Results 151 to 160 of about 11,899 (172)

c-Abl activates RIPK3 signaling in Gaucher disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2021
Gaucher disease (GD) is caused by homozygous mutations in the GBA1 gene, which encodes the lysosomal β-glucosidase (GBA) enzyme. GD affects several organs and tissues, including the brain in certain variants of the disease. Heterozygous GBA1 variants are a major genetic risk factor for developing Parkinson's disease.
Yañez Henríquez, María José, Campos, F., Marín Marín, Tamara Alejandra, Klein Posternack, Andrés David, Futerman, A. H., Álvarez, Alejandra R., Zanlungo Matsuhiro, Silvana   +6 more
openaire   +3 more sources

Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs

Trends in Pharmacological Sciences, 2020
The scaffolding function of receptor-interacting protein kinase 1 (RIPK1) regulates prosurvival signaling and inflammatory gene expression, while its kinase activity mediates both apoptosis and necroptosis; the latter involving RIPK3 kinase activity.
Martens, Sofie, Hofmans, Sam, Declercq, Wim, Augustyns, Koen, Vandenabeele, Peter   +4 more
openaire   +3 more sources

RIPK3 as a potential therapeutic target for Gaucher's disease

Nature Medicine, 2014
Gaucher's disease (GD), an inherited metabolic disorder caused by mutations in the glucocerebrosidase gene (GBA), is the most common lysosomal storage disease. Heterozygous mutations in GBA are a major risk factor for Parkinson's disease. GD is divided into three clinical subtypes based on the absence (type 1) or presence (types 2 and 3) of ...
Einat B, Vitner, Ran, Salomon, Tamar, Farfel-Becker, Anna, Meshcheriakova, Mohammad, Ali, Andrés D, Klein, Frances M, Platt, Timothy M, Cox, Anthony H, Futerman   +8 more
openaire   +2 more sources

Detection of Necroptosis by Phospho-RIPK3 Immunohistochemical Labeling

2018
Activation of the kinase RIPK3 (receptor interacting protein kinase 3) is a hallmark of cells dying by necroptosis. RIPK3 phosphorylates both itself and the pseudokinase MLKL (mixed lineage kinase-like) resulting in MLKL translocation to membranes and cell lysis.
Joshua D, Webster, Margaret, Solon, Susan, Haller, Kim, Newton   +3 more
openaire   +2 more sources

RIPK1 and RIPK3 form mosaic necrosomes

Nature Cell Biology, 2022
Weiwei Qi, Junying Yuan
openaire   +2 more sources

A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation

Immunity, 2021
Diana Thomas, Richard Sam, Francis Ka-Ming Chan   +2 more
exaly  

LCK‐Mediated RIPK3 Activation Controls Double‐Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A‐ERK Axis

Advanced Science, 2022
You-Sun Kim, Sung-Min Hwang
exaly  

Regulation of JNK signaling pathway and RIPK3/AIF in necroptosis-mediated global cerebral ischemia/reperfusion injury in rats

Experimental Neurology, 2020
Tingting Huang, Yang Xu, Zhaohu Chu
exaly  

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

Cell, 2018
Hao Wu, MIGUEL Mompean, Günes Bozkurt   +2 more
exaly  

RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation

Cell, 2017
Yueh-Ming Loo, Stephen Tait, Thomas Oguin   +2 more
exaly