Results 131 to 140 of about 13,017 (220)

MLKL is required for PFT induced necroptosis.

, 2015
Western blot for pMLKL in MH-S whole cell lysates following their challenge with A)S. marcescens (Sma), ΔshlA, S. pneumoniae (Spn) and Δply and B)S. aureus (Sau), L. monocytogenes (Lmo) and UPEC. C) Immunofluorescence for MLKL (Green) and lipid membrane (
Peter Herman Dube (836751), Kelley Margaret Bradley (836750), Geli Gao (631147), Cecilia Anahí Hinojosa (836749), Ryan Paul Gilley (836748), Norberto González-Juarbe (836747), Molly Ann Bergman (836752), Akinobu Kamei (235460), Carlos Javier Orihuela (836753)   +8 more
core   +1 more source

Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease

MedComm, Volume 7, Issue 9, September 2026.
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi, Dongping Yao, Chanjuan Dong, Xiao Tu, Guojian Liao, Mengfei Long, Yongmei Xie   +6 more
wiley   +1 more source

Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction

Cell Communication and Signaling
Purpose Cardiomyocyte death is a major cytopathologic response in acute myocardial infarction (AMI) and involves complex inflammatory interactions. Although existing reports indicating that mixed lineage kinase domain-like protein (MLKL) is involved in ...
Lijiang Wei, Naifu Wan, Wentong Zhu, Chenchen Liu, Zeyu Chen, Wuwei Rong, Lujun Zhang, Meifeng Xie, Yueqi Qin, Ting Sun, Qing Jing, Ankang Lyu   +11 more
doaj   +1 more source

Transforming Life Science Through Chromosome‐Level Genome Assemblies

Genes to Cells, Volume 31, Issue 5, September 2026.
Chromosome‐level genome assemblies provide a framework for “glocal biology” in species of interest, linking local molecular features to chromosome architecture and evolutionary context. When integrated with pangenome analysis, comparative multi‐omics, genome language models, and experimental approaches, these assemblies enable hypothesis generation and
Tetsuo Kon, Kosuke Kataoka, Yi‐Jyun Luo, Johannes Nicolaus Wibisana, Kouhei Toga, Narumi Uno, Yuki Monden, Mayuko Hamada   +7 more
wiley   +1 more source

Salvianolic Acid B Inhibits Ferroptosis in Acute Lung Injury: Network Analysis and Experimental Validation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT This current study aimed to decipher the anti‐inflammatory, anti‐ferroptosis and pronounced lung‐protective activities of Salvianolic acid B (Sal B) by integrating network pharmacology and experimental confirmation across multiple aspects. The optimal target protein and the relevant molecular mechanisms for Sal B in the context of ALI were ...
Hejun Gao, Renhui Xiong, Na Yue, Jiaxin Wang, Shouyuan Tian   +4 more
wiley   +1 more source

Methamphetamine Exposure Induces Neuronal Programmed Necrosis by Permeabilizing Mitochondria via the RIPK1–RIPK3–MLKL Axis

Toxics
Methamphetamine (Meth), a psychostimulant drug of the amphetamine type, is widely abused and highly neurotoxic. Meth exposure leads to neuronal necroptosis, and the mitochondrial dysfunction may be involved.
Peng Zhou, Jiankang Xuan, Weixiao Xu, Di An, Sining Meng, Hongchao Zhang, Miaoyang Hu, Wanqingyang Hui, Yifei Wang, Jie Cheng, Jianping Xiong, Jun Wang, Xufeng Chen   +12 more
doaj   +1 more source

Označevanje aktivne oblike MLKL

, 2020
Nekroptoza je ena izmed oblik programirane nekroze, pri kateri ima ključno vlogo protein MLKL (ang. mixed lineage kinase-domain like), ki ob aktivaciji oligomerizira, se vgradi v plazmalemo in povzroči sprostitev celične vsebine. V signalni poti imajo pomembno vlogo tudi drugi nekroptotični proteini, predvsem kinazi RIPK1 in RIPK3. Nekroptoza nastopi v
openaire   +1 more source

LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL

Cell Death and Disease
Plasma membrane accumulation of phosphorylated mixed lineage kinase domain-like (MLKL) is a hallmark of necroptosis, leading to membrane rupture and inflammatory cell death.
Nadine Weinelt, Kaja Nicole Wächtershäuser, Gulustan Celik, Birte Jeiler, Isabelle Gollin, Laura Zein, Sonja Smith, Geoffroy Andrieux, Tonmoy Das, Jens Roedig, Leonard Feist, Björn Rotter, Melanie Boerries, Francesco Pampaloni, Sjoerd J. L. van Wijk   +14 more
doaj   +1 more source

The Evolution and Biological Activity of Metazoan Mixed Lineage Kinase Domain-Like Protein (MLKL)

In mammals, mixed lineage kinase domain-like protein (MLKL) is the executor of necroptosis. MLKL comprises an N-terminal domain (NTD), which alone suffices to trigger necroptosis by forming pores in the plasma membrane, and a C-terminal domain that ...
Zihao Yuan, Qingyue Wang, Yuan Chen, Li Sun, Hang Xu   +4 more
core   +1 more source

MLKL wt Allele [PDF]

, 2020
openaire   +1 more source