Results 91 to 100 of about 12,009 (206)
Acylation of MLKL Impacts Its Function in Necroptosis [PDF]
Mixed lineage kinase domain-like (MLKL) is a key signaling protein of necroptosis. Upon activation by phosphorylation, MLKL translocates to the plasma membrane and induces membrane permeabilization, which contributes to the necroptosis-associated ...
G. Ekin Atilla-Gokcumen (1646659) +5 more
core +1 more source
Cell Proliferation, EarlyView.Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
The composition and formation of MLKL complex in necroptosis [PDF]
, 2015 MLKL的多聚化对于TNF介导的RIP3依赖的细胞坏死非常关键，但是MLKL多聚化的分子机制还不清楚。我们研究发现，MLKL形成的多聚体包含八个MLKL分子，由两个二硫键偶联的四聚体以头对头的形式组成。在四聚体中鼠源MLKL的第169位和275位的半胱氨酸形成分子间的二硫键，但是细胞坏死并不依赖于分子间的二硫键。自磷酸化的RIP3募集MLKL到坏死小体中，在坏死小体中MLKL被RIP3磷酸化，磷酸化的MLKL在坏死小体中形成多聚体 ...
黄德力
core
Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities
Advanced ScienceLytic forms of regulated cell death (RCD) rely on the activation and recruitment of executioner proteins. The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active ...
Lijuan Xu, Chunlin Zhuang
doaj +1 more source
Veterinary Dermatology, EarlyView.Background: Vesicular cutaneous lupus erythematosus (VCLE) is a rare autoimmune disease in dogs and is considered the canine counterpart of human subacute cutaneous lupus erythematosus (SCLE). However, the molecular mechanisms underlying VCLE remain incompletely defined.
Treasa Clifford +5 more
wiley +1 more source
Profiling a killer: MLKL-mediated death and its role in human disease [PDF]
, 2022 © 2022 Sarah Elizabeth GarnishNecroptosis is a lytic and caspase-independent form of programmed cell death. Highly inflammatory in nature, necroptosis results in the permeabilization of biological membranes and the release of inflammatory cytokines ...
Garnish, Sarah Elizabeth
core
Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis. [PDF]
, 2020 Necroptosis is a regulated necrotic cell death pathway involved in development and disease. Its signaling cascade results in the formation of disulfide bond-dependent amyloid-like polymers of mixed lineage kinase domain-like protein (MLKL), which mediate
Johnston, Andrea
core +1 more source
Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury
Experimental Physiology, EarlyView.Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley +1 more source
MLKL is required for PFT induced necroptosis. [PDF]
, 2015 Western blot for pMLKL in MH-S whole cell lysates following their challenge with A)S. marcescens (Sma), ΔshlA, S. pneumoniae (Spn) and Δply and B)S. aureus (Sau), L. monocytogenes (Lmo) and UPEC. C) Immunofluorescence for MLKL (Green) and lipid membrane (
Peter Herman Dube (836751) +8 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar +15 more
wiley +1 more source