Results 121 to 130 of about 13,017 (220)

MLKL depletion mediated prolonged TRAIL induced signal through defect of endosomal trafficking

, 2022
Mixed Lineage Kinase Domain-like (MLKL) is the essential molecule of programmed necrotic cell death, Necroptosis. To induce necroptosis, MLKL is phosphorylated by upstream partner, Receptor Interacting Protein Kinase-3 (RIPK3 or RIP3) and then ...
Noh, Hyun Jin, Kim, You Sun, Park, Se Yeon, Park, Han Hee, Ha, Yu Jin, Lee, Eun Ji, Kim, Min Kyoung, Lee, Yu Sang   +7 more
core   +1 more source

Fucoxanthin Attenuates Hepatic Damage in a d‐Galactose‐Induced Accelerated Aging Mouse Model: Insight Into Underlying Mechanisms

Food Frontiers, Volume 7, Issue 5, September 2026.
Fucoxanthin alleviates d‐galactose‐induced hepatic damage by reducing oxidative stress, inflammation, and multiple programmed cell death pathways. ABSTRACT The global population is aging rapidly, and aging‐related hepatic damage poses a significant public health challenge.
Han‐Ni Wei, Cheng‐Yu Yang, Hui Li, Shi‐Xiang Wu, Qing‐Yan Zou, Yan Zheng, Kazuo Miyashita, Yu‐Hong Yang, Lei Du   +8 more
wiley   +1 more source

TSG From Polygonum multiflorum Thunb. Attenuates Experimental Premature Ovarian Insufficiency in Association With Reduced ZBP1/PANoptosis Signaling

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This study shows that TSG, the major bioactive constituent of Polygonum multiflorum Thunb., ameliorates POI in association with suppression of ZBP1‐driven PANoptosis. In a POI rat model, TSG restored estrous cyclicity, improved hormone profiles, and preserved follicular reserve.
Jinhong Li, Tiao Xie, Chang Lin, Danhong Peng, Qin Shi, Can Zhu   +5 more
wiley   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL

Necroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation.
Xuan Chen, Fangmin Huang, Yuanyuan Liu, Xingfeng Liu, Jiankun Liang, Fen Hu, Yingying Lin, Lisheng Li, Zeteng Han, Jingyi Li, Yushi Chen, Qiaofa Lin, Jianting Feng, Lanqin Wu   +13 more
core   +1 more source

MLKL Modulates Necroptosis and Neuroinflammation in a Mouse Model of MS

Inflammation
MLKL not only plays an important role in necroptosis but also regulates many diseases through non-necrotizing apoptotic function. Many studies have shown that MLKL plays an important role in neuroinflammation, degenerative diseases, and infectious diseases.
Xiao, Minjun, Gao, Ge, Mu, Jingjing, Sun, Qi, Zhao, Yun, Fan, Xueli   +5 more
openaire   +3 more sources

Targeted inhibition of MLKL-mediated necroptosis attenuates chronic arsenite exposure-induced lung injury

Ecotoxicology and Environmental Safety
Arsenic, a ubiquitous environmental toxicant, poses a global public health concern through drinking water contamination. While chronic arsenic exposure is epidemiologically associated with respiratory diseases, the molecular mechanisms driving its ...
Yinan Liu, Yonghui Chen, Meng Zhang, Yawen Shi, Yixin Cui, Xinhe Zhang, Lian Li, Xu Zhao, Pinglin Yang, Jinghong Chen   +9 more
doaj   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

MLKL as an emerging machinery for modulating organelle dynamics: regulatory mechanisms, pathophysiological significance, and targeted therapeutics

Frontiers in Pharmacology
Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase featured by a protein kinase-like domain without catalytic activity. MLKL was originally discovered to be phosphorylated by receptor-interacting protein kinase 1/3, typically increase ...
Yang Wang, Wei Wei, Yu Zhang, Jingrong Miao, Xiaofeng Bao, Chunfeng Lu   +5 more
doaj   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source