Results 131 to 140 of about 17,938 (260)

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. [PDF]

, 2013
A long-standing controversy is whether autophagy is a bona fide cause of mammalian cell death. We used a cell-penetrating autophagy-inducing peptide, Tat-Beclin 1, derived from the autophagy protein Beclin 1, to investigate whether high levels of ...
Clarke, P.G., Ginet, V., Green, D.R., Levine, B., Liu, Y., Posner, B., Puyal, J., Shaw, S.Y., Shoji-Kawata, S., Sumpter, R.M., Tran, K.A., Wei, Y., Xavier, R.J., Zhang, L.   +13 more
core   +1 more source

Persistently Elevated Plasma Concentrations of RIPK3, MLKL, HMGB1, and RIPK1 in Patients with COVID-19 in the Intensive Care Unit

, 2022
Katharina Ruskowski, Holger Neb, Steven R. Talbot, Suma Choorapoikayil, Elisabeth Adam, Andreas von Knethen, Kai Zacharowski, Ulrike Heinicke   +7 more
openalex   +1 more source

RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer [PDF]

, 2018
Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes.Experimental Design: We have investigated the role of RIP1 and the effects of MC2494 in ...
A. Baldi, A. Chambery, A. Mai, A. Nebbioso, A. Pirolli, D. Rotili, D. Tarantino, E. Radaelli, E.P. Spugnini, F. Cuomo, G. Citro, G. Cobellis, H.G. Stunnenberg, J. Shaik, L. Altucci, L. Maravigna, M. Ruvo, M. Zollo, P. Bontempo, P. Ciana, P. De Antonellis, R. Ragno, R. Russo, V. Carafa   +23 more
core   +2 more sources

Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

Advanced Science
Receptor‐interacting protein kinase 3 (RIPK3) is a key player in necroptosis and an emerging inflammation regulator, whose contribution to podocyte injury in diabetic kidney disease (DKD) remain unclear.
Lu'an Li, Jiaying Li, Ruizhao Li, Xingchen Zhao, Yuanhan Chen, Yating Cai, Yan Yang, Weiteng Wang, Siqi Zheng, Li Zhang, Xinling Liang   +10 more
doaj   +1 more source

TET2 amplifies RIPK3/MLKL necroptosis signal by upregulation of PLK3 to promote UVB-induced skin photodamage [PDF]

, 2023
Dan Wang, Shengbo Yang, Yilan Zeng, Ziting Tang, Yuanhong Liu, Xuemei Li, Xiule Zong   +6 more
openalex   +1 more source

Spotted: RIPK3 and MLKL assembling necroptotic complexes

Open Biology
Abstract Necroptosis is a form of regulated cell death (RCD) that evolved as a defence against pathogenic infection. Unlike caspase-dependent RCD, necroptosis, in its canonical form, is driven by receptor-interacting protein kinase 1 and 3 (RIPK1 and RIPK3) signalling, culminating in the activation of the pseudokinase mixed lineage ...
Verónica Martínez-Osorio, Uris Ros, Ana J. García-Sáez   +2 more
openaire   +2 more sources

Cell Death Response to DNA Damage. [PDF]

, 2019
The cell death response to DNA damage is discussed in this Perspectives piece with cancer as the backdrop because DNA damaging agents (DDA) are widely used to treat cancer.
Wang, Jean YJ
core   +1 more source

RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes

Molecular Metabolism
Objective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms that underlie this process are incompletely ...
Noyonika Mukherjee, Christopher J. Contreras, Li Lin, Kaitlyn A. Colglazier, Egan G. Mather, Michael A. Kalwat, Nathalie Esser, Steven E. Kahn, Andrew T. Templin   +8 more
doaj   +1 more source

Nucleic acid sensors and programmed cell death [PDF]

, 2020
Liverpool, Layal, Maelfait, Jonathan, Rehwinkel, Jan   +2 more
core   +2 more sources

Ripk1 and haematopoiesis: a case for LUBAC and Ripk3 [PDF]

Cell Death & Differentiation, 2018
Annibaldi, A, Meier, P
openaire   +3 more sources