Results 101 to 110 of about 6,382 (183)

USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration

Journal of Orthopaedic Translation
Background: Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain. Programmed cell death, particularly necroptosis, contributes to nucleus pulposus (NP) cell loss.
Zhenyu Zhu, Xiaofeng Lin, Fanqi Kong, Ziran Wang, Yongcheng Liang, Chenglong Ji, Hongxuan Chen, Kaiqiang Sun, Changnan Wang, Ximing Xu, Jiangang Shi   +10 more
doaj   +1 more source

ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly [PDF]

, 2015
BACKGROUND: ZFP36 is an mRNA binding protein that exerts anti-tumor activity in glioblastoma by triggering cell death, associated to an increase in the stability of the kinase RIP1. METHODS: We used cell death assays, size exclusion chromatography,
ALECCI, CLAUDIA, Dell' Aquila, Miriam, FERRARI, Sergio, GRANDE, Alexis, Guizzetti, Filippo, MARTELLO, Andrea, MONTORSI, LUCIA, PARENTI, Sandra, Salomoni, Paolo, SELMI, TOMMASO, VOLPI, Nicola, ZANOCCO MARANI, Tommaso   +11 more
core   +1 more source

RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4‐Mediated Mitochondrial Restoration and Inflammation Suppression

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Peripheral nerve injury‐induced muscle atrophy shares core pathophysiological features with systemic wasting disorders including cachexia and sarcopenia, yet early molecular triggers remain undefined. This study investigates the pathogenic role of receptor‐interacting protein kinase 3 (RIPK3) in denervation atrophy.
Yuntian Shen, Chen Zhang, Zihao Zhao, Jia Yi, Xinlei Yao, Bingqian Chen, Hualin Sun   +6 more
wiley   +1 more source

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

Cell Reports, 2014
Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood. Here, we demonstrate that the full four-helical bundle domain (4HBD) in the N-terminal region of MLKL is required and sufficient to induce its oligomerization ...
Dondelinger Yves, Declercq Wim, Montessuit Sylvie, Roelandt Ria, Goncalves Amanda, Bruggeman Inge, Hulpiau Paco, Weber Kathrin, Sehon Clark A, Marquis Robert W, Bertin John, Gough Peter J, Savvides Savvas, Martinou Jean-Claude, Bertrand Mathieu J M, Vandenabeele Peter   +15 more
openaire   +4 more sources

MLKL limits inflammatory responses through negatively regulating Toll-like receptor signaling pathway [PDF]

, 2015
炎症是机体清除有害刺激时做出的保护性反应，同时也是修复受损组织的一个过程。先天性免疫对微生物感染、组织损伤等造成的炎症起到了重要作用。但是，先天性免疫信号必须经过严格的调控，才能避免过于强烈的炎症反应对机体造成的不必要的伤害。Toll样受体在宿主识别病原体的入侵、激活炎症反应的过程中发挥了关键作用，因此，关于Toll样受体信号通路的负调控的研究显得尤为重要。本论文的研究发现，混合系蛋白激酶样结构域蛋白（mixedlineagekinasedomain-likeprotein，MLKL ...
庄秋宇
core  

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties [PDF]

, 2013
Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl transfer, termed pseudokinases, have emerged as important signalling domains across all kingdoms of life.
Babon, Jeffrey J., Bailey, Fiona P., Chen, Kelan, Daly, Roger J., Elowe, Sabine, Eyers, Patrick A., Fukuda, Koichi, Gee, Christine L., Hammaren, Henrik, Jura, Natalia, Liu, Ling, Lucet, Isabelle S., Manning, Gerard, Mudgett, Mary Beth, Murphy, James M., Nimchuk, Zachary, Qin, Jun, Reese, Michael L., Silvennoinen, Olli, Tripaydonis, Anne, Ungureanu, Daniela, Varghese, Leila N., Young, Samuel N., Zhang, Qingwei   +23 more
core   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Distinct Roles of Myeloid‐ and Hepatocyte‐PLA2G6 Deletion in Mice With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Polymorphisms of group VIA calcium‐independent phospholipase A2 (iPLA2β or PLA2G6) are associated with Type‐2 diabetes, blood lipids and inflammation. Global deficiency in iPLA2β‐null mice elicited protection against hepatic steatosis but not hepatic inflammation after high‐fat diet (HFD) feeding.
Gang Li, Simone Staffer, Sabine Tuma‐Kellner, Uta Merle, Walee Chamulitrat   +4 more
wiley   +1 more source

Influence of transplantation of neural stem cells on the expression of genes involved in the programmed cell death following ischemic brain stroke [PDF]

, 2019
Ishemijski moždani udar, te posljedične tkivna hipoksija i ishemija, uzrokuju značajno oštećenje moždanog tkiva. Jedan od pristupa u potrazi za pronalaskom uspješne obnove oštećenog tkiva uključuje primjenu matičnih stanica.
Hribljan, Valentina
core   +1 more source

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source