Results 111 to 120 of about 13,017 (220)
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu +10 more
wiley +1 more source
Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death [PDF]
, 2016 © 2016 Authors. The pseudokinase mixed lineage kinase domain-like (MLKL) is an essential effector of necroptotic cell death. Two distinct human MLKL isoforms have previously been reported, but their capacities to trigger cell death have not been compared
Sweet, MJ +5 more
core +1 more source
Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury
Experimental Physiology, EarlyView.Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley +1 more source
Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging
Nature CommunicationsHematopoietic stem cells (HSCs) survive many types of cellular stress but often lose their regenerative and lymphopoietic capacities as a result. Such functional decline also occurs with age, and dysfunctional HSCs with impaired mitochondria accumulate ...
Yuta Yamada +13 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar +15 more
wiley +1 more source
Necroptosis: MLKL Polymerization.
, 2018 Necroptosis is a subtype of regulated necrosis that occurs when caspases are inhibited or fail to activate. Stimulus of cell death receptors results in a signaling cascade that triggers caspase independent, immunogenic cell death. The core pathway relies
Johnston, Andrea
core
Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.A GSH‐responsive AIE nanoplatform (TSH NPs) with RGD‐mediated tumor targeting co‐delivers a photosensitizer (TPA) and HCPT for extrahepatic cholangiocarcinoma. The system synergistically enhances PDT and chemotherapy by suppressing HIF‐1α/VEGF‐driven hypoxic adaptation, effectively overcoming PDT resistance.
Yong Qu +19 more
wiley +1 more source
Acylation of MLKL Impacts Its Function in Necroptosis
Mixed lineage kinase domain-like (MLKL) is a key signaling protein of necroptosis. Upon activation by phosphorylation, MLKL translocates to the plasma membrane and induces membrane permeabilization, which contributes to the necroptosis-associated ...
G. Ekin Atilla-Gokcumen (1646659) +5 more
core +1 more source
ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis
, 2016 MLKL is a pore forming pseudokinase involved in the final stage of necroptosis, a form of programmed cell death. Its phosphorylation by RIPK3 is necessary for triggering necroptosis but not for triggering apoptosis, which makes it a unique target for ...
Doug Marcotte (2221630) +12 more
core +1 more source
miR‐15a‐5p Regulates Ferroptosis in Glioblastoma by Targeting GLS2
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Schematic diagram of the mechanism by which miR‐15a‐5p regulates glioblastoma progression through targeting GLS2 and modulating ferroptosis. miR‐15a‐5p regulates the ferroptosis pathway by targeting and inhibiting glutaminase 2 (GLS2) expression: Downregulation of miR‐15a‐5p leads to upregulation of GLS2, which promotes lipid peroxidation, accompanied ...
Yanyan Yu +7 more
wiley +1 more source