Results 101 to 110 of about 13,017 (220)

Inactivation of necroptosis-promoting protein MLKL creates a therapeutic vulnerability in colorectal cancer cells

Cell Death and Disease
Mortality from colorectal cancer (CRC) is significant, and novel CRC therapies are needed. A pseudokinase MLKL typically executes necroptotic cell death, and MLKL inactivation protects cells from such death.
Peijia Jiang, Sandhya Chipurupalli, Byong Hoon Yoo, Xiaoyang Liu, Kirill V. Rosen   +4 more
doaj   +1 more source

USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration

Journal of Orthopaedic Translation
Background: Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain. Programmed cell death, particularly necroptosis, contributes to nucleus pulposus (NP) cell loss.
Zhenyu Zhu, Xiaofeng Lin, Fanqi Kong, Ziran Wang, Yongcheng Liang, Chenglong Ji, Hongxuan Chen, Kaiqiang Sun, Changnan Wang, Ximing Xu, Jiangang Shi   +10 more
doaj   +1 more source

Effects of paraprobiotic Lactobacillus acidophilus LA‐5 on PANoptosis, oxidative stress and inflammation in acetic acid‐induced ulcerative colitis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Ulcerative colitis (UC) is a relapsing inflammatory bowel disease characterised by oxidative stress, inflammation and regulated cell death of the colonic mucosa. Because live probiotics may cause bacteraemia and sepsis in immunocompromised hosts, non‐viable (paraprobiotic) alternatives have attracted interest.
Adem Yavaş, Ezgi Özkıran, Ecem Akan
wiley   +1 more source

DataSheet1_The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K.pdf

, 2023
Mixed lineage kinase like protein (MLKL) is a key mediator of necroptosis. While previous studies highlighted the important role of MLKL as one of the central regulators of brain damage against acute ischemic neuronal injury, how the activation of MLKL ...
Yi Guo (35817), Hui-Ling Zhang (13017126), Ali Said (8858204), Rui-Qi Cao (17273776), Xian-Yong Zhou (17273773), Bo Lin (116835), Taous Khan (9379136), Yong-Ming Zhu (1399921), Wei Chen (23863)   +8 more
core   +1 more source

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture‐Induced Sepsis and the Ameliorating Effects of Adipose‐Derived Stem Cell Exosomes

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Shao‐Chun Wu, Tsu‐Hsiang Lu, Yi‐Chan Wu, Chia‐Wei Lin, Chia‐Wen Tsai, Ching‐Hua Hsieh   +5 more
wiley   +1 more source

MLKL reveals its friendly face : a role in nerve regeneration

, 2018
In this issue of Molecular Cell, Ying et al. (2018) report on a novel function of MLKL in sciatic nerve regeneration after injury through myelin sheath destabilization.
Vanden Berghe, Tom, Roelandt, Ria, Vandenabeele, Peter, Declercq, Wim   +3 more
core   +1 more source

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Journal of Visualized Experiments, 2018
Necroptosis is a programmed cell death pathway triggered by activation of receptor interacting protein kinase 3 (RIPK3), which phosphorylates and activates the mixed lineage kinase-like domain pseudokinase, MLKL, to rupture or permeabilize the plasma membrane.
Dan E, McNamara, Giovanni, Quarato, Cliff S, Guy, Douglas R, Green, Tudor, Moldoveanu   +4 more
openaire   +3 more sources

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis [PDF]

, 2018
Necroptotic cell death is mediated by the most terminal known effector of the pathway, MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by the upstream kinase, RIPK3, induces unmasking of the N-terminal executioner four-
Wardak, A, Webb, Andrew I., Tanzer, Maria C., James M. Murphy, Lessene, G, Silke, J, Murphy, James M., Andrew I. Webb, Guillaume Lessene, Lucet, I., Isabelle S. Lucet, Peter E. Czabotar, Michael D. W. Griffin, Petrie, EJ, Smith, Brian J., Brian J. Smith, Jacobsen V, A., Young, Samuel N., Dai, W., Griffin, Michael D. W., Smith, BJ, Tanzer, MC, Webb I, A., Wilhelmus J. A. Kersten, Annette V. Jacobsen, Kersten, Wilhelmus J. A., Hildebrand, J., Maria C. Tanzer, Liang, L., Lucet, IS, Sandowl, J., Sandow, JJ, Young, S., Murphy, J., Smith, B., Silke, John, Emma J. Petrie, Griffin, MDW, Angus D. Cowan, Liang, LY, Kersten, W., Jacobsen, Annette V., Hildebrand, JM, Tanzer, M., Silke, J., Sandow, Jarrod J., Lessene, G., Wardak, A., Petrie, Emma J., Czabotar, Peter E., Liang, Lung Yu, Jacobsen, AV, Cowan, AD, Lessene, Guillaume, Webb, AI, Weiwen Dai, Young, SN, Murphy, JM, Kersten, WJA, Cowan, A.D.; id_orcid, Cowan, A., Samuel N. Young, Dai, W, Ahmad Wardak, Lung-Yu Liang, Lucet, Isabelle S., Joanne M. Hildebrand, Hildebrand, Joanne M., Griffin, M., Czabotar, PE, Jarrod J. Sandow, Dai, Weiwen, Wardak, Ahmad, John Silke, Czabotar, P., Petrie, E.   +75 more
core   +1 more source