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A patent review of MLKL modulators (2023 – present)
Expert Opinion on Therapeutic PatentsMixed-spectrum kinase structural domain-like protein (MLKL), which emerged as a pivotal regulator in biomedical research, plays a critical role in necroptotic pathways. Recent advancements have underscored the therapeutic potential of MLKL modulators.This review focuses on the patent literature covering MLKL-targeted molecules published from 2023 to ...
Bo-Wen Wan +2 more
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Insane in the membrane: a structural perspective of MLKL function in necroptosis
Immunology & Cell Biology, 2017Necroptosis (or ‘programmed necrosis’) is a caspase‐independent cell death pathway that operates downstream of death receptors, including Tumour Necrosis Factor Receptor‐1 (TNFR1), and the Toll‐like receptors, TLR3 and TLR4. Owing to its immunogenicity, necroptosis has been attributed roles in the pathogenesis of several diseases, including ...
Emma J, Petrie +2 more
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Necroptosis: MLKL Polymerization.
Journal of nature and scienceNecroptosis is a subtype of regulated necrosis that occurs when caspases are inhibited or fail to activate. Stimulus of cell death receptors results in a signaling cascade that triggers caspase independent, immunogenic cell death. The core pathway relies on receptor interacting protein kinase (RIPK) 1 and 3, which interact through their receptor ...
Andrea, Johnston, Zhigao, Wang
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Advances in MLKL-targeted inhibitors and PROTACs for necroptosis therapeutics
Bioorganic & Medicinal ChemistryNecroptosis is a highly regulated form of cell death. Mixed lineage kinase domain-like protein (MLKL) serves as its central effector and plays a critical role in various physiological and pathological processes. Given its close association with multiple diseases, MLKL has emerged as a promising therapeutic target. This review highlights recent advances
Pengcheng, Dai +4 more
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Investigating MLKL Regulation in Necroptosis
Necroptosis is a form of regulated necrosis mediated by the mixed lineage kinase domain-like (MLKL), which naturally exists in alternative spliced isoforms. Through alternative splicing, a short amino acid microexon is inserted into the C-terminal α-helix (Hc) of MLKL, generating a necroptosis-deficient isoform that blocks the cell-killing activity of ...openaire +1 more source
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
Cell, 2017Andreas Linkermann +2 more
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MLKL Forms Disulfide Bond-Dependent Amyloid-Like Polymers to Induce Necroptosis
Proceedings of the National Academy of Sciences of the United States of America, 2017Zhigao Wang +2 more
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