driving inflammatory signalling or inducing programmed cell death activation, ranging from apoptosis,
Hui Wen Yeap, Kaiwen W. Chen
openaire   +2 more sources

Regulatory mechanism of CaMKII δ mediated by RIPK3 on myocardial fibrosis and reversal effects of RIPK3 inhibitor GSK'872

Biomedicine and Pharmacotherapy, 2023
Myocardial fibrosis (MF) remains a prominent challenge in heart disease. The role of receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis is evident in the pathogenesis of numerous heart diseases. Concurrently, the activation of Ca2+/calmodulin-dependent protein kinase (CaMKII) is pivotal in cardiovascular disease (CVD).
Xiao-Song Gu, Ji Cao
exaly   +3 more sources

RIPK3 signaling and its role in the pathogenesis of cancers

Cellular and Molecular Life Sciences, 2021
RIPK3 (receptor-interacting protein kinase 3) is a serine/threonine-protein kinase. As a key component of necrosomes, RIPK3 is an essential mediator of inflammatory factors (such as TNFα-tumor necrosis factor α) and infection-induced necroptosis, a programmed necrosis.
Mitchell F Denning, Liu Shanhui, Jiwang Zhang   +2 more
exaly   +3 more sources

The role of RIPK3 in liver mitochondria bioenergetics and function

European Journal of Clinical Investigation, 2021
AbstractBackgroundReceptor‐interacting protein kinase 3 (RIPK3) is a key player of regulated necrosis or necroptosis, an inflammatory form of cell death possibly governing outcomes in chronic liver diseases, such as nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.MethodsThis narrative review is based on literature search using PubMed ...
Tawhidul Islam, Marta B. Afonso, Cecília M. P. Rodrigues   +2 more
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Mechanisms of RIPK3‐induced inflammation

Immunology & Cell Biology, 2017
Receptor‐interacting protein kinase 3 (RIP3/RIPK3) is a multifunctional regulator of cell death and inflammation. It controls signalling downstream of the tumor necrosis factor (TNF) receptor family, DNA‐dependent activator of IFN‐regulatory factors (DAI) and toll‐like receptors (TLRs).
Inbar Shlomovitz, Sefi Zargrian, Motti Gerlic   +2 more
openaire   +2 more sources

Ring closure strategy leads to potent RIPK3 inhibitors

European Journal of Medicinal Chemistry, 2021
Necroptosis is a form of regulated necrotic cell death that is independent of caspases. Receptor-interacting protein kinase 3 (RIPK3) has been identified as a key regulator for necroptosis, and has been proposed as a potential therapeutic target for the treatment of diseases associated with necroptosis. In this report, we describe the design, synthesis,
Shuwei, Wu, Chen, Xu, Kaijiang, Xia, Yu, Lin, Sheng, Tian, Haikuo, Ma, Yuting, Ji, Fang, Zhu, Sudan, He, Xiaohu, Zhang   +9 more
openaire   +2 more sources