Results 81 to 90 of about 2,978 (173)

Role of RIPK3 in IAV-elicited RLR transcriptional responses.

, 2016
(A) qPCR determination of ifnb1 and ifna4 gene expression in mavs+/+ and mavs-/- MEFs demonstrates that transfected poly(I:C) activates antiviral gene expression predominantly via the RLR pathway.
Shoko Nogusa (347948), Siddharth Balachandran (66976), Michael J. Slifker (426947), Justin P. Ingram (3156099), Roshan J. Thapa (403321)   +4 more
core   +1 more source

Kinase domain dimerization drives RIPK3-dependent necroptosis [PDF]

Science Signaling, 2018
Necroptotic cell death is promoted by the dimerization-dependent activation of the kinase RIPK3.
Saravanan Raju, Daniel M. Whalen, Meron Mengistu, Carter Swanson, John G. Quinn, Susan S. Taylor, Joshua D. Webster, Kim Newton, Andrey S. Shaw   +8 more
openaire   +2 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Leveraging ZBP1 signaling for cancer immunotherapy

Frontiers in Cell Death
Immune checkpoint inhibitors (ICIs) have transformed cancer care, yet durable responses remain limited in a majority of patients. This is particularly true of immunologically cold tumors, which are characterized by insufficient T-cell infiltration, low ...
Parth Desai, Chunxia Wen, Siddharth Balachandran   +2 more
doaj   +1 more source

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

Nature Communications, 2021
The pseudokinase MLKL is activated by the upstream kinase RIPK3 in the necroptotic pathway but the structural basis of MLKL activation is not well understood yet.
Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D. Cowan, Andre L. Samson, Guillaume Lessene, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy   +14 more
doaj   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Normal IFN-β signaling in the absence of RIPK3.

, 2016
(A) Heatmap showing expression profiles of genes upregulated by IFN-β in WT MEFs. Expression levels in untreated cells were normalized to one (20, yellow), and genes demonstrating 4-fold or more induction at 6 h were considered induced and sorted based ...
Shoko Nogusa (347948), Siddharth Balachandran (66976), Michael J. Slifker (426947), Justin P. Ingram (3156099), Roshan J. Thapa (403321)   +4 more
core   +1 more source

RIPK3/Fas-Associated Death Domain Axis Regulates Pulmonary Immunopathology to Cryptococcal Infection Independent of Necroptosis

Frontiers in Immunology, 2017
Fas-associated death domain (FADD) and receptor interacting protein kinase 3 (RIPK3) are multifunctional regulators of cell death and immune response. Using a mouse model of cryptococcal infection, the roles of FADD and RIPK3 in anti-cryptococcal defense
Zhenzong Fa, Zhenzong Fa, Zhenzong Fa, Qun Xie, Qun Xie, Wei Fang, Wei Fang, Haibing Zhang, Haiwei Zhang, Jintao Xu, Weihua Pan, Weihua Pan, Jinhua Xu, Michal A. Olszewski, Michal A. Olszewski, Xiaoming Deng, Wanqing Liao, Wanqing Liao   +17 more
doaj   +1 more source

Micro‐ and nanoplastics in gastrointestinal disorders: Mapping the translational gap between exposure, biomonitoring, and pathogenic mechanisms

BMEMat, EarlyView.
This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao, Yujie Luo, Chuanda Zhu, Yanwei Hu   +3 more
wiley   +1 more source

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis [PDF]

Nature Communications, 2016
AbstractCrystals cause injury in numerous disorders, and induce inflammation via the NLRP3 inflammasome, however, it remains unclear how crystals induce cell death. Here we report that crystals of calcium oxalate, monosodium urate, calcium pyrophosphate dihydrate and cystine trigger caspase-independent cell death in five different cell types, which is ...
Mulay, Shrikant R., Desai, Jyaysi, Kumar, Santhosh V., Eberhard, Jonathan N., Thomasova, Dana, ROMOLI, SIMONE, Grigorescu, Melissa, Kulkarni, Onkar P., Popper, Bastian, Vielhauer, Volker, Zuchtriegel, Gabriele, Reichel, Christoph, Bräsen, Jan Hinrich, ROMAGNANI, PAOLA, Bilyy, Rostyslav, Munoz, Luis E., Herrmann, Martin, Liapis, Helen, Krautwald, Stefan, Linkermann, Andreas, ANDERS, HANS JOACHIM   +20 more
openaire   +5 more sources