Results 131 to 140 of about 2,978 (173)

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer

, 2018
Necroptosis is a lytic programmed cell death mediated by the RIPK1-RIPK3-MLKL pathway. The loss of Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression and necroptotic potential have been previously reported in several cancer cell ...
Ursula A Matulonis, Patricia Greninger, Junying Yuan, Adnan K. Mookhtiar (5698016), Ursula A. Matulonis (183863), Hoang Son Luu, Ryan J. March (5698019), Cyril H Benes, Ayaz Najafov (322631), Ioannis K Zervantonakis, Regina K. Egan (5540828), Ayaz Najafov, Patricia Greninger (5540831), Regina K Egan, Ryan J March, Cyril H. Benes (408440), Ioannis K. Zervantonakis (116012), Hoang Son Luu (5698022), Junying Yuan (728818), Adnan K Mookhtiar, Daniel G Stover, Daniel G. Stover (5698025)   +21 more
core   +1 more source

RIPK3 signaling and effects

RIPK3 is known as a necroptosis inducing cell death protein, but in recent years has been shown to exhibit alternative pathways in the central nervous system.
Ragle, Selma, Snyder, Annelise
core  

Membrane charge primes the necroptotic kinase RIPK3 for amyloid assembly

Receptor-interacting protein kinase 3 (RIPK3) drives necroptosis by assembling into functional amyloid fibrils. Here we show that lipids modulate RIPK3 amyloidogenesis by stabilizing an aggregation-prone intermediate.
Miguel Mompeán, Mompeán, Miguel, Paula Polonio, Reimers, Alexandra, Escobedo-González, Fátima C., Fátima C. Escobedo-González, Gustavo A. Titaux-Delgado, Titaux-Delgado, Gustavo A., Alexandra Reimers, Andrea Gelardo, Polonio, Paula, Gelardo, Andrea   +11 more
core   +1 more source

Bilirubin directly activates RIPK3 to induce non-classical necroptosis

Cell Discovery
Bilirubin, a byproduct of heme metabolism, is traditionally recognized for its antioxidant properties. However, its accumulation under pathological conditions can result in severe clinical manifestations, including neurotoxicity.
Qian Xue, Xi Ma, Ziyuan Chen, Feifei Ge, Jiawen Wu, Wenhao Bao, Li Zhou, Wei Yi, Min Wu, Siyan Liao, Wenwen Xu, Rongrong He, Jingcheng Feng, Yameng Hu, Xi Chen, Xintian Wu, Ding Yan, Daolin Tang, Xin Chen, Jinbao Liu   +19 more
doaj   +1 more source

RIPK3 is required for cisplatin-induced necrosis.

, 2014
(A) Effects of RIPK3 knockdown were determined using western blot analysis, β-Actin as a loading control. (B) RIPK3-KD-F2 clones and the parental cells were treated with 10 µM cisplatin for 24 h. Cell viability was assessed by MTT assay.
Zbigniew Cichacz (315940), Yang Xu (178421), Zhengwei Lin (588095), Nan Zhao (351674), Lanping Zhou (588096), Qimin Zhan (331630), Xiaohang Zhao (588097), Lin Zhang (8926), Fang Liu (13271)   +8 more
core   +1 more source

RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis

Advanced Science
Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant tissue remodeling and immune dysregulation. While receptor‐interacting protein kinase 3 (RIPK3) is canonically recognized as a central executioner of necroptosis, its non‐necroptotic ...
Tao Yang, Xiao Li, Shuyue Lei, Qingqing Li, Yi Zhang, Zhizhen Hui, Jinjin Ren, Xuelian Yang, Xiaoqian Yang, Chunlan Feng, Yousheng Xu, Dongxin Zhao, Wei Tang   +12 more
doaj   +1 more source

Macrophage RIPK3 facilitates TRAF6 K63-linked ubiquitination and exacerbates acute pancreatitis

Acute pancreatitis (AP) is characterized by acinar cell injury and death triggered by multiple etiologies, culminating in local and systemic inflammatory responses. Current therapeutic options for AP, particularly severe AP, remain limited.
Xiaodong Wang, Hailong Jin, Shengchuan Chen, Chaoze Zheng, Kankai Zhu, Jiren Yu, Mingchao Zhang, Jichao Qin, Chunhui Shou, Feng Ma, Xiaosun Liu, Tan Zhang, Liping Yang, Qijun Zhang, Chiyu He, Xingnan Wu   +15 more
core   +1 more source

RIPK3 Gene [PDF]

, 2020
openaire   +1 more source

The kinase domain of RIPK3 tunes its scaffolding functions

Cell Death & Differentiation
Abstract The pro-inflammatory programmed cell death pathway, necroptosis, relies on phosphorylation of the terminal effector, MLKL, by RIPK3. RIPK3-deficient mice or those harboring the kinase-inactivating mutation, RIPK3 K51A , are ostensibly normal in the absence of ...
Shene Chiou, Christopher R. Horne, Komal M. Patel, Adele Preaudet, James A. Rickard, Samuel N. Young, Asha Jois, Sarah E. Garnish, Anne Hempel, Cathrine Hall, Joanne M. Hildebrand, Andrew J. Kueh, John Silke, Tracy L. Putoczki, Edwin D. Hawkins, Andre L. Samson, James M. Murphy   +16 more
openaire   +2 more sources

Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro

Nature Communications
The essential role of RIPK3 in necroptosis makes its inhibition a promising therapeutic strategy. However, the development of RIPK3 inhibitors has been hampered by on-target apoptosis and limited kinase selectivity.
Haixia Su, Guofeng Chen, Hang Xie, Wanchen Li, Muya Xiong, Jian He, Hangchen Hu, Wenfeng Zhao, Qiang Shao, Minjun Li, Qiang Zhao, Yechun Xu   +11 more
doaj   +1 more source