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Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs
Trends in Pharmacological Sciences, 2020The scaffolding function of receptor-interacting protein kinase 1 (RIPK1) regulates prosurvival signaling and inflammatory gene expression, while its kinase activity mediates both apoptosis and necroptosis; the latter involving RIPK3 kinase activity.
Martens, Sofie +4 more
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RIPK3 as a potential therapeutic target for Gaucher's disease
Nature Medicine, 2014Gaucher's disease (GD), an inherited metabolic disorder caused by mutations in the glucocerebrosidase gene (GBA), is the most common lysosomal storage disease. Heterozygous mutations in GBA are a major risk factor for Parkinson's disease. GD is divided into three clinical subtypes based on the absence (type 1) or presence (types 2 and 3) of ...
Einat B, Vitner +8 more
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Detection of Necroptosis by Phospho-RIPK3 Immunohistochemical Labeling
2018Activation of the kinase RIPK3 (receptor interacting protein kinase 3) is a hallmark of cells dying by necroptosis. RIPK3 phosphorylates both itself and the pseudokinase MLKL (mixed lineage kinase-like) resulting in MLKL translocation to membranes and cell lysis.
Joshua D, Webster +3 more
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RIPK1 and RIPK3 form mosaic necrosomes
Nature Cell Biology, 2022Weiwei Qi, Junying Yuan
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Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1
EMBO Reports, 2022Mads Gyrd-Hansen +2 more
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Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice
Stem Cell Reports, 2022Mitchell F Denning +2 more
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The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex
Cell, 2018Hao Wu +2 more
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