Results 81 to 90 of about 11,899 (172)

RIPK3/Fas-Associated Death Domain Axis Regulates Pulmonary Immunopathology to Cryptococcal Infection Independent of Necroptosis

Frontiers in Immunology, 2017
Fas-associated death domain (FADD) and receptor interacting protein kinase 3 (RIPK3) are multifunctional regulators of cell death and immune response. Using a mouse model of cryptococcal infection, the roles of FADD and RIPK3 in anti-cryptococcal defense
Zhenzong Fa, Zhenzong Fa, Zhenzong Fa, Qun Xie, Qun Xie, Wei Fang, Wei Fang, Haibing Zhang, Haiwei Zhang, Jintao Xu, Weihua Pan, Weihua Pan, Jinhua Xu, Michal A. Olszewski, Michal A. Olszewski, Xiaoming Deng, Wanqing Liao, Wanqing Liao   +17 more
doaj   +1 more source

Leveraging ZBP1 signaling for cancer immunotherapy

Frontiers in Cell Death
Immune checkpoint inhibitors (ICIs) have transformed cancer care, yet durable responses remain limited in a majority of patients. This is particularly true of immunologically cold tumors, which are characterized by insufficient T-cell infiltration, low ...
Parth Desai, Chunxia Wen, Siddharth Balachandran   +2 more
doaj   +1 more source

A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Aging Cell, Volume 25, Issue 7, July 2026.
Aging‐associated MLKL upregulation in hepatocytes induces mitochondrial dysfunction and oxidative stress, accompanied by increased release of pro‐inflammatory extracellular vesicles. These changes are associated with increased p16+/p21+ senescence in hepatocytes and non‐parenchymal cells (macrophages, stellate cells, and endothelial cells), suggesting ...
Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran, Phoebe Ohene‐Marfo, Kara F. Kneuper, Constantin Georgescu, Kamille Pitts, Albert Tran, Zongkai Peng, Amit Singh, Zhibo Yang, Tiangang Li, Bethany Hannafon, Courtney Houchen, Jonathan D. Wren, Andriy Yabluchanskiy, Veronica Galvan, Nagib Ahsan, Michael Kinter, Tommy L. Lewis Jr, Sathyaseelan S. Deepa   +21 more
wiley   +1 more source

Valsartan Reduces Myocardial Ischemia–Reperfusion Injury by Inhibiting Ferritinophagy‐Mediated Ferroptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Revascularisation is the key therapeutic strategy for acute myocardial infarction (AMI). However, the opening of the ‘culprit artery’ is accompanied by myocardial ischemia–reperfusion injury (IRI), partially offsetting the benefits of revascularisation. At present, effective methods to alleviate myocardial IRI are lacking.
Xumin Wang, Bixue Zhang, Xin Li, Qianqian Xu, Yuanliang Sun, Kaikai Zhao, Xintao Zhou, Yuhong Wu, Zheng Cheng   +8 more
wiley   +1 more source

Predominance of Ferroptotic Cell Death Mechanisms in Substantia Nigra Neurodegeneration in Parkinson's Disease

Annals of Neurology, Volume 99, Issue 6, Page 1415-1427, June 2026.
Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng, Anusha Jayaraman, Richard Reynolds, Jia Nee Foo   +3 more
wiley   +1 more source

The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis [PDF]

, 2017
Receptor interacting protein kinase 3 (RIPK3) is an essential serine/threonine kinase for necroptosis, a type of regulated necrosis. A variety of stimuli can cause RIPK3 activation through phosphorylation. Activated RIPK3 in turn phosphorylates and activates the downstream necroptosis executioner mixed lineage kinase domain-like (MLKL).
K, Moriwaki, F K-M, Chan
openaire   +2 more sources

Intercellular propagation of RIPK1/RIPK3 amyloid fibrils

Proceedings of the National Academy of Sciences
The canonical necrosome formed by receptor-interacting protein kinase 1 (RIPK1) and RIPK3 is a functional amyloid fibril structure critical to intracellularly drive necroptosis. Since necroptosis leads to the release of intracellular content, the fate of RIPK1/RIPK3 fibrils after necroptotic cell death has not been investigated.
Yeyang Ma, Qiuyuan Zhang, Dekang Li, Kun Zhao, Zefei Li, Yuan Liu, Chu Wang, Bo Sun, Dan Li, Junying Yuan, Cong Liu   +10 more
openaire   +2 more sources

Overexpression and oncogenic role of RIPK3 in acute myeloid leukemia associated with specific subtypes and treatment outcome

BMC Cancer
Background Receptor-interacting protein kinase 3 (RIPK3) has been implicated in the pathogenesis of diverse human cancers. However, the role of RIPK3 in acute myeloid leukemia (AML) is not fully understood, which needs further research and clarification.
Yun Wang, Ting-Juan Zhang, Liu-Chao Zhang, Zi-Jun Xu, Ming-Qiang Chu, Yang-Jing Zhao, Jiang Lin, Jun Qian, Jing-Dong Zhou   +8 more
doaj   +1 more source

Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

Advanced Science
Receptor‐interacting protein kinase 3 (RIPK3) is a key player in necroptosis and an emerging inflammation regulator, whose contribution to podocyte injury in diabetic kidney disease (DKD) remain unclear.
Lu'an Li, Jiaying Li, Ruizhao Li, Xingchen Zhao, Yuanhan Chen, Yating Cai, Yan Yang, Weiteng Wang, Siqi Zheng, Li Zhang, Xinling Liang   +10 more
doaj   +1 more source

Spotted: RIPK3 and MLKL assembling necroptotic complexes

Open Biology
Abstract Necroptosis is a form of regulated cell death (RCD) that evolved as a defence against pathogenic infection. Unlike caspase-dependent RCD, necroptosis, in its canonical form, is driven by receptor-interacting protein kinase 1 and 3 (RIPK1 and RIPK3) signalling, culminating in the activation of the pseudokinase mixed lineage ...
Verónica Martínez-Osorio, Uris Ros, Ana J. García-Sáez   +2 more
openaire   +3 more sources