Results 111 to 120 of about 12,009 (206)
Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.ABSTRACT Revascularisation is the key therapeutic strategy for acute myocardial infarction (AMI). However, the opening of the ‘culprit artery’ is accompanied by myocardial ischemia–reperfusion injury (IRI), partially offsetting the benefits of revascularisation. At present, effective methods to alleviate myocardial IRI are lacking.
Xumin Wang +8 more
wiley +1 more source
Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
Journal of Visualized Experiments, 2018 Necroptosis is a programmed cell death pathway triggered by activation of receptor interacting protein kinase 3 (RIPK3), which phosphorylates and activates the mixed lineage kinase-like domain pseudokinase, MLKL, to rupture or permeabilize the plasma membrane.
Dan E, McNamara +4 more
openaire +3 more sources
MLKL depletion mediated prolonged TRAIL induced signal through defect of endosomal trafficking [PDF]
, 2022 Mixed Lineage Kinase Domain-like (MLKL) is the essential molecule of programmed necrotic cell death, Necroptosis. To induce necroptosis, MLKL is phosphorylated by upstream partner, Receptor Interacting Protein Kinase-3 (RIPK3 or RIP3) and then ...
Noh, Hyun Jin +7 more
core
Spotted: RIPK3 and MLKL assembling necroptotic complexes
Open BiologyAbstract Necroptosis is a form of regulated cell death (RCD) that evolved as a defence against pathogenic infection. Unlike caspase-dependent RCD, necroptosis, in its canonical form, is driven by receptor-interacting protein kinase 1 and 3 (RIPK1 and RIPK3) signalling, culminating in the activation of the pseudokinase mixed lineage ...
Verónica Martínez-Osorio +2 more
openaire +3 more sources
RIPK3 promotes cell death NLRP3 inflammasome and interleukin-1 activation in the absence of MLKL [PDF]
, 2015 RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of intracellular molecules.
Lawlor, K E, et al
core +1 more source
The Evolution and Biological Activity of Metazoan Mixed Lineage Kinase Domain-Like Protein (MLKL) [PDF]
In mammals, mixed lineage kinase domain-like protein (MLKL) is the executor of necroptosis. MLKL comprises an N-terminal domain (NTD), which alone suffices to trigger necroptosis by forming pores in the plasma membrane, and a C-terminal domain that ...
Zihao Yuan +4 more
core +1 more source
Thioredoxin-1 Inhibition Promotes MLKL Activation: Biochemical Insights Into a Suppressor of the Necroptotic Pathway [PDF]
, 2020 Necroptosis is an immunogenic caspase-independent cell death program. While mainly serving to defend against viral infection, dysregulated necroptotic signaling contributes to the pathology of a growing number of human diseases associated with ...
Reynoso, Eduardo
core +1 more source
MSD assay monitoring RIPK3-dependent phosphorylation of the MLKL activation loop. [PDF]
, 2016 (A) GSK872 compound that specifically inhibits RIPK3 inhibits phosphorylation of MLKL as positive control. (B) Crizotinib binding to MLKL does not impact its phosphorylation by RIPK3. (C) Cpd 1 binding to MLKL does not impact its phosphorylation by Ripk3.
Doug Marcotte (2221630) +12 more
core +1 more source
Ecotoxicology and Environmental SafetyArsenic, a ubiquitous environmental toxicant, poses a global public health concern through drinking water contamination. While chronic arsenic exposure is epidemiologically associated with respiratory diseases, the molecular mechanisms driving its ...
Yinan Liu +9 more
doaj +1 more source
MLKL Modulates Necroptosis and Neuroinflammation in a Mouse Model of MS
InflammationMLKL not only plays an important role in necroptosis but also regulates many diseases through non-necrotizing apoptotic function. Many studies have shown that MLKL plays an important role in neuroinflammation, degenerative diseases, and infectious diseases.
Xiao, Minjun +5 more
openaire +3 more sources