Results 151 to 160 of about 6,382 (183)
REGULATED CELL DEATH: APOPTOSIS AND NECROPTOSIS IN U937 CELL LINE [PDF]
, 2014 Dunai Zsuzsanna
core +1 more source
MLKL Role in Necroptosis: a Structural Overview
, 2018 Escura Pérez, Maria +1 more
openaire +1 more source
MLKL forms cation channels [PDF]
Cell Research, 2016 The mixed lineage kinase domain-like (MLKL) protein is a key factor in tumor necrosis factor-induced necroptosis. Recent studies on necroptosis execution revealed a commitment role of MLKL in membrane disruption. However, our knowledge of how MLKL functions on membrane remains very limited.
Hua-yi Wang
exaly +8 more sources
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis [PDF]
Cell Research, 2013 Mixed lineage kinase domain-like protein (Mlkl) was recently found to interact with receptor interacting protein 3 (Rip3) and to be essential for tumor necrosis factor (TNF)-induced programmed necrosis (necroptosis) in cultured cell lines. We have generated Mlkl-deficient mice by transcription activator-like effector nucleases (TALENs)-mediated gene ...
Jianfeng Wu, Zhe Huang, Zhirong Zhang
exaly +4 more sources
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis [PDF]
EMBO Journal, 2021 AbstractMixed lineage kinase domain‐like (MLKL) is the executioner in the caspase‐independent form of programmed cell death called necroptosis. Receptor‐interacting serine/threonine protein kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomerization, membrane translocation and membrane disruption.
Zikou Liu +2 more
exaly +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
PROTACs Targeting MLKL Protect Cells from Necroptosis
Journal of Medicinal Chemistry, 2023Mixed Lineage Kinase domain-Like pseudokinase (MLKL) is implicated in a broad range of diseases due to its role as the ultimate effector of necroptosis and has therefore emerged as an attractive drug target. Here, we describe the development of PROteolysis TArgeting Chimeras (PROTACs) as a novel approach to knock down MLKL through chemical means.
Oliver H. Rathje +3 more
openaire +2 more sources
Necrosome core machinery: MLKL
Cellular and Molecular Life Sciences, 2016In the study of regulated cell death, the rapidly expanding field of regulated necrosis, in particular necroptosis, has been drawing much attention. The signaling of necroptosis represents a sophisticated form of a death pathway. Anti-caspase mechanisms (e.g., using inhibitors of caspases, or genetic ablation of caspase-8) switch cell fate from ...
Jing, Zhang +3 more
openaire +2 more sources
MLKL in cancer: more than a necroptosis regulator
Cell Death & Differentiation, 2021Mixed lineage kinase domain-like protein (MLKL) emerged as executioner of necroptosis, a RIPK3-dependent form of regulated necrosis. Cell death evasion is one of the hallmarks of cancer. Besides apoptosis, some cancers suppress necroptosis-associated mechanisms by for example epigenetic silencing of RIPK3 expression.
Sofie Martens +4 more
openaire +2 more sources
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis [PDF]
Molecular Cell, 2018 Necroptosis is an important form of lytic cell death triggered by injury and infection, but whether mixed lineage kinase domain-like (MLKL) is sufficient to execute this pathway is unknown. In a genetic selection for human cell mutants defective for MLKL-dependent necroptosis, we identified mutations in IPMK and ITPK1, which encode inositol phosphate ...
Dan E Mcnamara +2 more
exaly +3 more sources
TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL [PDF]
Molecular Cell, 2019 Necroptosis, a cell death pathway mediated by the RIPK1-RIPK3-MLKL signaling cascade downstream of tumor necrosis factor α (TNF-α), has been implicated in many inflammatory diseases. Members of the TAM (Tyro3, Axl, and Mer) family of receptor tyrosine kinases are known for their anti-apoptotic, oncogenic, and anti-inflammatory roles.
Ayaz Najafov +2 more
exaly +3 more sources