Results 91 to 100 of about 14,072 (183)

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science
Lytic forms of regulated cell death (RCD) rely on the activation and recruitment of executioner proteins. The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active ...
Lijuan Xu, Chunlin Zhuang
doaj   +1 more source

NET formation can occur independently of RIPK3 and MLKL signaling [PDF]

, 2016
The importance of neutrophil extracellular traps (NETs) in innate immunity is well established but the molecular mechanisms responsible for their formation are still a matter of scientific dispute.
Kaufmann, Thomas, Wong, Wendy Wei-Lynn, Wicki, Simone, Yousefi, Shida, Poorya Amini, Xiaoliang Wang, Wendy Wei‐Lynn Wong, Stojkov, Darko, Hans‐Uwe Simon, Wang, Xiaoliang, Simon, Hans-Uwe, Darko Stojkov, Amini, Poorya, Shida Yousefi, Simone Wicki, Thomas Kaufmann, Yousefi S, Simon HU, Wong WW, Kaufmann T, Wicki S, Amini P, Wang X, Stojkov D   +23 more
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Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis [PDF]

, 2018
Necroptotic cell death is mediated by the most terminal known effector of the pathway, MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by the upstream kinase, RIPK3, induces unmasking of the N-terminal executioner four-
Wardak, A, Webb, Andrew I., Tanzer, Maria C., James M. Murphy, Lessene, G, Silke, J, Murphy, James M., Andrew I. Webb, Guillaume Lessene, Lucet, I., Isabelle S. Lucet, Peter E. Czabotar, Michael D. W. Griffin, Petrie, EJ, Smith, Brian J., Brian J. Smith, Jacobsen V, A., Young, Samuel N., Dai, W., Griffin, Michael D. W., Smith, BJ, Tanzer, MC, Webb I, A., Wilhelmus J. A. Kersten, Annette V. Jacobsen, Kersten, Wilhelmus J. A., Hildebrand, J., Maria C. Tanzer, Liang, L., Lucet, IS, Sandowl, J., Sandow, JJ, Young, S., Murphy, J., Smith, B., Silke, John, Emma J. Petrie, Griffin, MDW, Angus D. Cowan, Liang, LY, Kersten, W., Jacobsen, Annette V., Hildebrand, JM, Tanzer, M., Silke, J., Sandow, Jarrod J., Lessene, G., Wardak, A., Petrie, Emma J., Czabotar, Peter E., Liang, Lung Yu, Jacobsen, AV, Cowan, AD, Lessene, Guillaume, Webb, AI, Weiwen Dai, Young, SN, Murphy, JM, Kersten, WJA, Cowan, A.D.; id_orcid, Cowan, A., Samuel N. Young, Dai, W, Ahmad Wardak, Lung-Yu Liang, Lucet, Isabelle S., Joanne M. Hildebrand, Hildebrand, Joanne M., Griffin, M., Czabotar, PE, Jarrod J. Sandow, Dai, Weiwen, Wardak, Ahmad, John Silke, Czabotar, P., Petrie, E.   +75 more
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Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Journal of Visualized Experiments, 2018
Necroptosis is a programmed cell death pathway triggered by activation of receptor interacting protein kinase 3 (RIPK3), which phosphorylates and activates the mixed lineage kinase-like domain pseudokinase, MLKL, to rupture or permeabilize the plasma membrane.
Dan E, McNamara, Giovanni, Quarato, Cliff S, Guy, Douglas R, Green, Tudor, Moldoveanu   +4 more
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The Evolution and Biological Activity of Metazoan Mixed Lineage Kinase Domain-Like Protein (MLKL)

In mammals, mixed lineage kinase domain-like protein (MLKL) is the executor of necroptosis. MLKL comprises an N-terminal domain (NTD), which alone suffices to trigger necroptosis by forming pores in the plasma membrane, and a C-terminal domain that ...
Zihao Yuan, Qingyue Wang, Yuan Chen, Li Sun, Hang Xu   +4 more
core   +1 more source

MLKL Modulates Necroptosis and Neuroinflammation in a Mouse Model of MS

Inflammation
MLKL not only plays an important role in necroptosis but also regulates many diseases through non-necrotizing apoptotic function. Many studies have shown that MLKL plays an important role in neuroinflammation, degenerative diseases, and infectious diseases.
Xiao, Minjun, Gao, Ge, Mu, Jingjing, Sun, Qi, Zhao, Yun, Fan, Xueli   +5 more
openaire   +3 more sources

Chemical structure of MLKL binders described in text.

, 2016
Chemical structure of MLKL binders described in text.
Doug Marcotte (2221630), Murugan Paramasivam (3343007), Ben Moree (3210810), Margaret Butko (1740613), Bin Ma (219839), Xin Sun (127355), Laura F. Silvian (2191171), John Howard Jones (3343010), Joshua Salafsky (3210813), Andrea Bertolotti-Ciarlet (380411), Timothy McKee (3343013), Klaus Michelsen (1261590), Ti Wang (238750)   +12 more
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Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL

Necroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation.
Xuan Chen, Fangmin Huang, Yuanyuan Liu, Xingfeng Liu, Jiankun Liang, Fen Hu, Yingying Lin, Lisheng Li, Zeteng Han, Jingyi Li, Yushi Chen, Qiaofa Lin, Jianting Feng, Lanqin Wu   +13 more
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Označevanje aktivne oblike MLKL

, 2020
Nekroptoza je ena izmed oblik programirane nekroze, pri kateri ima ključno vlogo protein MLKL (ang. mixed lineage kinase-domain like), ki ob aktivaciji oligomerizira, se vgradi v plazmalemo in povzroči sprostitev celične vsebine. V signalni poti imajo pomembno vlogo tudi drugi nekroptotični proteini, predvsem kinazi RIPK1 in RIPK3. Nekroptoza nastopi v
openaire   +1 more source

Acylation of MLKL Impacts Its Function in Necroptosis

Mixed lineage kinase domain-like (MLKL) is a key signaling protein of necroptosis. Upon activation by phosphorylation, MLKL translocates to the plasma membrane and induces membrane permeabilization, which contributes to the necroptosis-associated ...
G. Ekin Atilla-Gokcumen (1646659), Viviana Monje-Galvan (1482157), Yasemin Sancak (280592), Shweta Chitkara (17890388), Apoorva J. Pradhan (17890385), Ricardo X. Ramirez (14392134)   +5 more
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