Results 91 to 100 of about 13,017 (220)
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
BMEMat, EarlyView.NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu +13 more
wiley +1 more source
The composition and formation of MLKL complex in necroptosis [PDF]
, 2015 MLKL的多聚化对于TNF介导的RIP3依赖的细胞坏死非常关键，但是MLKL多聚化的分子机制还不清楚。我们研究发现，MLKL形成的多聚体包含八个MLKL分子，由两个二硫键偶联的四聚体以头对头的形式组成。在四聚体中鼠源MLKL的第169位和275位的半胱氨酸形成分子间的二硫键，但是细胞坏死并不依赖于分子间的二硫键。自磷酸化的RIP3募集MLKL到坏死小体中，在坏死小体中MLKL被RIP3磷酸化，磷酸化的MLKL在坏死小体中形成多聚体 ...
黄德力
core
, 2023 Mixed lineage kinase like protein (MLKL) is a key mediator of necroptosis. While previous studies highlighted the important role of MLKL as one of the central regulators of brain damage against acute ischemic neuronal injury, how the activation of MLKL ...
Yi Guo (35817) +8 more
core +1 more source
Targeting MLKL-Driven Necroptosis: A Therapeutic Target in Inflammation and Host Defense
BiomoleculesNecroptosis is a regulated form of programmed cell death that helps the body defend itself against infections and cellular stress, especially when apoptosis is blocked. At the center of this process is mixed lineage kinase domain-like (MLKL) protein, the
Sarmistha Saha +2 more
doaj +1 more source
BMEMat, EarlyView.This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao +3 more
wiley +1 more source
From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems
Chemistry – A European Journal, EarlyView.This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui +5 more
wiley +1 more source
Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities
Advanced ScienceLytic forms of regulated cell death (RCD) rely on the activation and recruitment of executioner proteins. The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active ...
Lijuan Xu, Chunlin Zhuang
doaj +1 more source
Scientific ReportsMixed lineage kinase domain-like protein (MLKL), a critical necroptosis effector, is strongly linked to inflammation, a key component of skin wound healing. However, its precise role in the wound healing process remains inadequately characterized.
Jiamin Zhao +8 more
doaj +1 more source
Profiling a killer: MLKL-mediated death and its role in human disease
, 2022 © 2022 Sarah Elizabeth GarnishNecroptosis is a lytic and caspase-independent form of programmed cell death. Highly inflammatory in nature, necroptosis results in the permeabilization of biological membranes and the release of inflammatory cytokines ...
Garnish, Sarah Elizabeth
core +1 more source