Results 71 to 80 of about 14,072 (183)
MLKL is a potential prognostic marker in gastric cancer
Oncology Letters, 2019 The mixed lineage kinase domain-like protein (MLKL), which is a major mediator of the necroptosis pathway, is involved in a certain cancers. The present study aimed to explore the expression patterns and exact role of MLKL in gastric cancer (GC) tumorigenesis and progression. In Cancer Cell Line Encyclopedia analysis, the MLKL mRNA expression levels in
Wei, Sun +3 more
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Necroptosis in bacterial infections
Frontiers in ImmunologyNecroptosis, a recently discovered form of cell-programmed death that is distinct from apoptosis, has been confirmed to play a significant role in the pathogenesis of bacterial infections in various animal models. Necroptosis is advantageous to the host,
Xing Yu +5 more
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Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells
Communications Biology, 2023 Non-small cell lung cancer (NSCLC) is the most prevalent type of cancer and the leading cause of cancer-related death. Chemotherapeutic resistance is a major obstacle in treating NSCLC patients.
Huiling Zhou +9 more
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MLKL reveals its friendly face : a role in nerve regeneration
, 2018 In this issue of Molecular Cell, Ying et al. (2018) report on a novel function of MLKL in sciatic nerve regeneration after injury through myelin sheath destabilization.
Vanden Berghe, Tom +3 more
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Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis [PDF]
, 2023 BACKGROUND AND AIMS: Mixed lineage kinase domain-like pseudokinase (MLKL), a key terminal effector of necroptosis, also plays a role in intracellular vesicle trafficking that is critical for regulating liver inflammation and injury in alcohol-associated ...
Jaividhya Dasarathy +33 more
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A novel neurodegenerative spectrum disorder in patients with MLKL deficiency [PDF]
Cell Death & Disease, 2020 Abstract Mixed lineage kinase domain-like (MLKL) is the main executor of necroptosis, an inflammatory form of programmed cell death. Necroptosis is implicated in combating infections, but also in contributing to numerous other clinical conditions, including cardiovascular diseases and neurodegenerative disorders ...
Faergeman, SL +14 more
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Virulence, 2023 Host innate immunity plays a pivotal role in the early detection and neutralization of invading pathogens. Here, we show that pseudokinase mixed lineage kinase-like protein (MLKL) is required for host defence against Streptococcus pluranimalium infection
Yu-Xin Lei +9 more
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MLKL complex in necroptosis assembles and executes function in a dyadic process [PDF]
, 2017 在细胞程序性坏死的过程中，MLKL形成多聚体是非常重要的一步，多聚体也是MLKL执行坏死功能的重要单位。但是MLKL形成多聚的具体机理现在还不是很清楚。本研究表明MLKL多聚体是以八聚体为主要形态，通过MLKL分子间不同的表面氨基酸位点相互作用而形成。我发现MLKL的多聚体主要是八聚体，而八聚体则是由四聚体所组成的。并且MLKL并不会再形成比八聚体更大的多聚体。在体外重组表达的MLKL蛋白进行的层析分离实验中，我发现MLKL只会形成单一的多聚体峰。MLKL从四聚体到八聚体的变化过程中 ...
王梓安
core
Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis [PDF]
, 2018 Necroptotic signaling converges in the assembly of a cytosolic signaling platform, the necrosome, with the activation of its downstream effector, MLKL. RIPK1 and RIPK3, key components of the necrosome, act as signaling intermediates for the activation of
Estornes, Yann +9 more
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Frontiers in PharmacologyThere has been abundant research on the variety of programmed cell death pathways. Apoptosis, pyroptosis, and necroptosis under the action of the caspase family are essential for the innate immune response.
Jun Xiao +3 more
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