Results 101 to 110 of about 12,009 (206)

MLKL is involved in the regulation of skin wound healing and interplay between macrophages and myofibroblasts in mice

Scientific Reports
Mixed lineage kinase domain-like protein (MLKL), a critical necroptosis effector, is strongly linked to inflammation, a key component of skin wound healing. However, its precise role in the wound healing process remains inadequately characterized.
Jiamin Zhao, Shuangyi Zhang, Yunjie Bai, Zhiguo Gong, Wenhui Bao, Zhuoya Yu, Bo Liu, Wei Mao, Surong Hasi   +8 more
doaj   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, Volume 183, Issue 15, Page 4126-4144, August 2026.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death [PDF]

, 2016
© 2016 Authors. The pseudokinase mixed lineage kinase domain-like (MLKL) is an essential effector of necroptotic cell death. Two distinct human MLKL isoforms have previously been reported, but their capacities to trigger cell death have not been compared
Sweet, MJ, Gunčar, G, Kindlova, M, Bokil, NJ, Murphy, JM, Arnež, KH   +5 more
core   +1 more source

Inactivation of necroptosis-promoting protein MLKL creates a therapeutic vulnerability in colorectal cancer cells

Cell Death and Disease
Mortality from colorectal cancer (CRC) is significant, and novel CRC therapies are needed. A pseudokinase MLKL typically executes necroptotic cell death, and MLKL inactivation protects cells from such death.
Peijia Jiang, Sandhya Chipurupalli, Byong Hoon Yoo, Xiaoyang Liu, Kirill V. Rosen   +4 more
doaj   +1 more source

Luteolin Glycoside From Dracocephalum moldavica L. Attenuates COPD by Modulating TLR4 Expression and Alveolar Cross‐Talk

Food Frontiers, Volume 7, Issue 4, July 2026.
Luteolin‐7‐O‐β‐d‐glucuronide mitigates CS‐induced COPD progression by promoting cytokine‐mediated functional cross‐talk between alveolar macrophages and epithelial cells. ABSTRACT Chronic obstructive pulmonary disease (COPD) is associated with inflammation of the airway and lung parenchyma with limited airflow due to continued exposure to harmful ...
Jianhu Jia, Tiantian Liu, Jiamin Huang, Na Zheng, Wei Wang, Song Wang, Wenjun Wang, Ghulam Jilany Khan, Jianhua Yang, Chenghui He, Fei Li, Hong Duan, Henggui Hu, Kefeng Zhai   +13 more
wiley   +1 more source

Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL [PDF]

Necroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation.
Xuan Chen, Fangmin Huang, Yuanyuan Liu, Xingfeng Liu, Jiankun Liang, Fen Hu, Yingying Lin, Lisheng Li, Zeteng Han, Jingyi Li, Yushi Chen, Qiaofa Lin, Jianting Feng, Lanqin Wu   +13 more
core   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications

MedComm, Volume 7, Issue 7, July 2026.
Pyroptosis maintains immune homeostasis by eliminating damaged or infected cells, but its dysregulation promotes inflammation and cancer progression. The diagram illustrates key activation pathways, links with other programmed cell deaths, and cancer‐specific effects, enhancing its dual protective and pathogenic roles.
Diego Liviu Boaru, Patricia De Castro‐Martinez, Cielo Garcia‐Montero, Oscar Fraile‐Martinez, Majd N. Michael Alhaddadin, Silvestra Barrena‐Blázquez, Laura Lopez‐Gonzalez, Clara Tasende Fernández, Ricardo Alvarado‐Hurtado, Tomás Ratia Giménez, Inmaculada Lasa‐Unzúe, Manuel Díez Alonso, Alberto Gutiérrez‐Calvo, Miguel A. Saez, David Cobo‐Prieto, Jose V. Saz, Melchor Alvarez‐Mon, Raul Diaz‐Pedrero, Miguel A. Ortega   +18 more
wiley   +1 more source

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis [PDF]

, 2018
Necroptotic cell death is mediated by the most terminal known effector of the pathway, MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by the upstream kinase, RIPK3, induces unmasking of the N-terminal executioner four-
Wardak, A, Webb, Andrew I., Tanzer, Maria C., James M. Murphy, Lessene, G, Silke, J, Murphy, James M., Andrew I. Webb, Guillaume Lessene, Lucet, I., Isabelle S. Lucet, Peter E. Czabotar, Michael D. W. Griffin, Petrie, EJ, Smith, Brian J., Brian J. Smith, Jacobsen V, A., Young, Samuel N., Dai, W., Griffin, Michael D. W., Smith, BJ, Tanzer, MC, Webb I, A., Wilhelmus J. A. Kersten, Annette V. Jacobsen, Kersten, Wilhelmus J. A., Hildebrand, J., Maria C. Tanzer, Liang, L., Lucet, IS, Sandowl, J., Sandow, JJ, Young, S., Murphy, J., Smith, B., Silke, John, Emma J. Petrie, Griffin, MDW, Angus D. Cowan, Liang, LY, Kersten, W., Jacobsen, Annette V., Hildebrand, JM, Tanzer, M., Silke, J., Sandow, Jarrod J., Lessene, G., Wardak, A., Petrie, Emma J., Czabotar, Peter E., Liang, Lung Yu, Jacobsen, AV, Cowan, AD, Lessene, Guillaume, Webb, AI, Weiwen Dai, Young, SN, Murphy, JM, Kersten, WJA, Cowan, A.D.; id_orcid, Cowan, A., Samuel N. Young, Dai, W, Ahmad Wardak, Lung-Yu Liang, Lucet, Isabelle S., Joanne M. Hildebrand, Hildebrand, Joanne M., Griffin, M., Czabotar, PE, Jarrod J. Sandow, Dai, Weiwen, Wardak, Ahmad, John Silke, Czabotar, P., Petrie, E.   +75 more
core   +2 more sources

A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Aging Cell, Volume 25, Issue 7, July 2026.
Aging‐associated MLKL upregulation in hepatocytes induces mitochondrial dysfunction and oxidative stress, accompanied by increased release of pro‐inflammatory extracellular vesicles. These changes are associated with increased p16+/p21+ senescence in hepatocytes and non‐parenchymal cells (macrophages, stellate cells, and endothelial cells), suggesting ...
Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran, Phoebe Ohene‐Marfo, Kara F. Kneuper, Constantin Georgescu, Kamille Pitts, Albert Tran, Zongkai Peng, Amit Singh, Zhibo Yang, Tiangang Li, Bethany Hannafon, Courtney Houchen, Jonathan D. Wren, Andriy Yabluchanskiy, Veronica Galvan, Nagib Ahsan, Michael Kinter, Tommy L. Lewis Jr, Sathyaseelan S. Deepa   +21 more
wiley   +1 more source